Table 1 Treatment and maternal characteristics of the biopsy and non-biopsy groups
EBD5 FET N= 222 | EBD3 FET N=322 | EBD3 FRESH N=308 | Non-biopsy FET N=751 | Non-biopsy FRESH N=781 | |
|---|---|---|---|---|---|
Treatment characteristics | |||||
Number oocytes at retrieval (n, %) | |||||
<4 | 7 (3.2) | 3 (0.9) | 10 (3.2) | 3 (0.4) | 20 (2.6) |
4-18 | 162 (73.0) | 191 (59.3) | 254 (82.5) | 469 (62.5) | 679 (86.9) |
>18 | 53 (23.9) | 128 (39.8) | 44 (14.3) | 279 (37.2) | 82 (10.5) |
Supernumerary embryo(s) for vitrification | |||||
Yes | 182 (59) | 654 (84) | |||
No | 126 (41) | 127 (16) | |||
Type of sperm (n, %) | |||||
Ejaculated sperm | 217 (97.7) | 316 (98.1) | 301 (97.7) | 709 (94.4) | 726 (93.0) |
Non-ejaculated sperm | 5 (2.3) | 6 (1.9) | 7 (2.3) | 42 (5.6) | 55 (7.0) |
Origin of sperm (n, %) | |||||
Partner sperm | 220 (99.1) | 314 (97.5) | 303 (98.4) | 644 (85.8) | 674 (86.3) |
Donor sperm | 2 (0.9) | 8 (2.5) | 5 (1.6) | 107 (14.2) | 107 (13.7) |
Indication for embryo biopsy (n, %) | |||||
Genetic with infertility | 53 (23.9) | 18 (5.6) | 35 (11.4) | ||
Genetic without infertility | 133 (59.9) | 302 (93.8) | 267 (86.7) | ||
Non-genetic with infertility | 36 (16.2) | 2 (0.6) | 6 (1.9) | ||
Indication for ICSI (n, %) | |||||
Male factor | 286 (38.1) | 299 (38.3) | |||
Female factor | 160 (21.3) | 142 (18.2) | |||
Combined male + female factor | 79 (10.5) | 63 (8.1) | |||
Idiopathic | 226 (30.1) | 277 (35.4) | |||
Cycle protocol (n, %) | |||||
Hormonal replacement therapy | 109 (49.1) | 158 (49.0) | 0 | 279 (37.1) | 0 |
(Modified) Natural cycle | 106 (47.6) | 154 (47.9) | 0 | 458 (61.0) | 5 (0.6) |
Stimulated cycle | 7 (3.1) | 10 (3.1) | 308 (100) | 14 (1.9) | 776 (99.4) |
Cycle strategy (n, %) | |||||
Freeze-all | 222 (100) | 228 (70.8) | 396 (52.7) | ||
Previous embryo transfer | 0 (0) | 94 (29.2 | 355 (47.3) | ||
Maternal characteristics | |||||
Maternal age at delivery, years (mean, SD) | 34.2 (4.7) | 31.7 (3.6) | 31.8 (3.5) | 32.9 (3.9) | 31.8 (3.9) |
Maternal BMI, kg/m2 (mean, SD) | 23.5 (3.6) | 23.9 (4.4) | 24.3 (4.4) | 23.5 (4.5) | 23.8 (4.3) |
Pregnancy-induced hypertensive disorder (n, %) | 15 (6.8) | 27 (8.4) | 19 (6.2) | 69 (9.2) | 50 (6.4) |
Gestational diabetes (n, %) | 18 (8.1) | 14 (4.3) | 22 (7.1) | 63 (8.4) | 62 (7.9) |
N=197 | N=274 | N=252 | N=698 | N=674 | |
Nulliparous (n, %) | 126 (63.9) | 160 (58.4) | 160 (63.5) | 222 (31.9) | 156 (23.1) |
N=198 | N=298 | N=280 | N=613 | N=631 | |
Maternal smoking (n, %) | 1 (0.5) | 6 (2.0) | 7 (2.5) | 21 (3.4) | 27 (4.2) |
N=202 | N=299 | N=281 | N=660 | N=679 | |
Maternal alcohol consumption (n, %) | 9 (4.4) | 20 (6.7) | 20 (7.1) | 44 (6.6) | 52 (7.6) |