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Table 3 Relation of POF (UMLS ID: C0085215) with other diseases that significantly share GWAS/OMIM/DEG genes [5]

From: Infertility etiologies are genetically and clinically linked with other diseases in single meta-diseases

Diseases

P value a

Hypergonadotropic ovarian failure, X linked

<0.0001

Premature menopause

<0.0001

Fragile X tremor/ataxia syndrome

<0.0001

POF7 (disorder)

<0.0001

Spermatogenic failure 8

<0.0001

Hypoaldosteronism

<0.0001

Sex chromosome disorders

<0.0001

Adrenal cortical hypofunction

<0.0001

Fragile X syndrome

<0.0001

Adrenal gland hypofunction

0.0001

Adrenal gland diseases

0.0005

POF5

0.0008

POF6

0.0008

POF2b

0.0008

Sex chromosome aberrations

0.0008

Ptosis

0.0016

Uterine prolapse without mention of vaginal wall prolapse

0.0016

Eyelid diseases

0.0024

Blepharophimosis

0.0040

Blepharoptosis

0.0071

  1. aA hypergeometric test was applied by DiseaseConnect [5] to assess the significance of the GWAS/OMIM/DEG genes shared by POF and a particular disease.