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  1. Content type: Research

    Polycystic ovary syndrome (PCOS) is one of the most common endocrine metabolic disorders characterized by hyperandrogenism, polycystic ovaries and ovulatory dysfunction. Several studies have reported that the ...

    Authors: Tingting He, Yifei Sun, Yingchun Zhang, Shigang Zhao, Yanjun Zheng, Guimin Hao and Yuhua Shi

    Citation: Reproductive Biology and Endocrinology 2019 17:68

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  2. Content type: Review

    Polycystic ovary syndrome (PCOS) is a prevalent hormonal disorder of premenopausal women worldwide and is characterized by reproductive, endocrine, and metabolic abnormalities. The clinical manifestations of P...

    Authors: Jingshun Zhang, Yigang Bao, Xu Zhou and Lianwen Zheng

    Citation: Reproductive Biology and Endocrinology 2019 17:67

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  3. Content type: Research

    Sperm morphology mainly refers to the shape of the head, the length of the flagellar segments, including the midpiece, principal piece and end piece, and the size of the accessory structures, including axoneme...

    Authors: Ni-Hao Gu, Wen-Long Zhao, Gui-Shuan Wang and Fei Sun

    Citation: Reproductive Biology and Endocrinology 2019 17:66

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  4. Content type: Review

    Kisspeptin and its G protein-coupled receptor KISS1R play key roles in mammalian reproduction due to their involvement in the onset of puberty and control of the hypothalamic-pituitary-gonadal axis. However, r...

    Authors: Yubin Cao, Zeping Li, Wenyu Jiang, Yan Ling and Haibin Kuang

    Citation: Reproductive Biology and Endocrinology 2019 17:65

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  5. Content type: Research

    Fluorochloridone (FLC) is a widely used herbicide, and its target organs are testes and epididymides. The Globally Harmonized System of Classification and Labelling of Chemicals classified FLC as Level 2-possi...

    Authors: Rui Li, Su Zhou, Hongyan Zhu, Zhichao Zhang, Jing Fang, Ping Liu, Yu Wang, Xiuli Chang, Yubin Zhang, Liming Tang and Zhijun Zhou

    Citation: Reproductive Biology and Endocrinology 2019 17:64

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  6. Content type: Research

    Aberrant DNA damage of germ cells, which impairs spermatogenesis and lowers fertility, is an important factor contributing to male infertility. MicroRNAs (miRNAs) play a significant role in the expression and ...

    Authors: Qi Che, Wei Wang, Peng Duan, Fang Fang, Chunyan Liu, Ting Zhou, Honggang Li, Chengling Xiong and Kai Zhao

    Citation: Reproductive Biology and Endocrinology 2019 17:63

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  7. Content type: Research

    To evaluate Subendometrial and Uterine artery resistance and pulsatility index continuous analysis as a predictor of Endometrial receptivity in Assisted Reproductive Technology (ART) Cycles.

    Authors: R. Silva Martins, A. Helio Oliani, D. Vaz Oliani and J. Martinez de Oliveira

    Citation: Reproductive Biology and Endocrinology 2019 17:62

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  8. Content type: Research

    Increasing evidence demonstrate that cadmium (Cd) has adverse effects on the mammalian reproductive system. However, the mechanisms underlying the effects of Cd on ovarian function and the strategies to revers...

    Authors: Qingling Yang, Jing Zhu, Xiaoyan Luo, Fangyuan Li, Luping Cong, Yujiao Wang and Yingpu Sun

    Citation: Reproductive Biology and Endocrinology 2019 17:61

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  9. Content type: Research

    Nerve growth factor (β-NGF) from llama seminal plasma has been described as a potent ovulatory and luteotrophic molecule after intramuscular or intrauterine infusion in llamas and alpacas. We tested the hypoth...

    Authors: Ximena P. Valderrama, Jose F. Goicochea, Mauricio E. Silva and Marcelo H. Ratto

    Citation: Reproductive Biology and Endocrinology 2019 17:60

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  10. Content type: Research

    Vitamin D plays critical role in the female reproductive system. It seems that vitamin D is associated with clinical pregnancy outcomes of assisted reproductive technologies (ART), but its role remains elusive...

    Authors: Xuemei Liu, Wei Zhang, Yanping Xu, Yongli Chu, Xinrong Wang, Qian Li, Zhi Ma, Zhenteng Liu and Yanling Wan

    Citation: Reproductive Biology and Endocrinology 2019 17:59

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  11. Content type: Research

    To determine the effects of age and the serum anti-Müllerian hormone (AMH) level on in vitro fertilization (IVF) outcomes, especially among young women with low serum AMH levels and older women with high AMH l...

    Authors: Bingqian Zhang, Yueru Meng, Xiao Jiang, Chao Liu, Huihui Zhang, Linlin Cui and Zi-Jiang Chen

    Citation: Reproductive Biology and Endocrinology 2019 17:58

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  12. Content type: Correction

    Following publication of the original article [1], the authors would like to apologize for an error in Fig. 5e, the correct graph is presented below and shows the significant increase in pituitary mRNA levels of

    Authors: Rüdiger W. Schulz, Geir Lasse Taranger, Jan Bogerd, Wouter Nijenhuis, Birgitta Norberg, Rune Male and Eva Andersson

    Citation: Reproductive Biology and Endocrinology 2019 17:57

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    The original article was published in Reproductive Biology and Endocrinology 2019 17:48

  13. Content type: Research

    To investigate the therapeutic effects of menstrual blood derived mesenchymal stem cells (MB-MSCs) combined with Bushen Tiaochong recipe (BSTCR) on epirubicin induced premature ovarian failure (POF) in mice.

    Authors: Fengyi Guo, Tian Xia, Yedan Zhang, Xiaotong Ma, Zhongrui Yan, Shaohua Hao, Yali Han, Ruihong Ma, Yuan Zhou and Xue Du

    Citation: Reproductive Biology and Endocrinology 2019 17:56

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  14. Content type: Research

    Cell-free mitochondrial DNA (cf-mtDNA) in body fluids has attracted much attention for the purpose of monitoring disease because of the clinical advantages. This study investigated whether the cf-mtDNA content...

    Authors: Yu Liu, Qiuzi Shen, Xue Zhao, Min Zou, Shumin Shao, Jiao Li, Xinling Ren and Ling Zhang

    Citation: Reproductive Biology and Endocrinology 2019 17:54

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  15. Content type: Research

    Bisphenol A is well known endocrine-disrupting chemical while Bisphenol S was considered a safe alternative. The present study aims to examine the comparative effects of xenobiotic bisphenol-A (BPA) and its su...

    Authors: Naham John, Humaira Rehman, Suhail Razak, Mehwish David, Waheed Ullah, Tayyaba Afsar, Ali Almajwal, Iftikhar Alam and Sarwat Jahan

    Citation: Reproductive Biology and Endocrinology 2019 17:53

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  16. Content type: Research

    Recurrent pregnancy loss (RPL) refers to two or more spontaneous abortions that occur consecutively with the same spouse. RPL severely affects human reproduction health, and causes extreme physical and mental ...

    Authors: Dena Xue, Yi Zhang, Yixin Wang, Jun Wang, Fengxiao An, Xiaowei Sun and Zhenhai Yu

    Citation: Reproductive Biology and Endocrinology 2019 17:52

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  17. Content type: Research

    In general, anti-Müllerian hormone (AMH) is positively associated with antral follicle count (AFC). However, there is often discordance between the AMH level and AFC in clinical practice. In cases of discordan...

    Authors: Yangyang Zhang, Yang Xu, Qing Xue, Jing Shang, Xiuli Yang, Xuemin Shan, Yanrong Kuai, Sheng Wang and Cheng Zeng

    Citation: Reproductive Biology and Endocrinology 2019 17:51

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  18. Content type: Research

    The placenta is a highly specialized temporary organ that is related to fetal development and pregnancy outcomes, and epidemiological data demonstrate an increased risk of placental abnormality after in vitro ...

    Authors: Liang Zhao, Xiuli Zheng, Jingfang Liu, Rong Zheng, Rui Yang, Ying Wang and Lifang Sun

    Citation: Reproductive Biology and Endocrinology 2019 17:50

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  19. Content type: Research

    Superovulation treatment had some adverse effects on maturity and development of oocytes. Can superovulation dose of gonadotropins (Gns) affect the transcriptome of granulosa cells and follicular fluid (FF) ho...

    Authors: Cui-Ling Lu, Zhi-Qiang Yan, Xue-Ling Song, Yang-Ying Xu, Xiao-Ying Zheng, Rong Li, Ping Liu, Huai-Liang Feng and Jie Qiao

    Citation: Reproductive Biology and Endocrinology 2019 17:49

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  20. Content type: Research

    Puberty in male Atlantic salmon in aquaculture can start as early as after the first winter in seawater, stunts growth and entails welfare problems due to the maturation-associated loss of osmoregulation capac...

    Authors: Rüdiger W. Schulz, Geir Lasse Taranger, Jan Bogerd, Wouter Nijenhuis, Birgitta Norberg, Rune Male and Eva Andersson

    Citation: Reproductive Biology and Endocrinology 2019 17:48

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    The Correction to this article has been published in Reproductive Biology and Endocrinology 2019 17:57

  21. Content type: Research

    Human follicular fluid is an intricate biological fluid contributing to the developing oocyte microenvironment. Accumulating evidence suggests that sex hormones present in follicular fluid (FF) may play an imp...

    Authors: Yvonne O’Brien, Mary Wingfield and Lynne C. O’Shea

    Citation: Reproductive Biology and Endocrinology 2019 17:47

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  22. Content type: Research

    Reproductive aging is a robust phenotype that occurs in all females and is characterized by a significant reduction in gamete quantity and quality, which can have negative consequences on both endocrine functi...

    Authors: Shweta S. Dipali, Christina R. Ferreira, Luhan T. Zhou, Michele T. Pritchard and Francesca E. Duncan

    Citation: Reproductive Biology and Endocrinology 2019 17:46

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  23. Content type: Research

    Polycystic ovary syndrome (PCOS) is a complex disorder associated with multiple metabolic disturbance, including defective glucose metabolism and insulin resistance. The altered metabolites caused by the relat...

    Authors: Zhengao Sun, Hsun-Ming Chang, Aijuan Wang, Jingyan Song, Xingxing Zhang, Jiayin Guo, Peter C. K. Leung and Fang Lian

    Citation: Reproductive Biology and Endocrinology 2019 17:45

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  24. Content type: Short communication

    Blastomere movement (BMov) occurs after the first cell division in human embryos. This movement has been suggested as a prognostic parameter for pregnancy outcome prediction following cleavage-stage embryo tra...

    Authors: Kazuki Ohata, Kenji Ezoe, Tetsuya Miki, Hirofumi Morita, Ryoma Tsuchiya, Shigeru Kaneko, Tadashi Okimura, Kazuo Uchiyama, Akiko Yabuuchi, Tamotsu Kobayashi, Markus Montag and Keiichi Kato

    Citation: Reproductive Biology and Endocrinology 2019 17:44

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  25. Content type: Research

    Almost all of the previous studies related with co-administration of letrozole in IVF cycles were performed in poor responders and letrozole may reduce the total gonadotropin dose required for ovarian stimulat...

    Authors: Xiaoyi Yang, Ge Lin, Guangxiu Lu and Fei Gong

    Citation: Reproductive Biology and Endocrinology 2019 17:43

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  26. Content type: Short communication

    Our previous studies showed that the miRNA clusters, miR-183-96-182 and miR-212-132, may be critical in promoting luteal cell survival and progesterone production in both bovine and humans. To further understa...

    Authors: Bushra T. Mohammed, Cristina L. Esteves and F. Xavier Donadeu

    Citation: Reproductive Biology and Endocrinology 2019 17:41

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  27. Content type: Research

    The maternal body forms a wireless communication system with the embryo through the blood circulation system. Obviously, direct sampling from early embryos is damaging. Therefore, we detected changes in the co...

    Authors: Miao Zhao, Tingting Liu and Guangchang Pang

    Citation: Reproductive Biology and Endocrinology 2019 17:40

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  28. Content type: Review

    Maternal nutrition during pregnancy has life-long consequences for offspring. However, the effects of maternal overnutrition and/ or obesity on fetal growth remain poorly understood, e.g., it is not clear why ...

    Authors: Julian K. Christians, Kendra I. Lennie, Lisa K. Wild and Raajan Garcha

    Citation: Reproductive Biology and Endocrinology 2019 17:39

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  29. Content type: Research

    Endometriosis is an estrogen dependent, inflammatory disorder occurring in 5–10% of reproductive-aged women. Women with endometriosis have a lower body mass index (BMI) and decreased body fat compared to those...

    Authors: Masoumeh Majidi Zolbin, Ramanaiah Mamillapalli, Sepide E. Nematian, Laura Goetz and Hugh S. Taylor

    Citation: Reproductive Biology and Endocrinology 2019 17:36

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  30. Content type: Research

    Matrix metalloproteinases (MMPs), especially the gelatinases MMP-2 and MMP-9, play a crucial role in the pathogenesis of endometriosis by enabling invasion. Doxycycline is a well-tolerated antibiotic and a pot...

    Authors: Eleftherios P. Samartzis, Daniel Fink, Manuel Stucki and Patrick Imesch

    Citation: Reproductive Biology and Endocrinology 2019 17:38

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  31. Content type: Research

    Ovarian hyperstimulation syndrome (OHSS) is a common and severe complication for patients undergoing IVF/ICSI-ET. Melatonin widely participates in the regulation of female reproductive endocrine activity. Howe...

    Authors: Yiran Li, Lanlan Fang, Yiping Yu, Hao Shi, Sijia Wang, Yanjie Guo and Yingpu Sun

    Citation: Reproductive Biology and Endocrinology 2019 17:37

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  32. Content type: Research

    Serum Antimüllerian hormone (AMH) has been shown to predict various in vitro fertilization (IVF) outcomes. AMH and progesterone (P) are products of granulosa cells of the ovary. Since overall granulosa cell nu...

    Authors: Shahryar K. Kavoussi, Shu-Hung Chen, Caitlin L. Hunn, Brady T. West, John David Wininger, Keikhosrow M. Kavoussi and Parviz K. Kavoussi

    Citation: Reproductive Biology and Endocrinology 2019 17:35

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  33. Content type: Research

    Women with Polycystic Ovary Syndrome (PCOS) present a heterogeneous reproductive and metabolic profile with an increased lifetime risk of Type 2 Diabetes (T2D). Early biomarkers of these metabolic disturbances...

    Authors: Pernille Bækgaard Udesen, Anja Elaine Sørensen, Mugdha V. Joglekar, Anandwardhan A. Hardikar, Marie Louise Muff Wissing, Anne-Lis Mikkelsen Englund and Louise Torp Dalgaard

    Citation: Reproductive Biology and Endocrinology 2019 17:34

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  34. Content type: Research

    The fibrinolytic system and its inhibitors play a number of roles, apart from their function in blood haemostasis and thrombosis, namely in ovarian folliculogenesis and in ovulation. Plasminogen is converted t...

    Authors: Genia F. Burchall, Dodie S. Pouniotis, Helena J. Teede, Sanjeeva Ranasinha, Kirsty A. Walters and Terrence J. Piva

    Citation: Reproductive Biology and Endocrinology 2019 17:33

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  35. Content type: Research

    A predominant difference between endometrial and normal cells is higher proliferation rate in the former cells which is benign. The genes of inhibitor of differentiation (ID) family play a major role in cell prol...

    Authors: Shirin Amirteimouri, Manan Ashini, Fariba Ramazanali, Reza Aflatoonian, Parvaneh Afsharian and Maryam Shahhoseini

    Citation: Reproductive Biology and Endocrinology 2019 17:32

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  36. Content type: Correction

    .

    Authors: Alessandro Conforti, Sandro C. Esteves, Francesca Di Rella, Ida Strina, Pasquale De Rosa, Alessia Fiorenza, Fulvio Zullo, Giuseppe De Placido and Carlo Alviggi

    Citation: Reproductive Biology and Endocrinology 2019 17:31

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    The original article was published in Reproductive Biology and Endocrinology 2019 17:18

  37. Content type: Research

    In order to maximize In vitro fertilization (IVF) success rates in advanced- age patients, it has been suggested to favor the use of intracytoplasmic sperm injection (ICSI) over conventional insemination (CI),...

    Authors: Jacob Farhi, Kfir Cohen, Yossi Mizrachi, Ariel Weissman, Arieh Raziel and Raoul Orvieto

    Citation: Reproductive Biology and Endocrinology 2019 17:30

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  38. Content type: Research

    Proteomic studies of follicular fluid (FF) exist for several species, including the horse; however, the seasonal influence on FF proteome has not been explored in livestock. The application of high-throughput ...

    Authors: G. A. Dutra, G. M. Ishak, O. Pechanova, T. Pechan, D. G. Peterson, J. C. F. Jacob, S. T. Willard, P. L. Ryan, E. L. Gastal and J. M. Feugang

    Citation: Reproductive Biology and Endocrinology 2019 17:29

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  39. Content type: Research

    Syndecan-1 is a heparan sulfate proteoglycan acting as a co-receptor for cytokines and growth factors mediating developmental, immunological and angiogenic processes. In human, the uteroplacental localization ...

    Authors: Christina Gougoula, Alexandra P. Bielfeld, Sarah J. Pour, Jan-S. Krüssel, Martin Götte, W. Peter M. Benten and Dunja M. Baston-Büst

    Citation: Reproductive Biology and Endocrinology 2019 17:28

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  40. Content type: Research

    Some studies have suggested that blastocyst transfer is associated with i) imbalance in the secondary sex ratio (SSR) (which favors male offspring), ii) increased incidence of monozygotic twins (MZT). In contr...

    Authors: Hiromitsu Hattori, Akane Kitamura, Fumiaki Takahashi, Norio Kobayashi, Akiko Sato, Naoko Miyauchi, Hidekazu Nishigori, Satoshi Mizuno, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Nozomi Tatsuta, Ichiko Nishijima, Ikuma Fujiwara, Shinichi Kuriyama, Hirohito Metoki…

    Citation: Reproductive Biology and Endocrinology 2019 17:27

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  41. Content type: Research

    Hormonal contraceptives, particularly depot medroxyprogesterone acetate (DMPA), have been reported to be associated with substantially enhanced HIV acquisition; however, the biological mechanisms of this risk ...

    Authors: Liping Li, Jie Zhou, Weijia Wang, Lina Huang, Jiaoqin Tu, Lyndsey Baiamonte, Moselle Stark, Mistie Mills, Thomas J. Hope, Erma Z. Drobnis, Alison J. Quayle and Danny J. Schust

    Citation: Reproductive Biology and Endocrinology 2019 17:26

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  42. Content type: Research

    In dairy cows, the energy cost of milk yield results in a negative energy balance (EB) and body fat mobilization that impairs reproductive efficiency. Emerging evidence suggests that the novel adipokines, Reti...

    Authors: Namya Mellouk, Christelle Ramé, Mélodie Diot, Eric Briant, Jean-Luc Touzé, Daniel Guillaume, Pascal Froment and Joëlle Dupont

    Citation: Reproductive Biology and Endocrinology 2019 17:25

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  43. Content type: Research

    Infertile men have higher levels of semen reactive oxygen species (ROS) than fertile men. High levels of semen ROS can cause sperm dysfunction, sperm DNA damage and reduced male reproductive potential. This st...

    Authors: Rahil Jannatifar, Kazem Parivar, Nasim Hayati Roodbari and Mohammad Hossein Nasr-Esfahani

    Citation: Reproductive Biology and Endocrinology 2019 17:24

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  44. Content type: Research

    Age-associated infertility is a problem worldwide, and management of oxidative stress is known to be essential. Nuclear factor-E2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1)-antioxidant...

    Authors: Nana Akino, Osamu Wada-Hiraike, Wataru Isono, Hiromi Terao, Harunori Honjo, Yuichiro Miyamoto, Michihiro Tanikawa, Kenbun Sone, Mana Hirano, Miyuki Harada, Tetsuya Hirata, Yasushi Hirota, Kaori Koga, Katsutoshi Oda, Tomoyuki Fujii and Yutaka Osuga

    Citation: Reproductive Biology and Endocrinology 2019 17:23

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  45. Content type: Research

    Previous studies, which were primarily based on the fluorescent in-situ hybridisation (FISH) technique, revealed conflicting evidence regarding male foetal microchimerism in endometriosis. FISH is a relatively...

    Authors: Muzaffer A. Bhat, Jai B. Sharma, Kallol K. Roy, Jayasree Sengupta and Debabrata Ghosh

    Citation: Reproductive Biology and Endocrinology 2019 17:22

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  46. Content type: Research

    Endometriosis is thought to affect the effectiveness of ART by an increased risk of miscarriage. We aimed to investigate the impact of endometriosis in women achieving singleton pregnancies through IVF fresh c...

    Authors: Puyu Yang, Yang Wang, Zhangxin Wu, Ningning Pan, Liying Yan and Caihong Ma

    Citation: Reproductive Biology and Endocrinology 2019 17:21

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  47. Content type: Research

    Despite being born with a significant number of primordial cells which representing the ancestor cells of the germ-line, women experience a depletion of ovarian reserve and sub-fertility mid-way into their hea...

    Authors: Haroon Latif Khan, Shahzad Bhatti, Samina Suhail, Rohina Gul, Aisha Awais, Humaira Hamayun, Farah Enver, Sana Abbas, Zahira Hassan, Rameen Nisar, Saba Sardar and Warda Asif

    Citation: Reproductive Biology and Endocrinology 2019 17:20

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  48. Content type: Research

    Steroidogenesis is an indispensable process that is indirectly associated with spermatogenesis in the Leydig cell (LC) to utilize the lipid droplets (LDs) that are critical to maintaining normal testosterone s...

    Authors: Imran Tarique, Waseem Ali Vistro, Xuebing Bai, Ping Yang, Chen Hong, Yufei Huang, Abdul Haseeb, Enxue Liu, Noor Samad Gandahi, Mengdi Xu, Yifei Liu and Qiusheng Chen

    Citation: Reproductive Biology and Endocrinology 2019 17:19

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