Fig. 2

MicroRNAs universally regulating endometrial progression and function and their expression throughout the menstrual cycle. A Regulatory network of miRNAs forming relationships with numerous gene lists (2–12); miRNAs targeting specific gene lists were placed in the centre of the network. The prioritized miRNAs (outlined in red) included has-miR-16-5p, has-miR-138-5p, has-miR-21-3p, has-miR-205-5p, has-miR-27a-5p, has-miR-15a-5p, has-miR-155-5p, has-miR-129–2-3p, has-miR-147a, has-miR-146a-5p, has-miR-107, has-miR-424-5p, has-miR-203a-3p, has-miR-195-5p, has-miR-124-3p, has-miR-128-3p, has-miR-22-3p, has-miR-27b-3p, has-let-7b-5p, has-miR-1343-3p, has-miR-1-3p, has-miR-103a-3p, has-miR-23b-3p, has-miR-218-5p. B Expression profiles of the 10 prioritized miRNAs at different phases of the menstrual cycle. Significant changes between phases are denoted with asterisks (* FDR ≤ 0.05, ** FDR ≤ 0.01. Abbreviations: EPF, early proliferative phase; LPF, late proliferative phase; ESE, early-secretory phase; MSE, mid-secretory phase; LSE, late-secretory phase