Fig. 7
From: Decreased HAT1 expression in granulosa cells disturbs oocyte meiosis during mouse ovarian aging
Schematic of the downregulated HAT1 in GCs dominating oocyte meiotic defects and aneuploidy. Under normal circumstances, HAT1 in GCs maintains the normal meiosis process of oocytes by acetylating FoxO1 to regulate AREG expression. HAT1 declines in GCs with maternal age, which causes decreased AREG expression via downregulation of acetylated FoxO1, further disrupting oocyte meiotic progression and causing aneuploidy