Observation | Potential clinical relevance |
---|---|
Different androgens affect ovarian follicles in varying ways | May explain positive and negative effects reported in literature; Different androgens can be expected to have different clinical effects. |
Androgens will affect follicles differently at varying concentrations | Same as above |
Androgens affect ovaries through genomic (AR) and non-genomic signaling | Â |
• Most affected cell type: granulosa cells | Granulosa cell abnormalities should be associated with POF and other ovarian function abnormalities |
• Most affected maturation stage: preantral and early antral follicles | Androgen effects should be visible in AMH levels and AFCs |
Androgens activate FSH activity on granulosa cells the most at antral stage | Antral stage should be most responsive to synergistic activity of androgens and FSH |