Table 2 Meta-analysis results for the two studied polymorphisms and RPL risk
Gene polymorphism | Inherited model | Heterogeneity-test | Analysis modela | Pooled OR (95% CI) | P | |
|---|---|---|---|---|---|---|
P for Q test | I 2 (%) | |||||
-238G/A | Codominant (A vs. G) | 0.001 | 80.7 | REM | 0.996 [0.932,1.065] | 0.912 |
Homozygous (AA vs. GG) | 0.017 | 70.7 | REM | 0.830 [0.238, 2.887] | 0.769 | |
Heterozygous (AA vs. GA) | 0.175 | 39.5 | FEM | 0.888 [0.54, 1.46] | 0.640 | |
Dominant(AA+GA vs. GG) | 0.007 | 75.2 | REM | 0.908 [ 0.566, 1.456] | 0.690 | |
Recessive(AA vs. GA+GG) | 0.036 | 64.9 | REM | 1.212 [ 0.394, 3.729] | 0.737 | |
-308G/A | Codominant (A vs. G) | 0.017 | 63.6 | REM | 0.737 [0.539, 1.01] | 0.057 |
Homozygous (AA vs. GG) | 0.713 | 0 | FEM | 0.445 [0.268, 0.741] | 0.002 | |
Heterozygous (AA vs. GA) | 0.658 | 0 | FEM | 0.519 [0.303, 0.89] | 0.017 | |
Dominant(AA+GA vs. GG) | 0.018 | 54.8 | REM | 0.836 [0.622, 1.124] | 0.236 | |
Recessive(AA vs. GA+GG) | 0.774 | 0 | FEM | 2.141 [1.291, 3.55] | 0.003 | |