Fig. 1

Expression of N6-methyladenosine (m6A) and methyltransferase-like 3 (METTL3) in different endometrial samples. m6A and METTL3 levels were downregulated in the mid-secretory endometria of normal fertile women (the NS group) without endometriosis, whereas it was upregulated during the same phase in the endometria of women with endometriosis-related infertility (the ES group). a m6A levels in the endometria of normal fertile women in the proliferative phase (the NP group) (n = 21) and the NS group (n = 21). b mRNA levels of m6A-associated genes in the tissues detected by qRT-PCR. c Protein levels of METTL3 in sampled tissues detected by western blot analysis. d Protein levels of METTL3 in sampled tissues detected by immunohistochemical (IHC) staining (scale bar = 100 μm or scale bar = 50 μm). e m6A levels in the NS (n = 14) and ES (n = 14) groups. f Protein levels of METTL3 in sampled tissues detected by western blot analysis. g Protein levels of METTL3 in sampled tissues detected by IHC staining (scale bar = 100 μm or scale bar = 50 μm). All experiments were repeated in triplicate or quadruplicate. The blots in this figure are cropped (please refer to supplementary files for details). Data with error bars are presented to indicate the mean ± standard error of the mean (SEM) values. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001