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Table 5 The impact of embryo biopsy on health outcomes at 2 years

From: Cleavage-stage or blastocyst-stage embryo biopsy has no impact on growth and health in children up to 2 years of age

 

EBD5 FET

N=57

EBD3 FET

N=128

EBD3 FRESH

N=140

Non-biopsy FET

N=150

Non-biopsy FRESH

N=131

Developmental disorder

 Mild

4 (7.0)

6 (4.7)

5 (3.6)

9 (6)

5 (3.8)

 Severe

1 (1.7)

2 (1.6)

2 (1.4)

4 (2.6)

3 (2.3)

Hospital admission

 At least once

17 (29.8)

31 (24.2)

35 (25.0)

40 (26.6)

31 (23.6)

Chronic medication use

 Yes

6 (10.5)

14 (10.9)

13 (9.3)

17 (11.3)

14 (10.7)

Surgical intervention

 Yes

5 (8.8)*

20 (15.6)

18 (12.8)

32 (21.3)

18 (13.7)

 For congenital malformation

1

6

5

5

3

 Other reason

4

14

13

27

15

  1. EBD5 Embryo Biopsy Day 5, EBD3 Embryo Biopsy Day 3, FRESH fresh embryo transfer, FET frozen-thawed embryo transfer
  2. *P<0.05 for comparison between EBD5 FET vs Non-Biopsy FET; all other comparisons were not significantly different