Articles

Comparisons of benefits and risks of single embryo transfer versus double embryo transfer: a systematic review and meta-analysis

Evidence referring to the trade-offs between the benefits and risks of single embryo transfer (SET) versus double embryo transfer (DET) following assisted reproduction technology are insufficient, especially f...

Authors: Shujuan Ma, Yangqin Peng, Liang Hu, Xiaojuan Wang, Yiquan Xiong, Yi Tang, Jing Tan and Fei Gong

Interplay between nitric oxide and gonadotrophin-releasing hormone in the neuromodulation of the corpus luteum during late pregnancy in the rat

Nitric oxide and GnRH are biological factors that participate in the regulation of reproductive functions. To our knowledge, there are no studies that link NO and GnRH in the sympathetic ganglia. Thus, the aim...

Authors: Sandra Vallcaneras, Laura Morales, María Belén Delsouc, Darío Ramirez, Verónica Filippa, Marina Fernández, Carlos M. Telleria and Marilina Casais

Recombinant anti-Müllerian hormone in the maturation medium improves the in vitro maturation of human immature (GV) oocytes after controlled ovarian hormonal stimulation

In vitro maturation (IVM) of oocytes is a laboratory method that allows the maturation of immature (GV) oocytes retrieved from patients enrolled in the in vitro fertilization (IVF) programme. However, this met...

Authors: Jure Bedenk, Tadeja Režen, Taja Železnik Ramuta, Nina Jančar, Eda Vrtačnik Bokal, Ksenija Geršak and Irma Virant Klun

Zinc transporter ZIP12 maintains zinc homeostasis and protects spermatogonia from oxidative stress during spermatogenesis

Overwhelming evidences suggest oxidative stress is a major cause of sperm dysfunction and male infertility. Zinc is an important non-enzymatic antioxidant with a wide range of biological functions and plays a ...

Authors: Xinye Zhu, Chengxuan Yu, Wangshu Wu, Lei Shi, Chenyi Jiang, Li Wang, Zhide Ding and Yue Liu

Impact of sleep patterns upon female neuroendocrinology and reproductive outcomes: a comprehensive review

Sleep is vital to human bodily function. Growing evidence indicates that sleep deprivation, disruption, dysrhythmia, and disorders are associated with impaired reproductive function and poor clinical outcomes ...

Authors: Gabriela Beroukhim, Ecem Esencan and David B. Seifer

A comparative, observational study evaluating dosing characteristics and ovarian response using the recombinant human follicle-stimulating hormone pen injector with small-dose dial in assisted reproductive technologies treatment in Asia: IMPROVE study

Ovarian stimulation during medically assisted reproduction treatment should be individualized to optimize outcomes and reduce complications. This study assessed whether use of the recombinant human follicle-st...

Authors: Bum Chae Choi, Canquan Zhou, Hong Ye, Yun Sun, Ying Zhong, Fei Gong, Ivan Sini, Nadezda Abramova, Salvatore Longobardi, Miranda Hickey and Thomas D’Hooghe

Human plasma pregnancy-associated miRNAs and their temporal variation within the first trimester of pregnancy

During pregnancy, maternal metabolism undergoes substantial changes to support the developing fetus. Such changes are finely regulated by different mechanisms carried out by effectors such as microRNAs (miRNAs...

Authors: Cécilia Légaré, Andrée-Anne Clément, Véronique Desgagné, Kathrine Thibeault, Frédérique White, Simon-Pierre Guay, Benoit J. Arsenault, Michelle S. Scott, Pierre-Étienne Jacques, Patrice Perron, Renée Guérin, Marie-France Hivert and Luigi Bouchard

Transcriptome analysis of eutopic endometrium in adenomyosis after GnRH agonist treatment

Adenomyosis is a chronic gynecological disease characterized by invasion of the uterine endometrium into the muscle layer. In assisted reproductive technology (ART), gonadotropin-releasing hormone agonist (GnR...

Authors: Jiao Tian, Nannan Kang, Junxia Wang, Haixiang Sun, Guijun Yan, Chenyang Huang and Jie Mei

Polycystic ovary syndrome as a plausible evolutionary outcome of metabolic adaptation

As a common endocrinopathy of reproductive-aged women, polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, oligo-anovulation and polycystic ovarian morphology. It is linked with insulin resi...

Authors: Daniel A. Dumesic, Vasantha Padmanabhan, Gregorio D. Chazenbalk and David H. Abbott

Endometrial injury concurrent with hysteroscopy increases the expression of Leukaemia inhibitory factor: a preliminary study

It is not known by which mechanism endometrial injury increases pregnancy rates. Leukaemia inhibitory factor (LIF) is a cytokine involved in wound healing and implantation. The aim of this study was to determi...

Authors: Suat Suphan Ersahin and Aynur Ersahin

Oocyte cryopreservation review: outcomes of medical oocyte cryopreservation and planned oocyte cryopreservation

The utilization of oocyte cryopreservation (OC) has become popularized with increasing numbers of reproductive-aged patients desiring to maintain fertility for future family building. OC was initially used for...

Authors: Zachary Walker, Andrea Lanes and Elizabeth Ginsburg

EndMT: New findings on the origin of myofibroblasts in endometrial fibrosis of intrauterine adhesions

Intrauterine adhesion (IUA) is one of the leading causes of infertility and the main clinical challenge is the high recurrence rate. The key to solving this dilemma lies in elucidating the mechanisms of endome...

Authors: Chengcheng Xu, Meng Bao, Xiaorong Fan, Jin Huang, Changhong Zhu and Wei Xia

Preeclampsia at delivery is associated with lower serum vitamin D and higher antiangiogenic factors: a case control study

Preeclampsia is characterized by decreased trophoblastic angiogenesis leading to abnormal invasion of spiral arteries, shallow implantation and resulting in compromised placentation with poor uteroplacental pe...

Authors: David B. Seifer, Geralyn Lambert-Messerlian, Glenn E. Palomaki, Robert M. Silver, Corette Parker, Carol J. Rowland Hogue, Barbara J. Stoll, George R. Saade, Robert L. Goldenberg, Donald J. Dudley, Radek Bukowski, Halit Pinar and Uma M. Reddy

Polycystic ovary syndrome phenotype does not have impact on oocyte morphology

The primary objective of the present study of women participating in an ICSI program was to determine whether the morphologic quality of oocytes was related to the polycystic ovary syndrome (PCOS) phenotype.

Authors: Audrey Uk, Christine Decanter, Camille Grysole, Laura Keller, Hélène Béhal, Mauro Silva, Didier Dewailly, Geoffroy Robin and Anne-Laure Barbotin

Hyperandrogenism and menstrual imbalance are the best predictors of metformin response in PCOS patients

Moving from the correlation between insulin-resistance and PCOS, metformin has been administered in some PCOS women improving ovulatory and metabolic functions and decreasing androgen levels. Inconsistency and...

Authors: Emanuele Garzia, Valentina Galiano, Giovanni Marfia, Stefania Navone, Enzo Grossi and Anna Maria Marconi

Homozygous mutation in SLO3 leads to severe asthenoteratozoospermia due to acrosome hypoplasia and mitochondrial sheath malformations

Potassium channels are important for the structure and function of the spermatozoa. As a potassium transporter, the mSlo3 is essential for male fertility as Slo3 knockout male mice were infertile with the series ...

Authors: Mingrong Lv, Chunyu Liu, Chunjie Ma, Hui Yu, Zhongmei Shao, Yang Gao, Yiyuan Liu, Huan Wu, Dongdong Tang, Qing Tan, Junqiang Zhang, Kuokuo Li, Chuan Xu, Hao Geng, Jingjing Zhang, Hang Li…

Elevated SAA1 promotes the development of insulin resistance in ovarian granulosa cells in polycystic ovary syndrome

Insulin resistance (IR) contributes to ovarian dysfunctions in polycystic ovarian syndrome (PCOS) patients. Serum amyloid A1 (SAA1) is an acute phase protein produced primarily by the liver in response to infl...

Authors: Qinling Zhu, Yue Yao, Lizhen Xu, Hasiximuke Wu, Wangsheng Wang, Yaqiong He, Yuan Wang, Yao Lu, Jia Qi, Ying Ding, Xinyu Li, Jiaan Huang, Hanting Zhao, Yanzhi Du, Kang Sun and Yun Sun

Proteomic analysis of extracellular vesicles secreted by primary human epithelial endometrial cells reveals key proteins related to embryo implantation

Successful implantation is dependent on coordination between maternal endometrium and embryo, and the role of EVs in the required cross-talk cell-to-cell has been recently established. In this regard, it has b...

Authors: Marina Segura-Benítez, María Cristina Carbajo-García, Ana Corachán, Amparo Faus, Antonio Pellicer and Hortensia Ferrero

Transcriptomics of receptive endometrium in women with sonographic features of adenomyosis

Women with uterine adenomyosis seeking assisted reproduction have been associated with compromised endometrial receptivity to embryo implantation. To understand the mechanisms involved in this process, we aime...

Authors: Erika Prašnikar, Tanja Kunej, Mario Gorenjak, Uroš Potočnik, Borut Kovačič and Jure Knez

A review of disparities in access to infertility care and treatment outcomes among Hispanic women

Hispanic women have lower rates of use of infertility services than non-Hispanic White women. There are many barriers that impede access to infertility care including economic, geographic, cultural, and societ...

Authors: Allison S. Komorowski and Tarun Jain

The effects of statins on hyperandrogenism in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials

Several clinical studies showed that statins were potential to treat polycystic ovary syndrome (PCOS). Through comprehensive search PubMed, EMBASE, the Web of Science, BIOSIS, the ClinialTrails.gov, and the Co...

Authors: Jianguo Chen, Chaoran Huang, Tongtong Zhang, Wuqing Gong, Xiaofeng Deng, Hua Liu, Jinbo Liu and Yuanbiao Guo

The inhibitory effect of AMP-activated protein kinase (AMPK) on chemokine and prostaglandin production in human endometrial stromal cells

To investigate the role of adenosine monophosphate (AMP)-activated protein kinase (AMPK) on the production of interleukin (IL)-8, monocyte chemoattractant protein (MCP)-1, prostaglandin E2 and F2α induced by I...

Authors: Yasushi Kawano, Hatsumi Sato, Kaori Goto, Masakazu Nishida and Kaei Nasu

Increased METTL3-mediated m⁶A methylation inhibits embryo implantation by repressing HOXA10 expression in recurrent implantation failure

Recurrent implantation failure (RIF) is a major limitation of assisted reproductive technology, which is associated with impaired endometrial receptivity. Although N⁶-methyladenosine (m⁶A) has been demonstrated t...

Authors: Pingping Xue, Wenbo Zhou, Wenqiang Fan, Jianya Jiang, Chengcai Kong, Wei Zhou, Jianmei Zhou, Xiaoyang Huang, Haiyan Yang, Qian Han, Bin Zhang, Lingyun Xu, Bin Yu and Li Chen

Association between clinical and IVF laboratory parameters and miscarriage after single euploid embryo transfers

The goal of this study was to investigate which factors, excluding embryo aneuploidies, are associated with miscarriage in patients who have undergone a single euploid blastocyst transfer.

Authors: María del Carmen Nogales, María Cruz, Silvia de Frutos, Eva María Martínez, María Gaytán, Marta Ariza, Fernando Bronet and Juan A. Garcia-Velasco

An artificial intelligence model (euploid prediction algorithm) can predict embryo ploidy status based on time-lapse data

For the association between time-lapse technology (TLT) and embryo ploidy status, there has not yet been fully understood. TLT has the characteristics of large amount of data and non-invasiveness. If we want t...

Authors: Bo Huang, Wei Tan, Zhou Li and Lei Jin

Exploration of the value of progesterone and progesterone/estradiol ratio on the hCG trigger day in predicting pregnancy outcomes of PCOS patients undergoing IVF/ICSI: a retrospective cohort study

Polycystic ovary syndrome (PCOS) is a common endocrine disorder with the disorders of estrogen(E2) and progesterone(P) secretion. The purpose of this study was to evaluate the association between the progester...

Authors: Yiqing Yang, Bowen Liu, Gengxiang Wu and Jing Yang

Analysis of maturation dynamics and developmental competence of in vitro matured oocytes under time-lapse monitoring

To improve the developmental competence of in vitro cultured oocytes, extensive literature focused on maturation rate improvement with different additives in culture medium, while studies investigating the mat...

Authors: Qiyu Yang, Lixia Zhu, Meng Wang, Bo Huang, Zhou Li, Juan Hu, Qingsong Xi, Jing Liu and Lei Jin

Recombinant follicular stimulating hormone plus recombinant luteinizing hormone versus human menopausal gonadotropins- does the source of LH bioactivity affect ovarian stimulation outcome?

Luteinizing hormone (LH) and human chorionic gonadotropin (hCG) activate distinct intracellular signaling cascades. However, due to their similar structure and common receptor, they are used interchangeably du...

Authors: M. Kirshenbaum, O. Gil, J. Haas, R. Nahum, E. Zilberberg, O. Lebovitz and R. Orvieto

Pak2 reduction induces a failure of early embryonic development in mice

The quality of the early embryo is vital to embryonic development and implantation. As a highly conserved serine/threonine kinase, p21-activated kinase 2 (Pak2) participates in diverse biologic processes, espe...

Authors: Juan Zeng, Nengqing Liu, Yinghong Yang, Yi Cheng, Yuanshuai Li, Xiaoxia Guo, Qian Luo, Lifen Zhu, Hongmei Guan, Bing Song and Xiaofang Sun

MicroRNA signatures in plasma and plasma exosome during window of implantation for implantation failure following in-vitro fertilization and embryo transfer

MicroRNAs (miRNAs) are small, non-coding RNAs that are dysregulated in many diseases and can act as biomarkers. Although well-studied in cancer, the role of miRNAs in embryo implantation is poorly understood. ...

Authors: Hong Zeng, Yu Fu, Lang Shen and Song Quan

Impact of perioperative use of GnRH agonist or dienogest on ovarian reserve after cystectomy for endometriomas: a randomized controlled trial

Ovarian endometrioma is a common gynecological disease that is often treated with surgery or hormonal treatment. Ovarian cystectomy, a surgical procedure for ovarian endometrioma, can result in impaired ovaria...

Authors: Ayako Muraoka, Satoko Osuka, Atsushi Yabuki, Bayasula, Masato Yoshihara, Hideaki Tanaka, Reina Sonehara, Natsuki Miyake, Mayuko Murakami, Sayako Yoshita, Natsuki Nakanishi, Tomoko Nakamura, Maki Goto, Akira Iwase and Hiroaki Kajiyama

Circulating tumor DNA: a noninvasive biomarker for tracking ovarian cancer

Ovarian cancer is the fifth leading cause of cancer-related mortality in women worldwide. Despite the development of technologies over decades to improve the diagnosis and treatment of patients with ovarian ca...

Authors: Fang Yang, Jun Tang, Zihao Zhao, Chunling Zhao and Yuancai Xiang

Circulating noncoding RNAs as early predictive biomarkers in preeclampsia: a diagnostic meta-analysis

We designed a meta-analysis to evaluate the clinical significance and efficacy of circulating noncoding RNAs (ncRNAs) in the early prediction of preeclampsia.

Authors: Sha Su, Fang Yang, Linlin Zhong and Lihong Pang

CircCRIM1 promotes ovarian cancer progression by working as ceRNAs of CRIM1 and targeting miR-383-5p/ZEB2 axis

Ovarian cancer is the leading cause of death in patients with gynecologic cancer, and circular RNAs (circRNAs) are involved in cancer progression. However, there are limited studies on the roles of circRNAs in...

Authors: Yuping Du, Xin Liu, Song Zhang, Shuo Chen, Xue Guan, Qianhui Li, Xi Chen and Yang Zhao

Involvement of impaired CD8⁺ mucosal-associated invariant T cells and myeloid-derived suppressor cells in polycystic ovary syndrome

Immune dysfunction is one of the mechanisms to promote polycystic ovary syndrome (PCOS). Various immune cells have been reported to be involved in the development of PCOS. Meanwhile, the disturbance of metabol...

Authors: Mengting Zhu, Yuping Xu, Caihua Li, Zhimin Lu, Kaihuan Bi, Kangxia Wang, Peipei Guo, Huanhuan Jiang and Yunxia Cao

Differences in ICSI utilization rates among states with insurance mandates for ART coverage

Assisted reproductive technology (ART) insurance mandates promote more selective utilization of ART clinic resources including intracytoplasmic sperm injection (ICSI). Our objective was to examine whether ICSI...

Authors: Pavel Zagadailov, Kyung S. Cho and David B. Seifer

Bone morphogenetic protein 2 inhibits growth differentiation factor 8-induced cell signaling via upregulation of gremlin2 expression in human granulosa-lutein cells

Bone morphogenetic protein 2 (BMP2), growth differentiation factor 8 (GDF8) and their functional receptors are expressed in human ovarian follicles, and these two intrafollicular factors play essential roles i...

Authors: Xiaoyan Luo, Hsun-Ming Chang, Yuyin Yi, Yingpu Sun and Peter C. K. Leung

Characteristics of the cytoplasmic halo during fertilisation correlate with the live birth rate after fresh cleaved embryo transfer on day 2 in minimal ovarian stimulation cycles: a retrospective observational study

Information regarding the influence of cytoplasmic events during fertilisation on the clinical outcome remains limited. The cytoplasmic halo is one of these events. A previous study that used time-lapse techno...

Authors: Kenji Ezoe, Tetsuya Miki, Tadashi Okimura, Kazuo Uchiyama, Akiko Yabuuchi, Tamotsu Kobayashi and Keiichi Kato

The altered immunological status of children conceived by assisted reproductive technology

With the increased use of assisted reproductive technology (ART), assessing the potential health risks of children conceived on ART important to public health. Most research in this area has focused on the eff...

Authors: Xin Xu, Han Wu, Yuehong Bian, Linlin Cui, Yuanyuan Man, Zhao Wang, Xin Zhang, Changming Zhang and Ling Geng

microRNA-194 is increased in polycystic ovary syndrome granulosa cell and induce KGN cells apoptosis by direct targeting heparin-binding EGF-like growth factor

Polycystic ovary syndrome (PCOS) is an endocrine-related follicular developmental disorder that affects 50 %-70 % of reproductive-aged women diagnosed with ovulation-related infertility. Abnormal proliferation...

Authors: Yi-xuan Wu, Yan-shan Lin, Si-chen Li, Xi Yao, Mingwei Cheng, Lin Zhu and Hai-ying Liu

Correction to: Evaluation of intra-ovarian platelet-rich plasma administration on oocytes-dependent variables in patients with poor ovarian response: a retrospective study according to the POSEIDON criteria

Authors: Marzieh Farimani, Arash Nazari, Shahrzad Mohammadi and Roghayeh Anvari Aliabad

Icariin improves testicular dysfunction via enhancing proliferation and inhibiting mitochondria-dependent apoptosis pathway in high-fat diet and streptozotocin-induced diabetic rats

Diabetes mellitus (DM), a chronic metabolic disease, severely impairs male reproductive function. However, the underpinning mechanisms are still incompletely defined, and there are no effective strategies or m...

Authors: Weiguo He, Huiqing Liu, Linlin Hu, Yaohui Wang, Lane Huang, Aihong Liang, Xuan Wang, Qing Zhang, Yi Chen, Yi Cao, Suyun Li, Junli Wang and Xiaocan Lei

Circ_0043532 regulates miR-182/SGK3 axis to promote granulosa cell progression in polycystic ovary syndrome

Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disease in women at childbearing age. Several circular RNAs (circRNAs) have been demonstrated to be involved in PCOS. In this study, we aime...

Authors: Lishuang Xu, Fang Xiong, Yinyang Bai, Juxia Xiao, Yun Zhang, Jie Chen and Qiuping Li

Diet normalization or caloric restriction as a preconception care strategy to improve metabolic health and oocyte quality in obese outbred mice

Maternal metabolic disorders are linked to reduced metabolic health and oocyte quality. Obese women are advised to lose weight before conception to increase pregnancy chances. However, as human studies show no...

Authors: Anouk Smits, Waleed F. A. Marei, Diane De Neubourg and Jo L. M. R. Leroy

Pregnancy-related complications and perinatal outcomes following progesterone supplementation before 20 weeks of pregnancy in spontaneously achieved singleton pregnancies: a systematic review and meta-analysis

Progesterone supplementation is widely performed in women with threatened miscarriage or a history of recurrent miscarriage; however, the effects of early progesterone supplementation on pregnancy-related comp...

Authors: Hanglin Wu, Songying Zhang, Xiaona Lin, Jing He, Shasha Wang and Ping Zhou

Corpus luteum number and the maternal renin-angiotensin-aldosterone system as determinants of utero-placental (vascular) development: the Rotterdam Periconceptional Cohort

Pregnancies with > 1 corpus luteum (CL) display a hyperdynamic circulation and an increased risk of small-for-gestational age deliveries. Among the factors released by the CL is prorenin, the inactive precurso...

Authors: Rosalieke E. Wiegel, Maud J. H. Karsten, Igna F. Reijnders, Lenie van Rossem, Sten P. Willemsen, Annemarie G. M. G. J. Mulders, Anton H. J. Koning, Eric A. P. Steegers, A. H. Jan Danser and Régine P. M. Steegers-Theunissen

DNA methylation and gene expression changes in mouse pre- and post-implantation embryos generated by intracytoplasmic sperm injection with artificial oocyte activation

The application of artificial oocyte activation (AOA) after intracytoplasmic sperm injection (ICSI) is successful in mitigating fertilization failure problems in assisted reproductive technology (ART). Neverth...

Authors: Mingru Yin, Weina Yu, Wenzhi Li, Qianqian Zhu, Hui Long, Pengcheng Kong and Qifeng Lyu

Effects of Aurora kinase A on mouse decidualization via Stat3-plk1-cdk1 pathway

Decidualization is essential to the successful pregnancy in mice. The molecular mechanisms and effects of Aurora kinase A (Aurora A) remain poorly understood during pregnancy. This study is the first to invest...

Authors: Peng-Chao Wang, Si-Ting Chen and Zeng-Ming Yang

WEE1 promotes endometriosis via the Wnt/β-catenin signaling pathway

Endometriosis, the presence of active endometrial tissue outside the lining membrane of the uterine cavity, is a common disease in women of childbearing age. The ectopic endometrium has some characteristics of...

Authors: Liya Shi, Xue Xue, Hui Tian, Hongjuan Ye, Hui Wang, Rongxiang Wang, Yu Liu, Caixia Zhang, Qiuju Chen and Lihua Sun

Impact of endometriosis on oocyte morphology in IVF-ICSI: retrospective study of a cohort of more than 6000 mature oocytes

Infertility associated with endometriosis can be explained by several non-exclusive mechanisms. The oocyte plays a crucial role in determining embryonic competence and this is particularly relevant for in vitr...

Authors: Camille Robin, Audrey Uk, Christine Decanter, Hélène Behal, Pierre Collinet, Chrystèle Rubod, Anne-Laure Barbotin and Geoffroy Robin