Fig. 1

Effect of 5-HT concentration on umbilical intravascular pressure and lactate production. Adding 5-HT to the fetal circulation increased the intravascular pressure in the umbilical arteries (A) and lactate production in the fetal circuit (B). Data are presented for individual biological replicates with lines connecting median values; n = 5. Statistical significance was evaluated using a mixed effects model with the Geisser-Greenhouse correction and Dunnett’s multiple comparisons test. * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001