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Table 4 The impact of embryo biopsy on anthropometrics from birth up to 2 years in fresh cycles

From: Cleavage-stage or blastocyst-stage embryo biopsy has no impact on growth and health in children up to 2 years of age

 

EBD3 FRESH

Non-biopsy FRESH

EBD3 FRESH vs Non-biopsy FRESH

   

Unadjusted mean difference (95% CI)

Adjusteda mean difference (95% CI)

At birth

N=308

N=781

  

 Weight (g)

3304 (557)

3226 (539)

78 [5.58,149.6]

49 [-29.8,128.3]

 Weight SDS

-0.15 (1.1)

-0.29 (1.0)

0.14 [0.002,0.28]

0.06 [0.092,0.21]

 Length (cm)

49.8 (2.7)

49.6 (2.6)

0.24 [-0.11,0.60]

0.19 [-0.20,0.58]

 Length SDS

-0.21 (1.2)

-0.32 (1.5)

0.11 [-0.05,0.28]

0.09 [-0.10,0.27]

 Head circumference (cm)

34.3 (1.7)

34.1 (1.9)

0.20 [-0.09,0.49]

0.15 [-0.18,0.47]

 Head circumference SDS

-0.24 (1.2)

-0.39 (1.5)

0.14 [-0.08,0.36]

0.09 [-0.15,0.34]

At infancy

N=215

N=282

  

 Age (years)

0.4 (0.4)

0.4 (0.2)

  

 Weight SDS

0.0 (1.1)

-0.03 (1.1)

0.03 [-0.17,0.23]

0.07 [-0.15,0.29]

 Height SDS

0.03 (1.2)

-0.07 (1.2)

0.10 [-0.11,0.31]

0.09 [-0.14,0.32]

 Head circumference SDS

0.02 (1.0)

0.02 (1.1)

0.00 [-0.18,0.18]

-0.01 [-0.21,0.20]

At early childhood

N=140

N=131

  

 Age (years)

2.1 (0.4)

2.2 (0.4)

  

 Weight SDS

-0.19 (1.2)

-0.20 (1.2)

0.01 [-0.27,0.29]

0.09 [-0.23,0.40]

 Height SDS

-0.22 (1.2)

-0.18 (1.2)

-0.03 [-0.31,0.25]

-0.02 [-0.34,0.29]

 Head circumference SDS

0.08 (1.0)

0.03 (0.9)

0.06 [-0.17,0.29]

0.05 [-0.21,0.31]

 Waist circumference SDS

0.69 (1.2)

0.61 (1.1)

0.08 [-0.24,0.39]

-0.14[-0.22,0.50]

 Mid-upper arm circumference SDS

0.04 (1.0)

0.36 (2.0)

-0.31 [-0.74,0.12]

-0.18 [-0.66,0.30]

Growth

 ∆ weight SDS birth to infancy

0.22 (1.2)

0.42 (1.1)

-0.20 [-0.41,0.01]

-0.13 [-0.36,0.10]

 ∆ height SDS birth to infancy

-0.16 (0.8)

-0.09 (0.8)

-0.02 [-0.19,0.16]

-0.03 [-0.22,0.17]

 ∆ weight SDS infancy to early childhood

0.25 (1.1)

0.26 (0.9)

-0.07 [-0.27,0.13]

-0.03 [-0.25,0.19]

 ∆ height SDS infancy to early childhood

-0.27 (1.0)

-0.07 (0.9)

-0.20 [-0.44,0.03]

-0.19 [-0.45,0.07]

  1. EBD3 Embryo Biopsy Day 3, FRESH fresh embryo transfer,
  2. aadjusted for treatment (number of oocytes at pick-up) and maternal characteristics (nulliparity, age, BMI, smoking, alcohol, pregnancy-induced hypertensive disorder, gestational diabetes)