Fig. 6
From: Paternal Expressed Gene 10 (PEG10) is decreased in early-onset preeclampsia
Effect of silenced PEG10 on cytotrophoblast function. Following transfection with luciferase reporter plasmid containing four copies of the SMAD binding element, PEG10-siRNA hTSCs had reduced basal levels of canonical TGF \(-\beta\) signalling relative to negative siRNA controls (A). Real-time analysis of cell proliferation showed no effect of PEG10 siRNA (pink) relative to control siRNA treated cells (black) (B). Dotted line in panel B indicates time of siRNA treatment, dashed line indicates time of media change. Data expressed as median with interquartile range. P* < 0.05