Table 2 Genes related to hormones, lipid processing, and lung function that are modulated by sex and antiandrogen treatment
From: Gene expression profile of androgen modulated genes in the murine fetal developing lung
Biological function | Gene symbol | Gene name | Expression pattern1 |
|---|---|---|---|
GESTATIONAL DAY 17 | |||
Steroid | Hsd17b12 | Hydroxysteroid (17-beta) dehydrogenase 12 | #2 (m > flut > f) |
Androgen | Ext1 | Exostoses (multiple) 1 | #2 (m > flut > f) |
Glucocorticoid | Glcci1 | Glucocorticoid induced transcript 1 | #5 (m > f > flut) |
Lipid binding | Prkca | Protein kinase c, alpha | #5 (m > f > flut) |
Lipid binding | Ncam1 | Neural cell adhesion molecule 1 | #5 (m > f > flut) |
Lipid binding | Gpc6 | Glypican 6 | #2 (m > flut > f) |
Steroid hormone receptor activity | Nr6a1 | Nuclear receptor subfamily 6, group a, member 1 | #2 (m > flut > f) |
Steroid hormone receptor activity | Nr2c2 | Nuclear receptor subfamily 2, group c, member 2 | #2 (m > flut > f) |
Cellular lipid metabolic process | Sgpp1 | Sphingosine-1-phosphate phosphatase 1 | #2 (m > flut > f) |
Cellular lipid metabolic process | Pbx1 | Pre b-cell leukemia transcription factor 1 | #5 (m > f > flut) |
Cellular lipid metabolic process | Hsd17b12 | Hydroxysteroid (17-beta) dehydrogenase 12 | #2 (m > flut > f) |
Cellular lipid metabolic process | Hadhb | Hydroxyacyl-coenzyme A dehydrogenase/3-ketoacyl-coenzyme A thiolase/enoyl-coenzyme A hydratase (trifunctional protein), beta subunit | #2 (m > flut > f) |
Cellular lipid metabolic process | Ggtla1 | Gamma-glutamyltransferase-like activity 1 | #3 (flut > f > m) |
Respiratory gaseous exchange | Pbx3 | Pre b-cell leukemia transcription factor 3 | #2 (m > flut > f) |
Respiratory tube development | Nfib | Nuclear factor i/b | #2 (m > flut > f) |
Respiratory tube development | Foxp1 | Forkhead box P1 | #5 (m > f > flut) |
Embryonic development | Kif1b | Kinesin family member 1b | #2 (m > flut > f) |
Embryonic development | Ext1 | Exostoses (multiple) 1 | #2 (m > flut > f) |
GESTATIONAL DAY 18 | |||
Lipid binding | Rock1 | Rho-associated coiled-coil forming kinase 1 | #5 (m > f > flut) |
Lipid binding | Nr5a2 | Nuclear receptor subfamily 5, group a, member 2 | #5 (m > f > flut) |
Steroid hormone receptor activity | Nr5a2 | Nuclear receptor subfamily 5, group a, member 2 | #5 (m > f > flut) |
Cellular lipid metabolic process | Pip5k3 | Phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III | #4 (f > flut > m) |
Cellular lipid metabolic process | Pbx1 | Pre b-cell leukemia transcription factor 1 | #4 (f > flut > m) |
Cellular lipid metabolic process | Nr5a2 | Nuclear receptor subfamily 5, group a, member 2 | #5 (m > f > flut) |
Cellular lipid metabolic process | Idi1 | Isopentenyl-diphosphate delta isomerase | #2 (m > flut > f) |
Cellular lipid metabolic process | Elovl6 | Elovl family member 6, elongation of long chain fatty acids (yeast) | #2 (m > flut > f) |
Cellular lipid metabolic process | Dhcr24 | 24-dehydrocholesterol reductase | #2 (m > flut > f) |
Cellular lipid metabolic process | Crls1 | Cardiolipin synthase 1 | #5 (m > f > flut) |
Lipid transport | Osbpl9 | Oxysterol binding protein-like 9 | #4 (f > flut > m) |
Respiratory gaseous exchange | Fut8 | Fucosyltransferase 8 | #4 (f > flut > m) |
Respiratory tube development | Gli1 | Gli-kruppel family member gli1 | #2 (m > flut > f) |