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Table 2 Effect of progesterone, NOMAC, and MPA on the pituitary-adrenal axis in OVX rats

From: Preclinical pharmacological profile of nomegestrol acetate, a synthetic 19-nor-progesterone derivative

Treatment

Dose (mg/rat/day)

Rats (n)

Adrenal weight (mg)

Control (No OVX)

–

16

46.59 ± 1.51*

Control (OVX)

–

28

53.32 ± 1.63

Progesterone (OVX)

10

10

39.98 ± 2.15*

NOMAC (OVX)

0.3

10

58.38 ± 3.53

1

19

60.28 ± 1.89*

3

9

59.43 ± 2.03*

MPA (OVX)

0.1

8

47.28 ± 2.66*

0.3

10

37.35 ± 1.77*

1

8

27.58 ± 1.15*

3

8

20.86 ± 1.14*

  1. Adrenal weight is shown as the mean ± the standard error of the mean.
  2. ANOVA, analysis of variance; MPA, medroxyprogesterone acetate; NOMAC, nomegestrol acetate; OVX, ovariectomized.
  3. * P<0.05 vs OVX control (ANOVA).
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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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