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  1. The protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway regulates early follicular activation and follicular pool maintenance in female germline cells. Fragile X mental retardation 1 (FM...

    Authors: Julia Rehnitz, Birgitta Messmer, Ulrike Bender, Xuan Phuoc Nguyen, Ariane Germeyer, Katrin Hinderhofer, Thomas Strowitzki and Edison Capp
    Citation: Reproductive Biology and Endocrinology 2022 20:44
    Content type: Research Published on:

  2. The heavy metal cadmium is proposed to be one of the environmental endocrine disruptors of spermatogenesis. Cadmium-induced inhibition of spermatogenesis is associated with a hormone secretion disorder. Letroz...

    Authors: Yao Yao, Yangyang Wan, Xiaoyun Shi, Lan Guo, Hui Jiang, Xiansheng Zhang, Bo Xu and Juan Hua
    Citation: Reproductive Biology and Endocrinology 2022 20:43
    Content type: Research Published on:

  3. Bone morphogenetic protein 15 (BMP15) is expressed in oocytes and plays a crucial role in the reproduction of mono-ovulating species. In humans, BMP15 gene mutations lead to imperfect protein function and prematu...

    Authors: Fatemeh Afkhami, Shirin Shahbazi, Laya Farzadi and Shahla Danaei
    Citation: Reproductive Biology and Endocrinology 2022 20:42
    Content type: Research Published on:

  4. Multiple morphological abnormalities of the sperm flagella (MMAF) is a subtype of severe asthenoteratozoospermia with poorly understood genetic etiology. SPAG6 is a core axonemal component that plays a critica...

    Authors: Chuan Xu, Dongdong Tang, Zhongmei Shao, Hao Geng, Yang Gao, Kuokuo Li, Qing Tan, Guanxiong Wang, Chao Wang, Huan Wu, Guanjian Li, Mingrong Lv, Xiaojin He and Yunxia Cao
    Citation: Reproductive Biology and Endocrinology 2022 20:41
    Content type: Research Published on:

    The Correction to this article has been published in Reproductive Biology and Endocrinology 2022 20:74

  5. The use of frozen embryo transfer in assisted reproductive technology (ART) has steadily increased since development in the early 1980’s. While there are many benefits to delayed frozen embryo transfer, certai...

    Authors: Jacqueline C. Lee, Martina L. Badell and Jennifer F. Kawwass
    Citation: Reproductive Biology and Endocrinology 2022 20:40
    Content type: Review Published on:

  6. Premature ovarian failure (POF) is a serious problem for young women who receive chemotherapy, and its pathophysiological basis is the dysfunction of granulosa cells. According to previous reports, menstrual-d...

    Authors: Rongli Wang, Wei Wang, Lijun Wang, Linnan Yuan, Feiyan Cheng, Xin Guan, Nini Zheng and Xinyuan Yang
    Citation: Reproductive Biology and Endocrinology 2022 20:39
    Content type: Research Published on:

  7. Preeclampsia (PE), a pregnancy disorder that affects 5–7% of pregnant women, is among the primary causes for maternal and perinatal mortality. PE is believed to be associated with insufficient invasion of vill...

    Authors: Junjie Zang, Min Yan, Yan Zhang, Wei Peng, Jianxin Zuo, Huansheng Zhou, Guoqiang Gao, Min Li, Yijing Chu and Yuanhua Ye
    Citation: Reproductive Biology and Endocrinology 2022 20:38
    Content type: Research Published on:

  8. In vitro fertilization (IVF) is currently one of the most effective methods of infertility treatment. An alternative to commonly used ovarian hyperstimulation can become extracorporeal maturation of oocytes (i...

    Authors: Patrycja Strączyńska, Krzysztof Papis, Emilia Morawiec, Michał Czerwiński, Zdzisław Gajewski, Anita Olejek and Anna Bednarska-Czerwińska
    Citation: Reproductive Biology and Endocrinology 2022 20:37
    Content type: Review Published on:

  9. In early pregnancy, differentiating between a normal intrauterine pregnancy (IUP) and abnormal gestations including early pregnancy loss (EPL) or ectopic pregnancy (EP) is a major clinical challenge when ultra...

    Authors: Lynn A. Beer, Suneeta Senapati, Mary D. Sammel, Kurt T. Barnhart, Courtney A. Schreiber and David W. Speicher
    Citation: Reproductive Biology and Endocrinology 2022 20:36
    Content type: Research Published on:

  10. Ovarian tissue cryopreservation and transplantation (OTCTP) is currently the main option available to preserve fertility in prepubertal patients undergoing aggressive cancer therapy treatments. However, a majo...

    Authors: Carmen Terren, Jules Bindels, Michelle Nisolle, Agnès Noël and Carine Munaut
    Citation: Reproductive Biology and Endocrinology 2022 20:35
    Content type: Short communication Published on:

  11. Growth differentiation factor-11 (GDF-11) belongs to the transforming growth factor-β (TGF-β) superfamily. To date, the expression of GDF-11 in the ovary and its role in regulating ovarian function are complet...

    Authors: Qiongqiong Jia, Boqun Liu, Xuan Dang, Yanjie Guo, Xiaoyu Han, Tinglin Song, Jung-Chien Cheng and Lanlan Fang
    Citation: Reproductive Biology and Endocrinology 2022 20:34
    Content type: Research Published on:

  12. Growing evidence suggests that adherence to certain dietary patterns is associated with improved fecundity and reproductive outcomes in the general population and infertile couples assisted reproductive treatm...

    Authors: Ashley M. Eskew, Bronwyn S. Bedrick, Jorge E. Chavarro, Joan K. Riley and Emily S. Jungheim
    Citation: Reproductive Biology and Endocrinology 2022 20:33
    Content type: Research Published on:

  13. Polycystic ovary syndrome (PCOS) is a common endocrine disorder among reproductive-age women. The mechanism by which circular RNA (circRNA) drives PCOS development remains unclear. Thus, the study is designed ...

    Authors: Xia Xu, Rui Guan, Ke Gong, Huaibing Xie and Lei Shi
    Citation: Reproductive Biology and Endocrinology 2022 20:32
    Content type: Research Published on:

  15. Polycystic Ovary Syndrome (PCOS) is an endocrine disorder that affects women in reproductive age and represents an unfavourable risk factor for several pregnancy and perinatal outcomes. Despite, no guidelines ...

    Authors: Romina Fornes, Johanna Simin, Minh Hanh Nguyen, Gonzalo Cruz, Nicolás Crisosto, Maartje van der Schaaf, Lars Engstrand and Nele Brusselaers
    Citation: Reproductive Biology and Endocrinology 2022 20:30
    Content type: Research Published on:

  16. Several surveys have reported that patients treated with gonadotropin-releasing hormone antagonist (GnRH-ant) protocol showed a significantly lower rate of implantation and clinical pregnancy compared to GnRH ...

    Authors: Ding-Fei Xu, Pei-Pei Liu, Lu Fan, Qi Xie, Zhi-Qin Zhang, Li-Qun Wang, Qiong-Fang Wu and Jun Tan
    Citation: Reproductive Biology and Endocrinology 2022 20:29
    Content type: Research Published on:

  17. Primary ovarian insufficiency (POI) is a rare gynecological condition. This disease causes menstrual disturbances, infertility, and various health problems. Historically, hormone replacement therapy is the fir...

    Authors: Qiao-yi Huang, Shao-rong Chen, Jia-ming Chen, Qi-yang Shi and Shu Lin
    Citation: Reproductive Biology and Endocrinology 2022 20:28
    Content type: Review Published on:

    The Correction to this article has been published in Reproductive Biology and Endocrinology 2023 21:81

  18. Gestational trophoblastic disease (GTD) usually affects young women of childbearing age. After treatment for GTD, 86% of women wish to achieve pregnancy. On account of the impacts of GTD and treatments as well...

    Authors: Xinyu Cai, Mei Zhang, Chenyang Huang, Yue Jiang, Jidong Zhou, Manlin Xu, Guijun Yan, Haixiang Sun and Na Kong
    Citation: Reproductive Biology and Endocrinology 2022 20:27
    Content type: Research Published on:

  19. To determine whether gonadotropin-releasing hormone (GnRH) agonist downregulation combined with hormone replacement therapy (HRT) can improve the reproductive outcomes in frozen–thawed embryo transfer cycles f...

    Authors: Dan Pan, Jie Yang, Ni Zhang, Lei Wang, Na Li, Juanzi Shi and Hanying Zhou
    Citation: Reproductive Biology and Endocrinology 2022 20:26
    Content type: Research Published on:

  20. Thin endometrium (TE) is a challenging clinical issue in the reproductive medicine characterized by inadequate endometrial thickness, poor response to estrogen and no effective treatments currently. At present...

    Authors: Qi Zhu, Simin Yao, Yishan Dong, Dan Liu, Huiyan Wang, Peipei Jiang, Chenyan Dai, Haining Lv, Chenrui Cao, Zhenhua Zhou, Limin Wang, Wenjing Gou, Xiwen Zhang, Guangfeng Zhao and Yali Hu
    Citation: Reproductive Biology and Endocrinology 2022 20:25
    Content type: Research Published on:

  21. The normal physiological function of LH requires a certain concentration range, but because of pituitary desensitization, even on the day of HCG, endogenous levels of LH are low in the follicular-phase long pr...

    Authors: Wenjuan Zhang, Zhaozhao Liu, Manman Liu, Jiaheng Li and Yichun Guan
    Citation: Reproductive Biology and Endocrinology 2022 20:24
    Content type: Research Published on:

  22. The present study aimed to evaluate pregnancy and neonatal outcomes in women, with a previous history of wedge resection for interstitial pregnancy, in frozen-thawed embryo transfer (FET) cycles of IVF/ICSI.

    Authors: Shengluan Tang, Tong Du, Jialyu Huang, Hongjuan Ye, Ming Zhao, Jiaying Lin and Yanping Kuang
    Citation: Reproductive Biology and Endocrinology 2022 20:23
    Content type: Research Published on:

  23. Tightly regulation of extravillous cytotrophoblast (EVT) cell invasion is critical for the placentation and establishment of a successful pregnancy. Insufficient EVT cell invasion leads to the development of p...

    Authors: Lanlan Fang, Yang Yan, Yibo Gao, Ze Wu, Zhen Wang, Sizhu Yang, Jung-Chien Cheng and Ying-Pu Sun
    Citation: Reproductive Biology and Endocrinology 2022 20:22
    Content type: Research Published on:

  24. Non-obstructive azoospermia (NOA) is one of the most severe type in male infertility, and the genetic causes of NOA with meiotic arrest remain elusive.

    Authors: Peng Li, Zhiyong Ji, Erlei Zhi, Yuxiang Zhang, Sha Han, Liangyu Zhao, Ruhui Tian, Huixing Chen, Yuhua Huang, Jing Zhang, Huirong Chen, Fujun Zhao, Zhi Zhou, Zheng Li and Chencheng Yao
    Citation: Reproductive Biology and Endocrinology 2022 20:21
    Content type: Research Published on:

  25. Evidence referring to the trade-offs between the benefits and risks of single embryo transfer (SET) versus double embryo transfer (DET) following assisted reproduction technology are insufficient, especially f...

    Authors: Shujuan Ma, Yangqin Peng, Liang Hu, Xiaojuan Wang, Yiquan Xiong, Yi Tang, Jing Tan and Fei Gong
    Citation: Reproductive Biology and Endocrinology 2022 20:20
    Content type: Review Published on:

  26. Nitric oxide and GnRH are biological factors that participate in the regulation of reproductive functions. To our knowledge, there are no studies that link NO and GnRH in the sympathetic ganglia. Thus, the aim...

    Authors: Sandra Vallcaneras, Laura Morales, María Belén Delsouc, Darío Ramirez, Verónica Filippa, Marina Fernández, Carlos M. Telleria and Marilina Casais
    Citation: Reproductive Biology and Endocrinology 2022 20:19
    Content type: Research Published on:

  27. In vitro maturation (IVM) of oocytes is a laboratory method that allows the maturation of immature (GV) oocytes retrieved from patients enrolled in the in vitro fertilization (IVF) programme. However, this met...

    Authors: Jure Bedenk, Tadeja Režen, Taja Železnik Ramuta, Nina Jančar, Eda Vrtačnik Bokal, Ksenija Geršak and Irma Virant Klun
    Citation: Reproductive Biology and Endocrinology 2022 20:18
    Content type: Research Published on:

  28. Overwhelming evidences suggest oxidative stress is a major cause of sperm dysfunction and male infertility. Zinc is an important non-enzymatic antioxidant with a wide range of biological functions and plays a ...

    Authors: Xinye Zhu, Chengxuan Yu, Wangshu Wu, Lei Shi, Chenyi Jiang, Li Wang, Zhide Ding and Yue Liu
    Citation: Reproductive Biology and Endocrinology 2022 20:17
    Content type: Research Published on:

  29. Sleep is vital to human bodily function. Growing evidence indicates that sleep deprivation, disruption, dysrhythmia, and disorders are associated with impaired reproductive function and poor clinical outcomes ...

    Authors: Gabriela Beroukhim, Ecem Esencan and David B. Seifer
    Citation: Reproductive Biology and Endocrinology 2022 20:16
    Content type: Review Published on:

  30. Ovarian stimulation during medically assisted reproduction treatment should be individualized to optimize outcomes and reduce complications. This study assessed whether use of the recombinant human follicle-st...

    Authors: Bum Chae Choi, Canquan Zhou, Hong Ye, Yun Sun, Ying Zhong, Fei Gong, Ivan Sini, Nadezda Abramova, Salvatore Longobardi, Miranda Hickey and Thomas D’Hooghe
    Citation: Reproductive Biology and Endocrinology 2022 20:15
    Content type: Research Published on:

  31. During pregnancy, maternal metabolism undergoes substantial changes to support the developing fetus. Such changes are finely regulated by different mechanisms carried out by effectors such as microRNAs (miRNAs...

    Authors: Cécilia Légaré, Andrée-Anne Clément, Véronique Desgagné, Kathrine Thibeault, Frédérique White, Simon-Pierre Guay, Benoit J. Arsenault, Michelle S. Scott, Pierre-Étienne Jacques, Patrice Perron, Renée Guérin, Marie-France Hivert and Luigi Bouchard
    Citation: Reproductive Biology and Endocrinology 2022 20:14
    Content type: Research Published on:

  32. Adenomyosis is a chronic gynecological disease characterized by invasion of the uterine endometrium into the muscle layer. In assisted reproductive technology (ART), gonadotropin-releasing hormone agonist (GnR...

    Authors: Jiao Tian, Nannan Kang, Junxia Wang, Haixiang Sun, Guijun Yan, Chenyang Huang and Jie Mei
    Citation: Reproductive Biology and Endocrinology 2022 20:13
    Content type: Research Published on:

  33. As a common endocrinopathy of reproductive-aged women, polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, oligo-anovulation and polycystic ovarian morphology. It is linked with insulin resi...

    Authors: Daniel A. Dumesic, Vasantha Padmanabhan, Gregorio D. Chazenbalk and David H. Abbott
    Citation: Reproductive Biology and Endocrinology 2022 20:12
    Content type: Review Published on:

  34. It is not known by which mechanism endometrial injury increases pregnancy rates. Leukaemia inhibitory factor (LIF) is a cytokine involved in wound healing and implantation. The aim of this study was to determi...

    Authors: Suat Suphan Ersahin and Aynur Ersahin
    Citation: Reproductive Biology and Endocrinology 2022 20:11
    Content type: Research Published on:

  35. The utilization of oocyte cryopreservation (OC) has become popularized with increasing numbers of reproductive-aged patients desiring to maintain fertility for future family building. OC was initially used for...

    Authors: Zachary Walker, Andrea Lanes and Elizabeth Ginsburg
    Citation: Reproductive Biology and Endocrinology 2022 20:10
    Content type: Review Published on:

  36. Intrauterine adhesion (IUA) is one of the leading causes of infertility and the main clinical challenge is the high recurrence rate. The key to solving this dilemma lies in elucidating the mechanisms of endome...

    Authors: Chengcheng Xu, Meng Bao, Xiaorong Fan, Jin Huang, Changhong Zhu and Wei Xia
    Citation: Reproductive Biology and Endocrinology 2022 20:9
    Content type: Research Published on:

    The Correction to this article has been published in Reproductive Biology and Endocrinology 2022 20:31

  37. Preeclampsia is characterized by decreased trophoblastic angiogenesis leading to abnormal invasion of spiral arteries, shallow implantation and resulting in compromised placentation with poor uteroplacental pe...

    Authors: David B. Seifer, Geralyn Lambert-Messerlian, Glenn E. Palomaki, Robert M. Silver, Corette Parker, Carol J. Rowland Hogue, Barbara J. Stoll, George R. Saade, Robert L. Goldenberg, Donald J. Dudley, Radek Bukowski, Halit Pinar and Uma M. Reddy
    Citation: Reproductive Biology and Endocrinology 2022 20:8
    Content type: Research Published on:

  38. The primary objective of the present study of women participating in an ICSI program was to determine whether the morphologic quality of oocytes was related to the polycystic ovary syndrome (PCOS) phenotype.

    Authors: Audrey Uk, Christine Decanter, Camille Grysole, Laura Keller, Hélène Béhal, Mauro Silva, Didier Dewailly, Geoffroy Robin and Anne-Laure Barbotin
    Citation: Reproductive Biology and Endocrinology 2022 20:7
    Content type: Research Published on:

  39. Moving from the correlation between insulin-resistance and PCOS, metformin has been administered in some PCOS women improving ovulatory and metabolic functions and decreasing androgen levels. Inconsistency and...

    Authors: Emanuele Garzia, Valentina Galiano, Giovanni Marfia, Stefania Navone, Enzo Grossi and Anna Maria Marconi
    Citation: Reproductive Biology and Endocrinology 2022 20:6
    Content type: Research Published on:

  40. Potassium channels are important for the structure and function of the spermatozoa. As a potassium transporter, the mSlo3 is essential for male fertility as Slo3 knockout male mice were infertile with the series ...

    Authors: Mingrong Lv, Chunyu Liu, Chunjie Ma, Hui Yu, Zhongmei Shao, Yang Gao, Yiyuan Liu, Huan Wu, Dongdong Tang, Qing Tan, Junqiang Zhang, Kuokuo Li, Chuan Xu, Hao Geng, Jingjing Zhang, Hang Li…
    Citation: Reproductive Biology and Endocrinology 2022 20:5
    Content type: Research Published on:

  41. Insulin resistance (IR) contributes to ovarian dysfunctions in polycystic ovarian syndrome (PCOS) patients. Serum amyloid A1 (SAA1) is an acute phase protein produced primarily by the liver in response to infl...

    Authors: Qinling Zhu, Yue Yao, Lizhen Xu, Hasiximuke Wu, Wangsheng Wang, Yaqiong He, Yuan Wang, Yao Lu, Jia Qi, Ying Ding, Xinyu Li, Jiaan Huang, Hanting Zhao, Yanzhi Du, Kang Sun and Yun Sun
    Citation: Reproductive Biology and Endocrinology 2022 20:4
    Content type: Research Published on:

  42. Successful implantation is dependent on coordination between maternal endometrium and embryo, and the role of EVs in the required cross-talk cell-to-cell has been recently established. In this regard, it has b...

    Authors: Marina Segura-Benítez, María Cristina Carbajo-García, Ana Corachán, Amparo Faus, Antonio Pellicer and Hortensia Ferrero
    Citation: Reproductive Biology and Endocrinology 2022 20:3
    Content type: Research Published on:

  43. Women with uterine adenomyosis seeking assisted reproduction have been associated with compromised endometrial receptivity to embryo implantation. To understand the mechanisms involved in this process, we aime...

    Authors: Erika Prašnikar, Tanja Kunej, Mario Gorenjak, Uroš Potočnik, Borut Kovačič and Jure Knez
    Citation: Reproductive Biology and Endocrinology 2022 20:2
    Content type: Research Published on:

  45. Several clinical studies showed that statins were potential to treat polycystic ovary syndrome (PCOS). Through comprehensive search PubMed, EMBASE, the Web of Science, BIOSIS, the ClinialTrails.gov, and the Co...

    Authors: Jianguo Chen, Chaoran Huang, Tongtong Zhang, Wuqing Gong, Xiaofeng Deng, Hua Liu, Jinbo Liu and Yuanbiao Guo
    Citation: Reproductive Biology and Endocrinology 2021 19:189
    Content type: Research Published on:

    The Correction to this article has been published in Reproductive Biology and Endocrinology 2022 20:66

  46. To investigate the role of adenosine monophosphate (AMP)-activated protein kinase (AMPK) on the production of interleukin (IL)-8, monocyte chemoattractant protein (MCP)-1, prostaglandin E2 and F2α induced by I...

    Authors: Yasushi Kawano, Hatsumi Sato, Kaori Goto, Masakazu Nishida and Kaei Nasu
    Citation: Reproductive Biology and Endocrinology 2021 19:188
    Content type: Research Published on:

  47. Recurrent implantation failure (RIF) is a major limitation of assisted reproductive technology, which is associated with impaired endometrial receptivity. Although N6-methyladenosine (m6A) has been demonstrated t...

    Authors: Pingping Xue, Wenbo Zhou, Wenqiang Fan, Jianya Jiang, Chengcai Kong, Wei Zhou, Jianmei Zhou, Xiaoyang Huang, Haiyan Yang, Qian Han, Bin Zhang, Lingyun Xu, Bin Yu and Li Chen
    Citation: Reproductive Biology and Endocrinology 2021 19:187
    Content type: Research Published on:

  48. The goal of this study was to investigate which factors, excluding embryo aneuploidies, are associated with miscarriage in patients who have undergone a single euploid blastocyst transfer.

    Authors: María del Carmen Nogales, María Cruz, Silvia de Frutos, Eva María Martínez, María Gaytán, Marta Ariza, Fernando Bronet and Juan A. Garcia-Velasco
    Citation: Reproductive Biology and Endocrinology 2021 19:186
    Content type: Research Published on:

  49. For the association between time-lapse technology (TLT) and embryo ploidy status, there has not yet been fully understood. TLT has the characteristics of large amount of data and non-invasiveness. If we want t...

    Authors: Bo Huang, Wei Tan, Zhou Li and Lei Jin
    Citation: Reproductive Biology and Endocrinology 2021 19:185
    Content type: Research Published on:

  50. Polycystic ovary syndrome (PCOS) is a common endocrine disorder with the disorders of estrogen(E2) and progesterone(P) secretion. The purpose of this study was to evaluate the association between the progester...

    Authors: Yiqing Yang, Bowen Liu, Gengxiang Wu and Jing Yang
    Citation: Reproductive Biology and Endocrinology 2021 19:184
    Content type: Research Published on:
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Reproductive Biology and Endocrinology

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