Fig. 2
From: Psychoactive drugs and male fertility: impacts and mechanisms
Effects of psychoactive drugs on sexual function and fertility indices. Psychoactive drugs usually act as stimulants or depressants irrespective of their classes. Depressants have been reported to suppress (red arrow) sexual urge, sexual and erectile function, and sexual satisfaction via downregulation of circulating androgen and stimulatory neuroendocrine like dopamine, resulting in reduced fertility indices. On the other hand, although stimulants may elicit increased (green arrow) sexual urge, sexual and erectile function, and sexual satisfactory via a testosterone-independent signaling, they also induce reduced fertility indices