Study type | No. Down’s | A | B | C | Additive effect on A’ |
---|
PAPP-A hCGbeta | PAPP-A sLHCGR | hCGbeta sLHCGR |
---|
PS 350 + 13
| N = 13 | | | | |
| DR% | 46.1 | 84.6 | 53.84 | 38.46 |
| FP% | 1.7 | 4.6 | 6 | 4.6 |
RS 120 + 30
| N = 30 | | | | |
| DR% | 56.6 | 46.7 | 50 | 13.3 |
| FP% | 0.83 | 4.16 | 13.3 | 4.16 |
Total 470 + 43
| N = 43 | | | | |
| DR% | 53.5 | 58.13 | 51.1 | 20.9 |
| FP% | 1.5 | 4.46 | 7.9 | 4.46 |
- The cut-off values used for PAPP-A, hCGbeta and hCG-sLHCGR were ≤0.5 MoM, ≥2.0 MoM and ≤5.0 plus ≥170 pmol/mL, respectively. Additive Effect on A (PAPP-A and hCGbeta measurement) shows the percentage of additional T21 pregnancies detected by the hCG-sLHCGR and PAPP-A combination which had not been detected by PAPP-A and hCGbeta measurements.