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  1. Evidence referring to the trade-offs between the benefits and risks of single embryo transfer (SET) versus double embryo transfer (DET) following assisted reproduction technology are insufficient, especially f...

    Authors: Shujuan Ma, Yangqin Peng, Liang Hu, Xiaojuan Wang, Yiquan Xiong, Yi Tang, Jing Tan and Fei Gong

    Citation: Reproductive Biology and Endocrinology 2022 20:20

    Content type: Review

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  2. Nitric oxide and GnRH are biological factors that participate in the regulation of reproductive functions. To our knowledge, there are no studies that link NO and GnRH in the sympathetic ganglia. Thus, the aim...

    Authors: Sandra Vallcaneras, Laura Morales, María Belén Delsouc, Darío Ramirez, Verónica Filippa, Marina Fernández, Carlos M. Telleria and Marilina Casais

    Citation: Reproductive Biology and Endocrinology 2022 20:19

    Content type: Research

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  3. In vitro maturation (IVM) of oocytes is a laboratory method that allows the maturation of immature (GV) oocytes retrieved from patients enrolled in the in vitro fertilization (IVF) programme. However, this met...

    Authors: Jure Bedenk, Tadeja Režen, Taja Železnik Ramuta, Nina Jančar, Eda Vrtačnik Bokal, Ksenija Geršak and Irma Virant Klun

    Citation: Reproductive Biology and Endocrinology 2022 20:18

    Content type: Research

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  4. Overwhelming evidences suggest oxidative stress is a major cause of sperm dysfunction and male infertility. Zinc is an important non-enzymatic antioxidant with a wide range of biological functions and plays a ...

    Authors: Xinye Zhu, Chengxuan Yu, Wangshu Wu, Lei Shi, Chenyi Jiang, Li Wang, Zhide Ding and Yue Liu

    Citation: Reproductive Biology and Endocrinology 2022 20:17

    Content type: Research

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  5. Sleep is vital to human bodily function. Growing evidence indicates that sleep deprivation, disruption, dysrhythmia, and disorders are associated with impaired reproductive function and poor clinical outcomes ...

    Authors: Gabriela Beroukhim, Ecem Esencan and David B. Seifer

    Citation: Reproductive Biology and Endocrinology 2022 20:16

    Content type: Review

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  6. Ovarian stimulation during medically assisted reproduction treatment should be individualized to optimize outcomes and reduce complications. This study assessed whether use of the recombinant human follicle-st...

    Authors: Bum Chae Choi, Canquan Zhou, Hong Ye, Yun Sun, Ying Zhong, Fei Gong, Ivan Sini, Nadezda Abramova, Salvatore Longobardi, Miranda Hickey and Thomas D’Hooghe

    Citation: Reproductive Biology and Endocrinology 2022 20:15

    Content type: Research

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  7. During pregnancy, maternal metabolism undergoes substantial changes to support the developing fetus. Such changes are finely regulated by different mechanisms carried out by effectors such as microRNAs (miRNAs...

    Authors: Cécilia Légaré, Andrée-Anne Clément, Véronique Desgagné, Kathrine Thibeault, Frédérique White, Simon-Pierre Guay, Benoit J. Arsenault, Michelle S. Scott, Pierre-Étienne Jacques, Patrice Perron, Renée Guérin, Marie-France Hivert and Luigi Bouchard

    Citation: Reproductive Biology and Endocrinology 2022 20:14

    Content type: Research

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  8. Adenomyosis is a chronic gynecological disease characterized by invasion of the uterine endometrium into the muscle layer. In assisted reproductive technology (ART), gonadotropin-releasing hormone agonist (GnR...

    Authors: Jiao Tian, Nannan Kang, Junxia Wang, Haixiang Sun, Guijun Yan, Chenyang Huang and Jie Mei

    Citation: Reproductive Biology and Endocrinology 2022 20:13

    Content type: Research

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  9. As a common endocrinopathy of reproductive-aged women, polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, oligo-anovulation and polycystic ovarian morphology. It is linked with insulin resi...

    Authors: Daniel A. Dumesic, Vasantha Padmanabhan, Gregorio D. Chazenbalk and David H. Abbott

    Citation: Reproductive Biology and Endocrinology 2022 20:12

    Content type: Review

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  10. It is not known by which mechanism endometrial injury increases pregnancy rates. Leukaemia inhibitory factor (LIF) is a cytokine involved in wound healing and implantation. The aim of this study was to determi...

    Authors: Suat Suphan Ersahin and Aynur Ersahin

    Citation: Reproductive Biology and Endocrinology 2022 20:11

    Content type: Research

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  11. The utilization of oocyte cryopreservation (OC) has become popularized with increasing numbers of reproductive-aged patients desiring to maintain fertility for future family building. OC was initially used for...

    Authors: Zachary Walker, Andrea Lanes and Elizabeth Ginsburg

    Citation: Reproductive Biology and Endocrinology 2022 20:10

    Content type: Review

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  12. Intrauterine adhesion (IUA) is one of the leading causes of infertility and the main clinical challenge is the high recurrence rate. The key to solving this dilemma lies in elucidating the mechanisms of endome...

    Authors: Chengcheng Xu, Meng Bao, Xiaorong Fan, Jin Huang, Changhong Zhu and Wei Xia

    Citation: Reproductive Biology and Endocrinology 2022 20:9

    Content type: Research

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  13. Preeclampsia is characterized by decreased trophoblastic angiogenesis leading to abnormal invasion of spiral arteries, shallow implantation and resulting in compromised placentation with poor uteroplacental pe...

    Authors: David B. Seifer, Geralyn Lambert-Messerlian, Glenn E. Palomaki, Robert M. Silver, Corette Parker, Carol J. Rowland Hogue, Barbara J. Stoll, George R. Saade, Robert L. Goldenberg, Donald J. Dudley, Radek Bukowski, Halit Pinar and Uma M. Reddy

    Citation: Reproductive Biology and Endocrinology 2022 20:8

    Content type: Research

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  14. The primary objective of the present study of women participating in an ICSI program was to determine whether the morphologic quality of oocytes was related to the polycystic ovary syndrome (PCOS) phenotype.

    Authors: Audrey Uk, Christine Decanter, Camille Grysole, Laura Keller, Hélène Béhal, Mauro Silva, Didier Dewailly, Geoffroy Robin and Anne-Laure Barbotin

    Citation: Reproductive Biology and Endocrinology 2022 20:7

    Content type: Research

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  15. Moving from the correlation between insulin-resistance and PCOS, metformin has been administered in some PCOS women improving ovulatory and metabolic functions and decreasing androgen levels. Inconsistency and...

    Authors: Emanuele Garzia, Valentina Galiano, Giovanni Marfia, Stefania Navone, Enzo Grossi and Anna Maria Marconi

    Citation: Reproductive Biology and Endocrinology 2022 20:6

    Content type: Research

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  16. Potassium channels are important for the structure and function of the spermatozoa. As a potassium transporter, the mSlo3 is essential for male fertility as Slo3 knockout male mice were infertile with the series ...

    Authors: Mingrong Lv, Chunyu Liu, Chunjie Ma, Hui Yu, Zhongmei Shao, Yang Gao, Yiyuan Liu, Huan Wu, Dongdong Tang, Qing Tan, Junqiang Zhang, Kuokuo Li, Chuan Xu, Hao Geng, Jingjing Zhang, Hang Li…

    Citation: Reproductive Biology and Endocrinology 2022 20:5

    Content type: Research

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  17. Insulin resistance (IR) contributes to ovarian dysfunctions in polycystic ovarian syndrome (PCOS) patients. Serum amyloid A1 (SAA1) is an acute phase protein produced primarily by the liver in response to infl...

    Authors: Qinling Zhu, Yue Yao, Lizhen Xu, Hasiximuke Wu, Wangsheng Wang, Yaqiong He, Yuan Wang, Yao Lu, Jia Qi, Ying Ding, Xinyu Li, Jiaan Huang, Hanting Zhao, Yanzhi Du, Kang Sun and Yun Sun

    Citation: Reproductive Biology and Endocrinology 2022 20:4

    Content type: Research

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  18. Successful implantation is dependent on coordination between maternal endometrium and embryo, and the role of EVs in the required cross-talk cell-to-cell has been recently established. In this regard, it has b...

    Authors: Marina Segura-Benítez, María Cristina Carbajo-García, Ana Corachán, Amparo Faus, Antonio Pellicer and Hortensia Ferrero

    Citation: Reproductive Biology and Endocrinology 2022 20:3

    Content type: Research

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  19. Women with uterine adenomyosis seeking assisted reproduction have been associated with compromised endometrial receptivity to embryo implantation. To understand the mechanisms involved in this process, we aime...

    Authors: Erika Prašnikar, Tanja Kunej, Mario Gorenjak, Uroš Potočnik, Borut Kovačič and Jure Knez

    Citation: Reproductive Biology and Endocrinology 2022 20:2

    Content type: Research

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  20. Several clinical studies showed that statins were potential to treat polycystic ovary syndrome (PCOS). Through comprehensive search PubMed, EMBASE, the Web of Science, BIOSIS, the ClinialTrails.gov, and the Co...

    Authors: Jianguo Chen, Chaoran Huang, Tongtong Zhang, Wuqing Gong, Xiaofeng Deng, Hua Liu, Jinbo Liu and Yuanbiao Guo

    Citation: Reproductive Biology and Endocrinology 2021 19:189

    Content type: Research

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  21. To investigate the role of adenosine monophosphate (AMP)-activated protein kinase (AMPK) on the production of interleukin (IL)-8, monocyte chemoattractant protein (MCP)-1, prostaglandin E2 and F2α induced by I...

    Authors: Yasushi Kawano, Hatsumi Sato, Kaori Goto, Masakazu Nishida and Kaei Nasu

    Citation: Reproductive Biology and Endocrinology 2021 19:188

    Content type: Research

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  22. Recurrent implantation failure (RIF) is a major limitation of assisted reproductive technology, which is associated with impaired endometrial receptivity. Although N6-methyladenosine (m6A) has been demonstrated t...

    Authors: Pingping Xue, Wenbo Zhou, Wenqiang Fan, Jianya Jiang, Chengcai Kong, Wei Zhou, Jianmei Zhou, Xiaoyang Huang, Haiyan Yang, Qian Han, Bin Zhang, Lingyun Xu, Bin Yu and Li Chen

    Citation: Reproductive Biology and Endocrinology 2021 19:187

    Content type: Research

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  23. The goal of this study was to investigate which factors, excluding embryo aneuploidies, are associated with miscarriage in patients who have undergone a single euploid blastocyst transfer.

    Authors: María del Carmen Nogales, María Cruz, Silvia de Frutos, Eva María Martínez, María Gaytán, Marta Ariza, Fernando Bronet and Juan A. Garcia-Velasco

    Citation: Reproductive Biology and Endocrinology 2021 19:186

    Content type: Research

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  24. For the association between time-lapse technology (TLT) and embryo ploidy status, there has not yet been fully understood. TLT has the characteristics of large amount of data and non-invasiveness. If we want t...

    Authors: Bo Huang, Wei Tan, Zhou Li and Lei Jin

    Citation: Reproductive Biology and Endocrinology 2021 19:185

    Content type: Research

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  25. Polycystic ovary syndrome (PCOS) is a common endocrine disorder with the disorders of estrogen(E2) and progesterone(P) secretion. The purpose of this study was to evaluate the association between the progester...

    Authors: Yiqing Yang, Bowen Liu, Gengxiang Wu and Jing Yang

    Citation: Reproductive Biology and Endocrinology 2021 19:184

    Content type: Research

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  26. To improve the developmental competence of in vitro cultured oocytes, extensive literature focused on maturation rate improvement with different additives in culture medium, while studies investigating the mat...

    Authors: Qiyu Yang, Lixia Zhu, Meng Wang, Bo Huang, Zhou Li, Juan Hu, Qingsong Xi, Jing Liu and Lei Jin

    Citation: Reproductive Biology and Endocrinology 2021 19:183

    Content type: Research

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  27. Luteinizing hormone (LH) and human chorionic gonadotropin (hCG) activate distinct intracellular signaling cascades. However, due to their similar structure and common receptor, they are used interchangeably du...

    Authors: M. Kirshenbaum, O. Gil, J. Haas, R. Nahum, E. Zilberberg, O. Lebovitz and R. Orvieto

    Citation: Reproductive Biology and Endocrinology 2021 19:182

    Content type: Research

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  28. The quality of the early embryo is vital to embryonic development and implantation. As a highly conserved serine/threonine kinase, p21-activated kinase 2 (Pak2) participates in diverse biologic processes, espe...

    Authors: Juan Zeng, Nengqing Liu, Yinghong Yang, Yi Cheng, Yuanshuai Li, Xiaoxia Guo, Qian Luo, Lifen Zhu, Hongmei Guan, Bing Song and Xiaofang Sun

    Citation: Reproductive Biology and Endocrinology 2021 19:181

    Content type: Research

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  29. MicroRNAs (miRNAs) are small, non-coding RNAs that are dysregulated in many diseases and can act as biomarkers. Although well-studied in cancer, the role of miRNAs in embryo implantation is poorly understood. ...

    Authors: Hong Zeng, Yu Fu, Lang Shen and Song Quan

    Citation: Reproductive Biology and Endocrinology 2021 19:180

    Content type: Research

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  30. Ovarian endometrioma is a common gynecological disease that is often treated with surgery or hormonal treatment. Ovarian cystectomy, a surgical procedure for ovarian endometrioma, can result in impaired ovaria...

    Authors: Ayako Muraoka, Satoko Osuka, Atsushi Yabuki, Bayasula, Masato Yoshihara, Hideaki Tanaka, Reina Sonehara, Natsuki Miyake, Mayuko Murakami, Sayako Yoshita, Natsuki Nakanishi, Tomoko Nakamura, Maki Goto, Akira Iwase and Hiroaki Kajiyama

    Citation: Reproductive Biology and Endocrinology 2021 19:179

    Content type: Research

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  31. Ovarian cancer is the leading cause of death in patients with gynecologic cancer, and circular RNAs (circRNAs) are involved in cancer progression. However, there are limited studies on the roles of circRNAs in...

    Authors: Yuping Du, Xin Liu, Song Zhang, Shuo Chen, Xue Guan, Qianhui Li, Xi Chen and Yang Zhao

    Citation: Reproductive Biology and Endocrinology 2021 19:176

    Content type: Research

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  32. Immune dysfunction is one of the mechanisms to promote polycystic ovary syndrome (PCOS). Various immune cells have been reported to be involved in the development of PCOS. Meanwhile, the disturbance of metabol...

    Authors: Mengting Zhu, Yuping Xu, Caihua Li, Zhimin Lu, Kaihuan Bi, Kangxia Wang, Peipei Guo, Huanhuan Jiang and Yunxia Cao

    Citation: Reproductive Biology and Endocrinology 2021 19:175

    Content type: Research

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  33. Assisted reproductive technology (ART) insurance mandates promote more selective utilization of ART clinic resources including intracytoplasmic sperm injection (ICSI). Our objective was to examine whether ICSI...

    Authors: Pavel Zagadailov, Kyung S. Cho and David B. Seifer

    Citation: Reproductive Biology and Endocrinology 2021 19:174

    Content type: Research

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  34. Bone morphogenetic protein 2 (BMP2), growth differentiation factor 8 (GDF8) and their functional receptors are expressed in human ovarian follicles, and these two intrafollicular factors play essential roles i...

    Authors: Xiaoyan Luo, Hsun-Ming Chang, Yuyin Yi, Yingpu Sun and Peter C. K. Leung

    Citation: Reproductive Biology and Endocrinology 2021 19:173

    Content type: Research

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  35. Information regarding the influence of cytoplasmic events during fertilisation on the clinical outcome remains limited. The cytoplasmic halo is one of these events. A previous study that used time-lapse techno...

    Authors: Kenji Ezoe, Tetsuya Miki, Tadashi Okimura, Kazuo Uchiyama, Akiko Yabuuchi, Tamotsu Kobayashi and Keiichi Kato

    Citation: Reproductive Biology and Endocrinology 2021 19:172

    Content type: Research

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  36. With the increased use of assisted reproductive technology (ART), assessing the potential health risks of children conceived on ART important to public health. Most research in this area has focused on the eff...

    Authors: Xin Xu, Han Wu, Yuehong Bian, Linlin Cui, Yuanyuan Man, Zhao Wang, Xin Zhang, Changming Zhang and Ling Geng

    Citation: Reproductive Biology and Endocrinology 2021 19:171

    Content type: Research

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  37. Polycystic ovary syndrome (PCOS) is an endocrine-related follicular developmental disorder that affects 50 %-70 % of reproductive-aged women diagnosed with ovulation-related infertility. Abnormal proliferation...

    Authors: Yi-xuan Wu, Yan-shan Lin, Si-chen Li, Xi Yao, Mingwei Cheng, Lin Zhu and Hai-ying Liu

    Citation: Reproductive Biology and Endocrinology 2021 19:170

    Content type: Research

    Published on:

  38. Citation: Reproductive Biology and Endocrinology 2021 19:169

    Content type: Correction

    Published on:

    The original article was published in Reproductive Biology and Endocrinology 2021 19:137

  39. Diabetes mellitus (DM), a chronic metabolic disease, severely impairs male reproductive function. However, the underpinning mechanisms are still incompletely defined, and there are no effective strategies or m...

    Authors: Weiguo He, Huiqing Liu, Linlin Hu, Yaohui Wang, Lane Huang, Aihong Liang, Xuan Wang, Qing Zhang, Yi Chen, Yi Cao, Suyun Li, Junli Wang and Xiaocan Lei

    Citation: Reproductive Biology and Endocrinology 2021 19:168

    Content type: Research

    Published on:

  40. Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disease in women at childbearing age. Several circular RNAs (circRNAs) have been demonstrated to be involved in PCOS. In this study, we aime...

    Authors: Lishuang Xu, Fang Xiong, Yinyang Bai, Juxia Xiao, Yun Zhang, Jie Chen and Qiuping Li

    Citation: Reproductive Biology and Endocrinology 2021 19:167

    Content type: Research

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  41. Maternal metabolic disorders are linked to reduced metabolic health and oocyte quality. Obese women are advised to lose weight before conception to increase pregnancy chances. However, as human studies show no...

    Authors: Anouk Smits, Waleed F. A. Marei, Diane De Neubourg and Jo L. M. R. Leroy

    Citation: Reproductive Biology and Endocrinology 2021 19:166

    Content type: Research

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  42. Progesterone supplementation is widely performed in women with threatened miscarriage or a history of recurrent miscarriage; however, the effects of early progesterone supplementation on pregnancy-related comp...

    Authors: Hanglin Wu, Songying Zhang, Xiaona Lin, Jing He, Shasha Wang and Ping Zhou

    Citation: Reproductive Biology and Endocrinology 2021 19:165

    Content type: Review

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  43. Pregnancies with > 1 corpus luteum (CL) display a hyperdynamic circulation and an increased risk of small-for-gestational age deliveries. Among the factors released by the CL is prorenin, the inactive precurso...

    Authors: Rosalieke E. Wiegel, Maud J. H. Karsten, Igna F. Reijnders, Lenie van Rossem, Sten P. Willemsen, Annemarie G. M. G. J. Mulders, Anton H. J. Koning, Eric A. P. Steegers, A. H. Jan Danser and Régine P. M. Steegers-Theunissen

    Citation: Reproductive Biology and Endocrinology 2021 19:164

    Content type: Research

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  44. The application of artificial oocyte activation (AOA) after intracytoplasmic sperm injection (ICSI) is successful in mitigating fertilization failure problems in assisted reproductive technology (ART). Neverth...

    Authors: Mingru Yin, Weina Yu, Wenzhi Li, Qianqian Zhu, Hui Long, Pengcheng Kong and Qifeng Lyu

    Citation: Reproductive Biology and Endocrinology 2021 19:163

    Content type: Research

    Published on:

  45. Endometriosis, the presence of active endometrial tissue outside the lining membrane of the uterine cavity, is a common disease in women of childbearing age. The ectopic endometrium has some characteristics of...

    Authors: Liya Shi, Xue Xue, Hui Tian, Hongjuan Ye, Hui Wang, Rongxiang Wang, Yu Liu, Caixia Zhang, Qiuju Chen and Lihua Sun

    Citation: Reproductive Biology and Endocrinology 2021 19:161

    Content type: Research

    Published on:

  46. Infertility associated with endometriosis can be explained by several non-exclusive mechanisms. The oocyte plays a crucial role in determining embryonic competence and this is particularly relevant for in vitr...

    Authors: Camille Robin, Audrey Uk, Christine Decanter, Hélène Behal, Pierre Collinet, Chrystèle Rubod, Anne-Laure Barbotin and Geoffroy Robin

    Citation: Reproductive Biology and Endocrinology 2021 19:160

    Content type: Research

    Published on:

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