Levels of soluble fms-like tyrosine kinase one in first trimester and outcomes of pregnancy: a systematic review

Table 3 Results from studies assessing the association between 1^st trimester sFlt-1 concentrations (pg/mL) and preeclampsia (PE)

Reference	Mean GA	Outcome	Cases (Preeclampsia)		Controls (normotensive)		P-value	% difference†
			n	Flt-1 concentration	n	sFlt-1 concentration
Studies reporting mean concentrations				mean, SD/SE		mean, SD/SE
Baumann, 2008	12.3	PE (> 34 weeks)	46	1764 (757)	92	1537 (812)	0.04	+13
Chaiworapongsa, 2005	12.3	PE	34	546 (271)	37	464 (260)	0.10	+15
Lynch, 2010	12.3	PE	31	1374 (639)	637	1313 (521)	0.5	+5
Noori, 2010	13.7	PE (< 37 weeks)	10	2414 (622)	128	1729 (85)	< 0.01	+40
		PE (≥ 37 weeks)	10	1688 (210)	128	1729 (85)	0.19	- 2
Rana S, 2007	11-13*	PE	39	3500 (300)	147	3000 (100)	0.14	+14
Thadhani, 2004	10.7	PE	40	1048 (657)	80	973 (490)	> 0.05	+ 7
Vatten, 2007	9.0	Preterm PE	110	135	276	166	0.01	-19
Studies reporting median concentrations				median		median
Akolekar 2010	11-13*	PE (< 34 weeks)	30	7099	180	6349	NS	+12
		PE (≥ 34 weeks)	60	6840	180	6349	NS	+ 8
Erez, 2008	12.2	PE (< 37 weeks)	17	1308	201	1788	0.03	-27
	12.2	PE (≥ 37 weeks)	39	1448	201	1788	0.02	-19
Wathen, 2006	13.7	PE	44	481	51	432	> 0.05	+10

*No mean gestational age (GA) provided
† % difference in case mean or median 1^st trimester sFLT-1 compared with the control level

ISSN: 1477-7827