Table 1 Literature collection of mitochondrial DNA alterations in different adverse fertility-related factors
Mitochondrial DNA (mtDNA) alterations | Aging | Assisted reproductive technology (ART) | Diabetes | Obesity | ||
|---|---|---|---|---|---|---|
Controlled ovarian hyperstimulation (COH) | In vitro maturation and culture | Mitochondria replacement technology (MRT) | Â | Â | ||
Quantitative alterations, including the changes of mitochondria number | Human [7, 9, 52,53,54,55,56, 64] Bovine [65] | Human [90] Golden hamsters [81] | Mice [91] Rats [83] Equine [89] | Â | Mice [67] | |
Qualitative alterations: mtDNA mutations (point mutations, deletions, insertions, duplications and rearrangements) and the expression of mtDNA | Human [12, 56,57,58,59, 61, 63] Bovine [60] | Mice [80] Rhesus macaques [79] | Mice [93] Rhesus macaques [86] Bovine [85] | Human [100] | Â | Â |