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Table 2 Metabolic parameters in ART and control groups during different pregnant periods

From: Longitudinal changes of oxidative stress and PON1 lactonase activity and status in older pregnant women undergoing assisted reproductive technology: a prospective nested case-control study

 

1st trimester

2nd trimester

3rd trimester

delivery

P

Control (n = 129)

     

FGlu (mmol/L)

4.40 ± 0.25

4.34 ± 0.19

4.31 ± 0.21a

4.34 ± 0.32

0.038

FIns (pmol/L)

7.24 ± 5.07

10.55 ± 10.47a

11.52 ± 9.37a

8.67 ± 5.16c

< 0.001

HOMA-IR

1.42 ± 1.01

2.04 ± 2.08a

2.22 ± 1.90a

1.69 ± 0.99c

< 0.001

TG (mmol/L)

1.57 ± 0.47

2.65 ± 0.88a

3.39 ± 1.19a, b

3.66 ± 1.47a, b, c

< 0.001

TC (mmol/L)

4.44 ± 0.56

5.64 ± 0.81a

5.96 ± 0.86a, b

5.85 ± 1.10a, b

< 0.001

HDL-C (mmol/L)

1.77 ± 0.33

2.06 ± 0.42a

1.99 ± 0.39a, b

1.82 ± 0.39b, c

< 0.001

LDL-C (mmol/L)

2.22 ± 0.58

3.06 ± 0.83a

3.33 ± 0.94a, b

3.18 ± 1.00a

< 0.001

AI

1.59 ± 0.52

1.81 ± 0.52a

2.07 ± 0.56a, b

2.28 ± 0.59a, b, c

< 0.001

Apo A1 (g/L)

2.13 ± 0.34

2.53 ± 0.52a

2.45 ± 0.41a

2.35 ± 0.51a. b

< 0.001

ApoB (g/L)

0.74 ± 0.16

0.99 ± 0.20a

1.11 ± 0.21a, b

1.12 ± 0.27a, b

< 0.001

ApoB/apoA1

0.36 ± 0.11

0.41 ± 0.12a

0.47 ± 0.13a, b

0.49 ± 0.14a, b, c

< 0.001

ART (n = 64)

     

FGlu (mmol/L)

4.39 ± 0.21

4.33 ± 0.18

4.34 ± 0.20

4.56 ± 0.34*, a, b, c

< 0.001

FIns (pmol/L)

7.13 ± 3.49

8.94 ± 4.65a

10.88 ± 5.32a, b

11.85 ± 10.89*, a, b

< 0.001

HOMA-IR

1.39 ± 0.68

1.72 ± 0.88a

2.09 ± 1.02a, b

2.40 ± 2.20*, a, b

< 0.001

TG (mmol/L)

1.72 ± 0.57*

2.77 ± 0.94a

3.64 ± 1.34a, b

4.34 ± 2.05*, a, b, c

< 0.001

TC (mmol/L)

4.66 ± 0.63*

5.85 ± 0.86a

6.12 ± 0.94a

6.16 ± 1.15a

< 0.001

HDL-C (mmol/L)

1.73 ± 0.35

2.06 ± 0.43a

1.96 ± 0.39a, b

1.83 ± 0.37b, c

< 0.001

LDL-C (mmol/L)

2.45 ± 0.68*

3.30 ± 0.80a

3.50 ± 0.94a

3.30 ± 0.96a

< 0.001

AI

1.79 ± 0.63*

1.93 ± 0.55

2.20 ± 0.60a, b

2.42 ± 0.66a, b, c

< 0.001

Apo A1 (g/L)

2.10 ± 0.37

2.55 ± 0.49a

2.46 ± 0.49a

2.30 ± 0.44a, b

< 0.001

ApoB (g/L)

0.79 ± 0.17*

1.03 ± 0.21a

1.14 ± 0.26a, b

1.17 ± 0.30a, b

< 0.001

ApoB/apoA1

0.39 ± 0.12*

0.42 ± 0.12a

0.49 ± 0.16a, b

0.53 ± 0.16a, b

< 0.001

  1. Values are presented as the mean ± SD
  2. Abbreviations: AI atherosclerosis index, ApoA1 apolipoprotein A1, ApoB apolipoprotein B, ART artificial reproductive technology, FGlu fasting glucose, FIns fasting insulin, HDL-C high-density lipoprotein cholesterol, HOMA-IR homeostasis model assessment of insulin resistance, LDL-C low-density lipoprotein cholesterol, TC total cholesterol, TG triglycerides
  3. All comparisons of parameters were corrected for differences in age and pre-pregnancy BMI between the ART and control groups
  4. *P < 0.05, compared with the control corresponding subgroup; aP < 0.05, compared with 1st trimester subgroup; bP < 0.05, compared with 2nd trimester subgroup; cP < 0.05, compared with 3rd trimester subgroup