Figure 1

Hierarchical clustering of MMP and related gene expression during gestation. The black cells indicate down-regulation, and the white cells indicate up-regulation. Gray cells indicate no change in expression. A: endometrium, B: fetal tissues. Two animals were used on each day, and the array was done twice and the data shown represent the mean value. The data show a representative day as in Table 1. CAR: caruncule, ICAR: intercaruncle, ICOT: intercotyledon, COT: cotyledon. Microarray spots cDNA were created using the following genetic information: bovine MMP-1 (AF134714), bovine MMP-2 (AB043994), bovine MMP-3 (AF135232), bovine MMP-9 (X78324), human EMMPRIN (L10240), human MMP-1 (NM_002421), human MMP-2 (J03210), human MMP-3 (NM_002422), human MMP-9 (NM_004994), human MMP-13 (NM_002427), human MT1-MMP (NM_004995), human TIMP-1 (NM_004995), human TIMP-2 (J05593), human TIMP-3 (U14394), and human ADAMTS1 (AF207664).