Table 2 Main characteristics of studies included in the meta-analysis
Author | Location of study | Study type | Sample size (SI/LI) | Mean age (years) | controlled ovarian stimulation protocol (s) | ART | Duration of infertility (years) | Causes of infertility | Dose of hCG |
|---|---|---|---|---|---|---|---|---|---|
Skvirsky S et al. (2021) [27] | Israel | Retrospective cohort study | 485(482/3) | SI: 34.9 ± 5.6 LI: 35.8 ± 8.0 | GnRH agonist/ GnRH antagonist | IVF/ICSI | NA | NA | 250 μg, subcutaneously |
Bao L et al. (2019) [26]a | China | Retrospective cohort study | 199(78/121) | SI: 28.95 ± 3.09 LI: 28.89 ± 3.43 | GnRH agonist | IVF/ICSI | SI:3.82 ± 1.86 LI:3.74 ± 2.10 | NA | 250 μg, subcutaneously |
Chen YY et al. (2014) [25]a | China | Retrospective cohort study | 1500(1337/163) | SI: NA LI: 30.232 ± 3.879 | GnRH agonist | IVF/ICSI | NA | NA | 5 000 ~ 10 000 IU, IM |
Ghasemian F et al. (2013) [24] | Iran | Retrospective cohort study | 126(65/61) | NA | GnRH agonist | ICSI | NA | NA | 10,000Â IU, NA |
Gong SQ et al. (2012) [23]a | China | Retrospective cohort study | 173(41/132) | SI: 33.93 ± 3.44 LI: 31.22 ± 3.70 | GnRH agonist | IVF/ICSI | SI:4.31 ± 2.87 LI:4.11 ± 2.43 | NA | 6 000 ~ 10 000 IU, IM |
Raziel A et al. (2006) [22] | Israel | Quasi-randomized trial study | 72(36/36) | 31.3 ± 4.9 | GnRH agonist | ICSI | 5 ± 3.6 | Primary infertility | 5000 IU, IM |
Bokal EV et al. (2005) [21] | Slovenia | Prospective cohort study | 20(9/11) | 30.9 ± 3.1 | GnRH agonist | IVF/ICSI | NA | NA | 10,000 IU, NA |
Nargund G et al. (2001) [13] | England | Randomized study | 369 (258/111) | 33.4 | GnRH agonist | IVF | NA | Tubal damage, male factor, and unexplained infertility | 10,000Â IU, NA |
Bjercke S et al. (2000) [20] | Norway | Randomized study | 170 (83/87) | SI: 35 LI: 33 | GnRH agonist | IVF | NA | Tubal factor | 10,000Â IU, subcutaneously |
Mansour RT et al. (1994) [9] | Egypt | Randomized study | 90(60/30) | SI: NA LI: 31.2 ± 2.3 | GnRH agonist | ICSI | NA | Male factor | 10,000 IU, IM |
Jamieson ME et al. (1991) [19] | Scotland | Randomized study | 60 (30/30) | NA | GnRH agonist | IVF | NA | Tubal factor or unexplained infertility | 5000Â IU, NA |
Thornton SJ et al. (1990) [18] | Australia | Quasi-Randomized study | 214 (108/106) | NA | CC | IVF | NA | NA | 5,000Â IU, NA |