Table 1 Characteristics of studies assessing sFlt-1 in first trimester of pregnancy
Reference | Location | Study Design | Type of sample and gestational age at screening | Participants | Outcome(s) | s-FLT1 Summary measure |
|---|---|---|---|---|---|---|
Akolekar, 2010 | United Kingdom | nested case-control | Plasma 11-13 weeks | Singleton pregnancies Exclusions: hypertension but uncertainty about a diagnosis of preeclampsia (n = 30), preeclampsia but stored blood not available (n = 57) | Preeclampsia < 34 weeks ≥ 34 weeks | median |
Baumann, 2008 | Switzerland | case-control | Serum 11-14 weeks | Singleton pregnancies Exclusions: women with history of hypertensive disorders, immunological diseases, HELLP, or PE < 34 weeks | Preeclampsia | mean, median |
Chaiworapongsa, 2005 | Chile | case-control | Plasma 7-16 weeks | Singleton pregnancies. Exclusions: pregnancies with fetal anomaly or demise, vaginal bleeding, women with serious medical conditions, chronic hypertension, asthma requiring medication, or requiring the use of anti-platelet or non-steroidal anti-inflammatory drug. | Preeclampsia | mean |
Erez, 2008 | Chile | nested case-control | Plasma 6-15 weeks | Singleton pregnancies. | SGA Preeclampsia (preterm and term) | median, OR |
Eskild, 2008 | Norway | nested case-control | Serum 4-12 weeks | Normotensive pregnant women only. | Excessive postpartum bleeding | mean |
Lynch 2010 | USA 2005-2008 | prospective cohort | Serum 10-15 weeks | Singleton pregnancies, women presenting for prenatal care Exclusions: intrauterine fetal loss, gestational hypertension | Preeclampsia | mean |
Noori 2010 | United Kingdom | prospective cohort | Serum 10-17 weeks | Singleton pregnancies from routine screening (n = 114) and an obstetric medicine clinic (n = 45) | Preeclampsia, (preterm and term) Gestational hypertension | geometric mean |
Rana S, 2007 | USA 2001-2003 | nested case-control | Serum 11-13 weeks | Singleton pregnancies delivered > 20 weeks (livebirths) gestation. Exclusions: women with history of hypertension, hypertension 6 weeks postpartum, renal disease, or diabetes. | Preeclampsia | mean |
Smith, 2007 | Scotland 1997-99 | nested case-control | Serum 10-14 weeks | Singleton pregnancies. Exclusions: stillbirths due to congenital anomalies or rhesus disease. | Preeclampsia SGA Preterm (extreme and moderate) Stillbirth | OR |
Thadhani R, 2004 | USA 2001-2003 | nested case-control | Serum 8-14 weeks | Singleton pregnancies > 20 weeks gestation. Exclusions: women with hypertension > 6 weeks postpartum, history of thyroid, liver, or chronic renal disease, or chronic hypertension. | Preeclampsia, Gestational hypertension SGA | mean |
Vatten LJ, 2007 | Norway 1992-1994 | nested case-control | Serum 4-12 weeks | Singleton pregnancies | Preeclampsia (preterm and term) | mean, OR |
Wathen KA, 2006 | Finland 2001-2002 | longitudinal case-control | Serum 2-15 weeks | Singleton pregnancies among Caucasian women Exclusions: women with history of hypertension, diabetes, chronic disease, or smoke > 5 cigarettes/day. | Preeclampsia IUGR | median, OR |