Table 1 General characteristics and clinical outcomes of patients with different endometrial preparation protocols

No. of cases

451

696

42

859

-

Maternal age at FET, years

32.29 ± 3.49

32.11 ± 3.53

32.71 ± 3.49

32.29 ± 3.40

0.551

Duration of infertility, years

3.50 ± 2.34

4.02 ± 2.67

3.74 ± 2.36

4.12 ± 2.68

0.001^a

Body mass index, kg/m2

20.75 ± 2.45

20.80 ± 2.48

21.25 ± 2.83

20.69 ± 2.42

0.607

Infertility diagnosis

Primary infertility, n (%)

61.2%

(276/451)

54.7%

(381/696)

40.5%

(17/42)

59.4%

(510/859)

0.001^a

Secondary infertility, n (%)

36.1%(163/451)

43.5%(303/696)

54.8%(23/42)

40%(344/859)

Infertility-free^b

2.7%(12/451)

1.7%(12/696)

4.8%(2/42)

0.6%(5/859)

Infertility etiology, n (%)

Tubal factor

51.2%(231/451)

56.8%(395/696)

61.9%(26/42)

63.7%(547/859)

0.000^a

Male factor

49.7%(224/451)

47.6%(331/696)

57.1%(24/42)

47.4%(407/859)

0.556

Other

33.9%(153/451)

35.5%(247/696)

19%(8/42)

24.9%(214/859)

0.000^a

endometriosis ASRM stage^c

ASRMI-II

14.6%(66/451)

45.7%(318/696)

50%(21/42)

51.2%(440/859)

0.000^a

ASRMIII-IV

85.4%(385/451)

54.3%(378/696)

50%(21/42)

48.8%(419/859)

endometriosis complicated with adenomyosis

20.4%(92/451)

3.6%(25/696)

14.3%(6/42)

3.3%(28/859)

0.000^a

Ovarian stimulation protocols, n (%)

Long GnRH-a

55.2%(249/451)

74.1%(516/696)

69%(29/42)

79.6%(684/859)

0.000^a

GnRH-a ultra-long

12.4%(56/451)

4%(28/696)

0%(0/42)

2.1%(18/859)

GnRH antagonist

24.8%(112/451)

15.1%(105/696)

26.2%(11/42)

12.2%(105/859)

Other protocols

7.5%(34/451)

6.8%(47/696)

4.8%(2/42)

6.1%(52/859)

Gonadotropin dose, IU

2621 ± 945

2325 ± 894

2748 ± 1038

2300 ± 848

0.000^a

No. of oocytes retrieved

12.15 ± 7.53

15.09 ± 8.9

14.5 ± 9.35

15.29 ± 8.43

0.000^a

Blastocyst formation rate

0.60 ± 0.28

0.56 ± 0.28

0.59 ± 0.28

0.56 ± 0.29

0.313

Type of embryo transferred, n (%)

Cleavage embryo

45.0%(203/451)

42.1%(293/696)

35.7%(15/42)

45.5%(391/859)

0.365

Blastocyst

55.0%(248/451)

57.9%(403/696)

64.3%(27/42)

54.5%(468/859)

No. of embryos transferred

1.58 ± 0.57

1.71 ± 0.65

1.48 ± 0.51

1.78 ± 0.68

0.000^a

No. of good quality embryos transferred

1.15 ± 0.69

1.13 ± 0.78

0.93 ± 0.75

1.12 ± 0.78

0.287

Rate of good quality embryos transferred

83.8%(378/451)

78.3%(545/696)

69%(29/42)

78.9%(678/859)

0.033^a

Clinical Pregnancy

53.2%(240/451)

49.7%(346/696)

54.8%(23/42)

46.8%(402/859)

0.141

Live Birth

43.5%(196/451)

39.8%(277/696)

45.2%(19/42)

39.0%(335/859)

0.397

Early Miscarriage

15.4%(37/240)

18.2%(63/346)

17.4%(4/23)

15.4%(62/402)

0.732