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Table 3 Reproductive indices of Control and Aspartame (ASP) treated female mice after 30 and 60 days

From: The impact of non-caloric artificial sweetener aspartame on female reproductive system in mice model

Parameters

Group

Duration (days)

30 days

60 days

Fertility index (FI)

Control

100%

100%

ASP

80%

60%

Gestation period

Control

20.6 ± 1.14

20.8 ± 0.84

ASP

19.2 ± 0.84 NS

19.4 ± 0.55 NS

Litter size

Control

7.4 ± 0.55

7.6 ± 0.55

ASP

5.8 ± 0.45*

5.4 ± 0.89**

Litter weight (g)

Control

1.55 ± 0.09

1.57 ± 0.08

ASP

1.40 ± 0.04*

1.34 ± 0.07**

Postnatal viability index

Control

100%

100%

ASP

96.55%

96.29%

Weaning index

Control

97.29%

100%

ASP

93.10%

92.59%

  1. ± SD of six animals
  2. *Significant difference (p ≤ 0.05) compared to control by one way ANOVA
  3. **More significant difference (p ≤ 0.01) compared to control by one way ANOVA
  4. ***Highly significant difference (p ≤ 0.001) compared to control by one way ANOVA
  5. NS Non significant compared to control by one way ANOVA