https://rbej.biomedcentral.com/articles/10.1186/s12958-016-0172-y
https://rbej.biomedcentral.com/articles/10.1186/s12958-016-0175-8
https://rbej.biomedcentral.com/articles/10.1186/s12958-016-0169-6
https://rbej.biomedcentral.com/articles/10.1186/s12958-016-0173-x