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Table 3 General characteristics and pregnancy outcomes of patients with different endometrial preparation protocols after PSM

From: Retrospective analysis of the endometrial preparation protocols for frozen-thawed embryo transfer cycles in women with endometriosis

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NC and GnRHa-HRT after PSM

HRT and GnRHa-HRT after PSM

NC

GnRHa-HRT

P value

HRT

GnRHa-HRT

P value

No. Of cases

312

312

-

332

332

-

Maternal age at FET, years

32.27ā€‰Ā±ā€‰3.46

32.18ā€‰Ā±ā€‰3.56

0.959

32.12ā€‰Ā±ā€‰3.47

32.3ā€‰Ā±ā€‰3.52

0.479

Duration of infertility, years

3.68ā€‰Ā±ā€‰2.44

3.8ā€‰Ā±ā€‰2.5

0.562

3.61ā€‰Ā±ā€‰2.56

3.68ā€‰Ā±ā€‰2.47

0.542

Body mass index, kg/m2

20.52ā€‰Ā±ā€‰2.36

20.6ā€‰Ā±ā€‰2.47

0.52

20.73ā€‰Ā±ā€‰2.27

20.66ā€‰Ā±ā€‰2.38

0.707

Infertility diagnosis

Primary infertility, n (%)

60.6%(189/312)

63.5%(198/312)

0.73

59.3%(197/332)

59.3%(197/332)

0.969

Secondary infertility, n (%)

38.1%(119/312)

35.6%(111/312)

38%(126/332)

38.3%(127/332)

Infertility-free

1.3%(4/312)

1%(3/312)

2.7%(9/332)

2.4%(8/332)

Infertility etiology, n (%)

Tubal factor

58%(181/312)

54.2%(169/312)

0.333

55.4%(184/332)

50.9%(169/332)

0.243

Male factor

47.8%(149/312)

47.4%(148/312)

0.936

52.4%(174/332)

50.6%(168/332)

0.641

Other

27.9%(87/312)

30.8%(96/312)

0.429

32.8%(109/332)

34.3%(114/332)

0.681

endometriosis ASRM stage

ASRMI-II

22.1%(69/312)

21.2%(66/312)

0.771

18.7%(62/332)

19.6%(65/332)

0.767

ASRMIII-IV

77.9%(243/312)

78.8%(246/312)

81.3%(270/332)

80.4%(267/332)

endometriosis complicated with adenomyosis

6.7%(21/312)

6.1%(19/312)

0.744

6.9%(23/332)

6%(20/332)

0.636

Ovarian stimulation protocols, n (%)

Long GnRH-a

66%(206/312)

66.3%(207/312)

0.986

64.5%(214/332)

64.2%(213/332)

0.951

GnRH-a

ultra-long

5.1%(16/312)

4.8%(15/312)

6.9%(23/332)

6.3%(21/332)

GnRH antagonist

21.2%(66/312)

20.5%(64/312)

19.9%(66/332)

21.4%(71/332)

Other protocols

7.7%(24/312)

8.3%(26/312)

8.7%(29/332)

8.1%(27/332)

Gonadotropin dose, IU

2338.82ā€‰Ā±ā€‰878.17

2532.28ā€‰Ā±ā€‰966.03

0.009a

2471.42ā€‰Ā±ā€‰936.87

2533.49ā€‰Ā±ā€‰979.57

0.433

No. of oocytes retrieved

12.99ā€‰Ā±ā€‰7.84

13.37ā€‰Ā±ā€‰7.84

0.358

13.08ā€‰Ā±ā€‰8.15

12.6ā€‰Ā±ā€‰7.76

0.615

Blastocyst formation rate

0.61ā€‰Ā±ā€‰0.29

0.59ā€‰Ā±ā€‰0.26

0.389

0.60ā€‰Ā±ā€‰0.27

0.60ā€‰Ā±ā€‰0.28

0.936

Type of embryo transferred, n (%)

Cleavage embryo

44.9%(140/312)

45.5%(142/312)

0.872

47.9%(159/332)

47.6%(158/332)

0.938

Blastocyst

55.1%(172/312)

54.5%(170/312)

52.1%(173/332)

52.4%(174/332)

No. of embryos transferred

1.69ā€‰Ā±ā€‰0.66

1.59ā€‰Ā±ā€‰0.56

0.036a

1.71ā€‰Ā±ā€‰0.62

1.60ā€‰Ā±ā€‰0.55

0.018a

No. of good quality embryos transferred

1.11ā€‰Ā±ā€‰0.69

1.14ā€‰Ā±ā€‰0.71

0.573

1.18ā€‰Ā±ā€‰0.69

1.17ā€‰Ā±ā€‰0.71

0.814

Rate of good quality embryos transferred

81.7%(255/312)

82.4%(257/312)

0.835

84.3%(280/332)

83.1%(276/332)

0.674

Clinical Pregnancy

48.1%(150/312)

53.5%(167/312)

0.173

52.1%(173/332)

50.9%(169/332)

0.756

Live Birth

41.7%(130/312)

43.6%(136/312)

0.627

42.2%(140/332)

43.1%(143/332)

0.814

Early Miscarriage

12.7%(19/150)

15%(25/167)

0.554

17.9%(31/173)

11.8%(20/169)

0.114

  1. Note: aP<0.05