Fig. 5
From: Loss of ACTL7A causes small head sperm by defective acrosome-acroplaxome-manchette complex
The infertility of Actl7a-KO mice can be successfully rescued by ICSI-AOA. (A) The oocytes were fertilized by the sperms from the Actl7a-KO mice after AOA. The sperms of the Actl7a-KO mice failed to fertilize the normal oocytes by ICSI (lane 2). However, the combination of ICSI and AOA enabled the sperms of the Actl7a-KO mice to successfully fertilize the oocytes and develop into blastocysts (lane 3). (B) The offspring of the Actl7a-KO mice were born after ICSI-AOA. (C) Genotyping for the newborn pups of Actl7a-KO mice. +/KO, heterozygous mutation