Table 1 Various interspecies biological effects of relaxins relevant to known physiological actions.
From: Biology of primate relaxin: A paracrine signal in early pregnancy?
Relaxin Species a | Test species/system | Biological effect | Reference |
|---|---|---|---|
Human | Adult NHP | ↑ Prolactin and growth hormone secretion | [186] |
|  | Neonatal NHP uterine cells | ↑ cAMP production | [187] |
|  | Prepubertal pig | ↑ E-cadherin expression and uterine epithelial cell growth | [18] |
|  | Non-pregnant rat myometrium | ↓ Vassopressin induced contraction | [189] |
|  | Rat uterine artery | ↑ Nitric oxide production ↓ Phenylepherine induced contraction | [190] |
|  | Rat kidney | ↑ Glomerular filtration rate ↓ Renal vascular resistance | [191] |
|  | Mouse endometrial stromal cells | ↑ Protein synthesis ↑ Laminin production | [192] |
Marmoset | Human stromal cells, THP-1 monocytes | ↑ cAMP production | [21] |
Porcine | Rat | ↑ Uterine/body weight ratio | [193] |
|  | Mouse | ↑ interpubic ligament length | [194] |
Guinea Pig | Adult NHP endometrium | ↑ Thickness ↑ Vascularization | [141] |
Wallaby | Human THP-1 monocytes | ↑ cAMP production | [5] |