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Table 1 Patients’ demographic characteristics and IVF cycle-related variables of the PPOS and GnRH antagonist treatment groups

From: Progestin Primed Ovarian Stimulation (PPOS) protocol yields lower euploidy rate in older patients undergoing IVF

  

All patients

  

Age < 38

  

Age ≥ 38

 
 

PPOS N = 34 (cycles)

Antagonist N = 94 (cycles)

P Value

PPOS N = 15 (cycles)

Antagonist N = 47 (cycles)

P Value

PPOS N = 19 (cycles)

Antagonist N = 47 (cycles)

P Value

Age (years)

37.9 ± 4.5

37.3 ± 4.4

0.540

33.4 ± 2.2

33.8 ± 2.9

0.656

41.1 ± 1.9

40.9 ± 2.0

0.350

BMI (kg/m2)

23.14 ± 3.86

22.59 ± 3.09

0.410

22.78 ± 4.4

22.63 ± 2.83

0.877

23.42 ± 3.49

22.55 ± 3.35

0.350

Infertility years

3.2 ± 2.2

3.5 ± 2.0

0.468

2.1 ± 0.9

3.4 ± 1.9

0.019

4.1 ± 2.5

3.7 ± 2.1

0.503

AMH (ng/ml)

2.56 ± 1.83

2.56 ± 2.1

0.986

3.056 ± 2.206

2.905 ± 2.351

0.839

2.166 ± 1.420

2.299 ± 1.871

0.790

Gonadotropin dose (IU)

2269.06 ± 768.93

2200.72 ± 545.05

0.664

1417.60 ± 954.12

2204.59 ± 643.19

0.0022

2596.54 ± 340.45

2197.44 ± 454.61

0.006

Day of trigger

10.9 ± 1.7

9.3 ± 1.2

 < 0.001

11.1 ± 1.9

9.4 ± 1.2

 < 0.001

10.8 ± 1.5

9.3 ± 1.2

 < 0.001

Day 3 FSH (IU/L)

7.54 ± 2.76

8.08 ± 2.78

0.330

7.15 ± 2.33

8.42 ± 3.17

0.162

7.84 ± 3.09

7.76 ± 2.33

0.911

Day 3 LH (IU/L)

4.68 ± 2.14

4.7 ± 2.36

0.968

5.15 ± 1.92

4.50 ± 2.21

0.311

4.31 ± 2.28

4.90 ± 2.52

0.381

LH on trigger day (IU/L)

4.79 ± 4.02

4.48 ± 3.59

0.689

4.40 ± 4.70

4.54 ± 3.81

0.923

5.08 ± 3.45

4.42 ± 3.39

0.494

E2 on trigger day (pg/ml)

2314.9 ± 1956.5

1505.8 ± 1166.2

0.008

2630.4 ± 1692.0

1526.0 ± 1067.6

0.006

2065.9 ± 2154.7

1484.4 ± 1276.3

0.210

Oocytes retrieved

12.2 ± 8.3

12 ± 8.9

0.928

16.1 ± 9.7

12.3 ± 10.2

0.214

9.1 ± 5.6

11.7 ± 7.5

0.176

MII rate (%)

86.6 ± 2.7*

80.0 ± 1.7*

0.004

87.4 ± 3.7*

78.0 ± 2.8*

0.075

89.5 ± 3.8*

81.9 ± 2.1*

0.024

Fertilization rate (%)

79.0 ± 5.3*

76.4 ± 2.6*

0.832

87.1 ± 9.0*

80.4 ± 4.2*

0.463

72.7 ± 6.1*

72.5 ± 3.0*

0.975

Blastocyst rate (%)

53.6 ± 4.5*

63.5 ± 2.5*

0.042

63.5 ± 5.7*

67.1 ± 3.2*

0.454

45.8 ± 6.1*

59.9 ± 3.8*

0.036

Euploidy rate (%)

17.0 ± 4.6*

31.8 ± 3.5*

0.027

27.4 ± 6.2*

39.4 ± 5.4*

0.245

8.3 ± 6.1*

24.0 ± 4.2*

0.003

  1. Data are expressed as mean ± SD or frequency (%)
  2. * mean ± standard error of the means (SEM)
  3. BMI Body mass index, AMH  Anti-Müllerian hormone
  4. FSH  Follicle stimulating hormone, LH Luteinizing hormone, E2 Estradiol, MII Metaphase II