A new ovarian response prediction index (ORPI): implications for individualised controlled ovarian stimulation

Oliveira, Joao Batista A; Baruffi, Ricardo LR; Petersen, Claudia G; Mauri, Ana L; Nascimento, Adriana M; Vagnini, Laura; Ricci, Juliana; Cavagna, Mario; Franco, Jose G

doi:10.1186/1477-7827-10-94

Reproductive Biology and Endocrinology

Table 2 Correlation between predictors of the ovarian response (age, AMH, AFC and ORPI) and the total number of oocytes collected, total number of MII oocytes collected and the number of follicles ≥10 mm, ≥16 mm and ≥18 mm at the time of hCG administration

From: A new ovarian response prediction index (ORPI): implications for individualised controlled ovarian stimulation

Ovarian response markers	Variable Analyzed
	Total oocytes collected
	General population			GnRH agonist group			GnRH antagonist group
	r	95% CI	P	r	95% CI	P	r	95% CI	P
Age	−0.49	−0.63 to −0.32	<0.0001	−0.44	−0.62 to −0.20	0.0004	−0.57	−0.75 to −0.31	<0.0001
AMH	0.72	0.60 to 0.80	<0.0001	0.74	0.60 to 0.84	<0.0001	0.70	0.50 to 0.83	<0.0001
AFC	0.72	0.61 to 0.81	<0.0001	0.67	0.50 to 0.79	<0.0001	0.80	0.66 to 0.89	<0.0001
ORPI	0.78	0.68 to 0.84	<0.0001	0.78	0.66 to 0.87	<0.0001	0.81	0.65 to 0.89	<0.0001
	MII oocytes
	General population			GnRH agonist group			GnRH antagonist group
	r	95% CI	P	r	95% CI	P	r	95% CI	P
Age	−0.51	−0.64 to −0.34	<0.0001	−0.47	−0.65 to −0.24	0.0001	−0.58	−0.75 to −0.32	<0.0001
AMH	0.64	0.50 to 0.74	<0.0001	0.69	0.52 to 0.80	<0.0001	0.61	0.37 to 0.78	<0.0001
AFC	0.64	0.50 to 0.74	<0.0001	0.59	0.40 to 0.74	<0.0001	0.69	0.51 to 0.84	<0.0001
ORPI	0.70	0.57 to 0.78	<0.0001	0.74	0.59 to 0.83	<0.0001	0.70	0.48 to 0.83	<0.0001
	Follicles ≥10 mm
	General population			GnRH agonist group			GnRH antagonist group
	r	95% CI	P	r	95% CI	P	r	95% CI	P
Age	−0.50	−0.64 to −0.33	<0.0001	−0.44	−0.62 to −0.20	0.0005	−0.60	−0.77 to −0.35	<0.0001
AMH	0.77	0.67 to 0.84	<0.0001	0.80	0.68 to 0.88	<0.0001	0.77	0.61 to 0.88	<0.0001
AFC	0.76	0.65 to 0.83	<0.0001	0.76	0.62 to 0.85	<0.0001	0.79	0.63 to 0.88	<0.0001
ORPI	0.82	0.74 to 0.87	<0.0001	0.86	0.76 to 0.91	<0.0001	0.81	0.72 to 0.91	<0.0001
	Follicles ≥16 mm
	General population			GnRH agonist group			GnRH antagonist group
	r	95% CI	P	r	95% CI	P	r	95% CI	P
Age	−0.51	−0.65 to −0.35	<0.0001	−0.46	−0.64 to −0.23	0.0002	−0.62	−0.78 to −0.38	<0.0001
AMH	0.60	0.45 to 0.71	<0.0001	0.65	0.47 to 0.78	<0.0001	0.58	0.33 to 0.76	<0.0001
AFC	0.61	0.46 to 0.72	<0.0001	0.64	0.45 to 0.77	<0.0001	0.61	0.42 to 0.80	<0.0001
ORPI	0.67	0.53 to 0.76	<0.0001	0.72	0.56 to 0.82	<0.0001	0.67	0.45 to 0.81	<0.0001
	Follicles ≥18 mm
	General population			GnRH agonist group			GnRH antagonist group
	r	95% CI	P	r	95% CI	P	r	95% CI	P
Age	−0.44	−0.59 to −0.26	<0.0001	−0.35	−0.56 to −0.10	0.0053	−0.66	−0.81 to −0.44	<0.0001
AMH	0.50	0.33 to 0.63	<0.0001	0.50	0.31 to 0.69	<0.0001	0.56	0.30 to 0.74	0.0001
AFC	0.52	0.35 to 0.65	<0.0001	0.52	0.32 to 0.70	<0.0001	0.62	0.38 to 0.78	<0.0001
ORPI	0.56	0.40 to 0.68	<0.0001	0.56	0.37 to 0.72	<0.0001	0.65	0.42 to 0.80	<0.0001

AMH: anti-Mullerian hormone; ORPI: ovarian response prediction index; AFC: antral follicle count;
CI: confidence interval.

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ISSN: 1477-7827

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