Impact of methoxyacetic acid on mouse Leydig cell gene expression

Table 3 Gene functional clusters affected by MAA for each sub-group

Response	Top term	Enrich-ment score	Cluster gene count	p-value
Early transient	GO:0045449, Regulation of transcription	5.96	106	3.23E-07
	GO:0044424, Intracellular part	5.8	211	1.11E-06
	GO:0065007, Biological regulation	5.54	124	6.15E-07
Early sustained	GO:0050794, Regulation of cellular process	3.41	66	1.85E-04
	IPR000867: Insulin-like growth factor-binding protein, IGFBP	3.04	4	6.28E-04
	Domain: von Willebrand factor, type C	2.91	4	4.81E-04
Early persistent	GO:0048731, System development	2.19	48	1.19E-03
	GO:0048514, Blood vessel morphogenesis	2.13	9	2.17E-03
	GO:0044421, Extracellular region part	2.07	43	6.46E-03
Mid transient	GO:0007155, Cell adhesion	3.11	34	3.28E-04
	GO:0044237, Cellular metabolic process	2.25	347	1.60E-04
	IPR004021: HIN-200/IF120x	2.13	5	9.10E-04
Mid sustained	GO:0044421, Extracellular region part	8.22	109	7.30E-10
	IPR015493: Protocadherin beta	6.56	15	1.68E-12
	IPR003128: Villin headpiece	4.39	5	2.85E-05
Late	GO:0044421, Extracellular region part	10.34	165	5.60E-12
	GO:0048856, Anatomical structure development	4.4	144	1.10E-05
	GO:0044449, Contractile fiber part	3.47	12	1.75E-04

Listed are the top three gene functional clusters affected by MAA as determined using DAVID database. The top term for each cluster, the cluster enrichment score and the number of regulated genes in each cluster are listed.

ISSN: 1477-7827