Table 1 Characteristics of included studies
Included studies | Country | Sample size (I/C) | Duration of infertility [y, mean (SD)] (I/C) | BMI [kg/m2] (I/C) | Age [y, mean (SD)] (I/C) | Diagnostic criteria | Intervention (dose/duration) | Control | Outcomes |
|---|---|---|---|---|---|---|---|---|---|
Hu R, 2018 | China | 41/37 | 5(4.60)/4.67(3.84) | 21.67(2.81)/22.45(3.12) | 37.33 (3.07)/36.67 (3.86) | Bologna | DHEA (25 mg, tid/3 m) | FSH 300 ~ 450 IU/d, on day 2 ~ 3 of the menstrual cycle; HCG 6000 ~ 10,000 IU | ①②③④ |
Li XL, 2018 | China | 32/40 | 4.18(2.95)/4.66(2.93) | 22.70(2.86)/21.94(2.79) | 33.13 (4.70)/32.85 (5.31) | Bologna | GH (4 IU, qd/ day 2–3 of the menstrual cycle t to the day of HCG) | one week after ovulation, triptorelin, 0.1 mg/d and changed to 0.5 mg/d after 1–2 weeks; HCG 10,000 IU | ①②③⑥⑤ |
Liao CR, 2017 | China | 56/47 | 7.25(3.85)/8.29(3.42) | —— | 37.90 (3.08)/ 38.05 (2.35) | Bologna | DHEA (25 mg, tid/3 m) | Gonal-F, 150 ~ 225 U/d, on day 3 of the menstrual cycle; Cetrorelix, 0.25 mg/d; HCG 10,000 IU | ①④⑥ |
Song H, 2015 | China | 56/56 | 5.85(2.12)/6.28(1.83) | —— | 37.14 (5.21)/36.86 (5.72) | Bologna | DHEA (25 mg, tid/3 m) | HCG 6000 ~ 10000U | ①②③④⑥ |
Tang Y, 2013 | China | 21/17 | 9.6(1.1)/7.6(0.8) | —— | 34.5 (0.7)/32.8 (1.2) | Bologna | GH (4 IU, qd/ day 2–3 of the menstrual cycle t to the day of HCG) | triptorelin, 0.05 mg/d, 1 ~ 2 day after ovulation; Gonal-F, 300IU/d, 2 ~ 3 day after ovulation; HCG 5000 ~ 10,000 IU | ①|
Wu XY, 2018 | China | 48/48 | 3.5(1.50)/3.7(1.10) | 24.1(2.60)/23.7(1.80) | 36.4 (3.70)/37.3 (2.90) | Bologna | GH (4.5 IU, qd/ day 2–3 of the menstrual cycle t to the day of HCG) | Gn, 225 ~ 375 IU/d; GnRH-A, 0.25 mg/d, on day 2 ~ 3 of the menstrual cycle; HCG, 250 mg | ①②⑥ |
Xu Y, 2018 | China | 76/93 | 3(1.54)/2.67(0.76) | 21.85(2.51)/22.24(3.07) | 32.50 (3.30)/31.92 (3.68) | Bologna | CoQ10(200 mg, tid/ 60 d) | Gonal-F and HMG, both 225 IU/d, on day 2 of the menstrual cycle; Cetrorelix 250 μg/d; Ovidrele 250 μg | ①⑤⑥ |
Safdarian L, 2019 | Iran | 34/26 | 3.71(1.63)/3.16(1.62) | 26.43(3.24)/26.63(3.07) | 33.80 (4.66)/33.91 (4.49) | Bologna | GH (2.5 mg, qd/ day 8 of the menstrual cycle t to the day of HCG) | Gonal-F, 300 ~ 450 IU/d, on day 3 of the menstrual cycle; Cetrotide, 0.25 mg/d; HCG 10,000 IU | ①⑥⑤ |
Gong Y, 2020 | China | 52/53 | 4.57(3.14)/4.39(3.22) | 22.09(1.73)/22.62(2.73) | 38.41 (2.91)/38.20 (2.79) | Bologna | GH (4 IU, qd/ day 2 of the menstrual cycle t to the day of HCG) | Gonal-F/on day 2 of the menstrual cycle; Ganirelix; HCG | ①②③④⑥ |
Mi H, 2014 | China | 32/32 | 4.31 (0.60)/ 4.75(0.58) | 23.11 (0.73)/ 24.31(0.53) | 38 (0.92)/ 37.8 (0.55) | Bologna | TEAS (2 Hz, 20–25 mA, 30 min, qd/ 3 m) | Estradiol valerate tablets/2 mg po qd, 21 days, on the fifth day of menstruation; Dydrogesterone Tablets/10 mg po bid, 5 days, 3 periods | ①②③④⑥ |
Lian F, 2017 | China | 46/46 | 4.03(1.62)/4.28(1.57) | —— | 40.18 (2.82)/ 40.06 (2.62) | Bologna | TEAS (2 Hz, 20–25 mA, 30 min, qd/ 1 m) | HMG, 150 ~ 300 IU/d, on day 2 ~ 4 of menstruation; Cetrorelix Acetate, 0.125 ~ 0.25 mg/d; HCG 5000 ~ 10,000 IU | ①③⑥ |
Bassiouny YA, 2016 | Egypt | 68/73 | 6.44(3.62)/6.75(3.75) | 23.71(5.06)/22.67(3.71) | 35.79 (5.56)/35.53 (5.98) | Bologna | GH (7.5 IU, qd/ day 6 of hMG stimulation until the day of hCG triggering) | HMG, 300–450 IU/d, from the second day of the cycle; Cetrotide, 0.25 mg/d; HCG 10,000 IU | ①②⑤ |
Wang Z, 2021 | China | 410/411 | 3.33(3.72)/3.17(3.72) | 23.83(3.16)/24.01(3.07) | 39.00 (4.64)/39.53 (4.39) | Bologna | DHEA (25 mg, tid/4–12 w) | Triptorelin, 0.05 ~ 0.1 mg/on day 2 ~ 3 of menstruation; Menotropins, 150 ~ 225 IU/d; HCG 4000 ~ 10,000 IU | ①⑤ |
Kotb MMM, 2016 | Egypt | 70/70 | 7.9(2.5)/7.6(2.6) | 25.6(3.4)/25.1(3.4) | 40.05 (3.1)/39.7 (0.5) | Bologna | DHEA (25 mg, tid/3 m) | HMG, 300 ~ 450 IU/d, on the second day of menstruation; Cetrotide 0.25 mg/d; HCG 10,000 IU | ①④ |
Choe SA, 2018 | South Korea | 62/65 | 3.85(2.69)/4.49(3.57) | 21.2(2.5)/21.1(2.4) | 39.8 (3.6)/39.4 (4.1) | Bologna | GH (20 mg/ three times, mid-luteal, late luteal, and menstrual cycle day 2) | Gonal-F, 225 ~ 375 IU/from menstrual day 3; Cetrotide, 0.25 mg/d; HCG | ①③⑥ |
Mohammad EH, 2021 | Egypt | 78/78 | 6.62(2.13)/6.35(2.01) | 24.39(1.52)/25.06(3.47) | 34.27 (2.41)/34.74 (1.98) | Bologna | GH (4 IU,qd/ from the second day of the cycle and stopped one day before ovum pickup) | Cetrorelix, 0.25 mg/d, started on day 6 of COH; HCG 10,000 IU | â‘ â‘¡ |