Figure 1From: Ubp43 gene expression is required for normal Isg15 expression and fetal developmentIllustration of fetal development and Ubp43 genotype on day 17.5 of pregnancy (A) and description of how implantation sites were collected (B). A litter from a day 17.5 pregnant mouse shows that all Ubp43 null offspring were dead. Genotype ratio was 2:2:1 (wt:het:null) on day 17.5. On day 12.5, 75% of Ubp43 null mice were dead with a genotype ratio of 2:5:1. There also was a significant loss of +/- fetuses between 12.5 and 17.5 suggesting that Ubp43 gene dosage may also be involved. Panel B shows a cross-sectional representation of a mouse uterus illustrating the various tissues collected for protein and RNA analysis. Anti-mesometrial (AM) represents uterine tissue surrounding the fetal compartment. Fetal chorioallantoic placenta (CP) represents fetal-derived placental tissue. Mesometrial decidua (MM) represents uterine tissue in direct contact with fetal-derived placenta.Back to article page