Table 3 Genes associated with pulmonary development or surfactant that are modulated by sex and/or antiandrogen treatment
From: Gene expression profile of androgen modulated genes in the murine fetal developing lung
Process1 | Symbol | Gene name | Modulation2 |
|---|---|---|---|
LUNG DEVELOPMENT REGULATORS | |||
Shh signaling | Gli1 | GLI-Kruppel family member GLI1 | 17 m>17 f; 18 m>18 f |
Shh signaling | Gli3 | GLI-Kruppel family member GLI3 | 17 m>17 f; 18 m>18 f |
FGF signaling | Fgf10 | Fibroblast growth factor 10 | 17 m>17 f |
TGF-β Signaling | Tgfbr3 | Transforming growth factor, beta re ceptor III | 17 m>17 f |
TGF-β Signaling | Tsc22d1 | TSC22 domain family, member 1 | 17 m>17 f |
TGF-β Signaling | Tgfb2 | Transforming growth factor, beta 2 | 17 flut>17 m |
BMP signaling | Bmpr2 | Bone morphogenic protein receptor, type II | 17 m>17 f; 18 m>18 flut |
BMP signaling | Gdf10 | Growth differentiation factor 10 | 17 m>17 flut |
BMP signaling | Gdf15 | Growth differentiation factor 15 | 17 flut>17 m |
Wnt signaling | Gsk3b | Glycogen synthase kinase 3 beta | 17 m>17 f |
Wnt signaling | Ctnna1 | Catenin (cadherin associated protein), alpha 1 | 17 m>17 f |
Wnt signaling | Tcf4 | Transcription factor 4 | 17 m>17 f |
Wnt signaling | Crebbp | CREB binding protein | 17 m>17 f |
SURFACTANT RELATED GENES | |||
Phosphatidyl cholin synthesis | Lpin2 | Lipin 2 | 17 m>17 f; 18 m>18 f |
Phosphatidyl cholin synthesis | Chka | Choline kinase alpha | 17 m>17 f; 17 m>17 flut; 18 m>18 f; 18 m>18 flut |
Phosphatidyl cholin synthesis | Cds2 | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 | 18 flut>18 m |
Phosphatidyl cholin synthesis | Aytl2 (Lpcat1) | Lysophosphatidylcholine acyltransferase 1 | 17 flut>17 m |
Sphingolipids synthesis | Mgll | Monoglyceride lipase | 17 f>17 m |
Sphingolipids synthesis | Aldh9a1 | Aldehyde dehydrogenase 9, subfamily A1 | 17 f>17 m |
Sphingolipids synthesis | Pnliprp2 | Pancreatic lipase-related protein 2 | 17 f>17 m |
Sphingolipids synthesis | Sgpp1 | Sphingosine-1-phosphate phosphatase 1 | 17 f>17 m |
Sphingolipids synthesis | Dusp11 | Dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) | 17 f>17 m |
Sphingolipids synthesis | Crls1 | Cardiolipin synthase 1 | 17 f>17 m; 18 m>18 f |
Sphingolipids synthesis | Gba | Glucosidase, beta, acid | 17 f>17 m |
Surfactant proteins | Sftpa1 | Surfactant associated protein A1 | 17 flut>17 m; 17 flut>17 f; 18 m>17 m; 18 f>17 f |
Surfactant proteins | Sftpb | Surfactant associated protein B | 17 flut>17 f; 18 m>17 m; 18 f>17 f |
Surfactant proteins | Sftpc | Surfactant associated protein C | 17 flut>17 f; 18 m>17 m; 18 f>17 f; 18 m>18 flut |
Surfactant proteins | Sftpd | Surfactant associated protein D | 18 m>17 m; 18 f>17 f |
SURFACTANT REGULATION | |||
Miscellaneous regulators | Klf5 | Kruppel-like factor 5 | 17 flut>17 m; 17 flut>17 f |
Miscellaneous regulators | Ltbp1 | Latent transforming growth factor beta binding protein 1 | 17 m>17 f |
Miscellaneous regulators | Pten | Phosphatase and tensin homolog | 17 m>17 f; 17 m>17 flut |
Miscellaneous regulators | Magi1 | Membrane associated guanylate kinase, WW and PDZ domain containing 1 | 17 m>17 f |
Miscellaneous regulators | Ptges2 | Prostaglandin E synthase 2 | 17 f>17 m |
IGF signaling | Igfbp2 | Insulin-like growth factor binding protein 2 | 17 m>17 flut |
IGF signaling | Igfbp5 | Insulin-like growth factor binding protein 5 | 17 m>17 flut |
IGF signaling | Igf1 | Insulin-like growth factor 1 | 17 m>17 flut |
IGF signaling | Igfr2 (Fcgr2b) | Fc receptor, IgG, low affinity IIb | 17 m>17 flut |