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  1. Selective progesterone receptor modulators (SPRMs) represent a new class of progesterone receptor ligands that exert clinically relevant tissue-selective progesterone agonist, antagonist, partial, or mixed ago...

    Authors: Kristof Chwalisz, Ramesh Garg, Robert Brenner, Ov Slayden, Craig Winkel and Walter Elger

    Citation: Reproductive Biology and Endocrinology 2006 4(Suppl 1):S8

    Content type: Review

    Published on:

    This article is part of a Supplement: Volume 4 Supplement 1

  2. Endometriosis is one of the most common causes of chronic pelvic pain and infertility in women in the reproductive age group. Although the existence of this disease has been known for over 100 years our curren...

    Authors: Julie M Hastings and Asgerally T Fazleabas

    Citation: Reproductive Biology and Endocrinology 2006 4(Suppl 1):S7

    Content type: Review

    Published on:

    This article is part of a Supplement: Volume 4 Supplement 1

  3. This review focuses on the complex events that occur in the endometrium after progesterone is withdrawn (or blocked) and menstrual bleeding ensues. A detailed understanding of these local mechanisms will enhan...

    Authors: Hilary OD Critchley, Rodney W Kelly, David T Baird and Robert M Brenner

    Citation: Reproductive Biology and Endocrinology 2006 4(Suppl 1):S5

    Content type: Review

    Published on:

    This article is part of a Supplement: Volume 4 Supplement 1

  4. Endometrium is a dynamic tissue that responds on a cyclic basis to circulating levels of the ovarian-derived steroid hormones, estradiol and progesterone. Functional genomics has enabled a global approach to u...

    Authors: Linda C Giudice

    Citation: Reproductive Biology and Endocrinology 2006 4(Suppl 1):S4

    Content type: Review

    Published on:

    This article is part of a Supplement: Volume 4 Supplement 1

  5. This contribution will trace some of the many seminal studies on the female uterus (endometrium) over the centuries and conclude with a description of some current research initiatives in our laboratory. Numer...

    Authors: William C Okulicz

    Citation: Reproductive Biology and Endocrinology 2006 4(Suppl 1):S3

    Content type: Review

    Published on:

    This article is part of a Supplement: Volume 4 Supplement 1

  6. Fluid homeostasis is critical for normal function of the male reproductive tract and aquaporins (AQP) play an important role in maintenance of this water and ion balance. Several AQPs have been identified in t...

    Authors: Patrícia Picciarelli-Lima, André G Oliveira, Adelina M Reis, Evanguedes Kalapothakis, Germán AB Mahecha, Rex A Hess and Cleida A Oliveira

    Citation: Reproductive Biology and Endocrinology 2006 4:51

    Content type: Research

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  7. Ovarian follicular development is primarily dependent on pituitary gonadotropins. Identification of gonadotropin-inducible genes in the ovary is one of the effective approaches for the study of follicular deve...

    Authors: Miki Yoshino, Tetsuya Mizutani, Kazuya Yamada, Takashi Yazawa, Hiroko Ogata-Kawata, Toshio Sekiguchi, Takashi Kajitani and Kaoru Miyamoto

    Citation: Reproductive Biology and Endocrinology 2006 4:50

    Content type: Research

    Published on:

  8. Environmental estrogenic compounds which bind to the estrogen receptor (ER) can block or alter endogenous functions of estrogen in reproductive and developmental stages. A microarray technology is a very valua...

    Authors: Eui-Ju Hong, Se-Hyung Park, Kyung-Chul Choi, Peter CK Leung and Eui-Bae Jeung

    Citation: Reproductive Biology and Endocrinology 2006 4:49

    Content type: Research

    Published on:

  9. Mammalian sperm-oocyte interaction at fertilization involves several combined interactions between integrins on the oocyte and integrin ligands (disintegrins) on the sperm. Recent research has indicated the ab...

    Authors: Carla Tatone and Maria Cristina Carbone

    Citation: Reproductive Biology and Endocrinology 2006 4:48

    Content type: Research

    Published on:

  10. Estradiol (E2) and progesterone (P) are well known regulators of progesterone receptor (PR) expression in the rat uterus. However, it is not known which receptor subtypes are involved. Little knowledge exist a...

    Authors: Lena Sahlin, Britt Masironi, Sonja Åkerberg and Håkan Eriksson

    Citation: Reproductive Biology and Endocrinology 2006 4:47

    Content type: Research

    Published on:

  11. In mammals it is well known that infections can lead to alterations in reproductive function. As part of the innate immune response, a number of cytokines and other immune factors is produced during bacterial ...

    Authors: Simon MacKenzie, Nuria Montserrat, Mario Mas, Laura Acerete, Lluis Tort, Aleksei Krasnov, Frederick W Goetz and Josep V Planas

    Citation: Reproductive Biology and Endocrinology 2006 4:46

    Content type: Research

    Published on:

  12. The uterus is exposed to changes such as enlargement and distension during pregnancy and labor. In these processes and in the process of cervical ripening, proprioceptive information is likely to be of great i...

    Authors: Berith K Tingaker, Gunvor Ekman-Ordeberg and Sture Forsgren

    Citation: Reproductive Biology and Endocrinology 2006 4:45

    Content type: Research

    Published on:

  13. There is evidence that one gonad has functional predominance. The present study analyzed the acute effects of unilateral ovariectomy (ULO) and blocking the cholinergic system, by injecting atropine sulfate (AT...

    Authors: María E Cruz, Angélica Flores, María T Palafox, Griselda Meléndez, Jorge O Rodríguez, Roberto Chavira and Roberto Domínguez

    Citation: Reproductive Biology and Endocrinology 2006 4:43

    Content type: Research

    Published on:

  14. The existing dogma that the former term ovarian "germinal epithelium" resulted from a mistaken belief that it could give rise to new germ cells is now strongly challenged.

    Authors: Takashi Nishida and Naoyo Nishida

    Citation: Reproductive Biology and Endocrinology 2006 4:42

    Content type: Debate

    Published on:

  15. The coexistence of endometrial and immune cells during decidualization is preserved by the ability of endometrial cells to regulate the cytotoxic immune activity and their capability to be resistant to immune-...

    Authors: Lukasz Wicherek, Magdalena Dutsch-Wicherek, Krystyna Galazka, Tomasz Banas, Tadeusz Popiela, Agata Lazar and Beata Kleinrok-Podsiadlo

    Citation: Reproductive Biology and Endocrinology 2006 4:41

    Content type: Research

    Published on:

  16. The Deleted-in-AZoospermia-Like (DAZL) gene has homologs required for germ cell development in many organisms. Recently, we showed that there are several common polymorphisms within the DAZL gene that are associa...

    Authors: Joyce Y Tung, Mitchell P Rosen, Lawrence M Nelson, Paul J Turek, John S Witte, Daniel W Cramer, Marcelle I Cedars and Renee A Reijo-Pera

    Citation: Reproductive Biology and Endocrinology 2006 4:40

    Content type: Research

    Published on:

  17. The hormonal control of oocyte maturation and ovulation as well as the molecular mechanisms of nuclear maturation have been thoroughly studied in fish. In contrast, the other molecular events occurring in the ...

    Authors: Julien Bobe, Jerôme Montfort, Thaovi Nguyen and Alexis Fostier

    Citation: Reproductive Biology and Endocrinology 2006 4:39

    Content type: Research

    Published on:

  18. Both recombinant FSH (r-FSH) and highly-purified, urinary FSH (HP-uFSH) are frequently used in ovulation induction associated with timed sexual intercourse. Their effectiveness is reported to be similar, and t...

    Authors: Alberto Revelli, Francesca Poso, Gianluca Gennarelli, Federica Moffa, Giuseppina Grassi and Marco Massobrio

    Citation: Reproductive Biology and Endocrinology 2006 4:38

    Content type: Research

    Published on:

  19. It has been previously shown that cultured granulosa cells (GCs) derived from human ovarian preovulatory follicles contain choline acetyltransferase (ChAT), the enzyme responsible for acetylcholine (ACh) synth...

    Authors: Artur Mayerhofer, Lars Kunz, Annette Krieger, Becky Proskocil, Eliot Spindel, Abraham Amsterdam, Gregory A Dissen, Sergio R Ojeda and Ignaz Wessler

    Citation: Reproductive Biology and Endocrinology 2006 4:37

    Content type: Research

    Published on:

  20. A key role of estrogens in human sperm biology has been recently suggested by aromatase and estrogen receptor detection in human testicular germ cells and ejaculated spermatozoa. However, the involvement of th...

    Authors: Vittoria Rago, Laura Siciliano, Saveria Aquila and Amalia Carpino

    Citation: Reproductive Biology and Endocrinology 2006 4:36

    Content type: Research

    Published on:

  21. FSH, which binds to specific receptors on granulosa cells in mammals, plays a key role in folliculogenesis. Its biological activity involves stimulation of intercellular communication and upregulation of stero...

    Authors: A Bonnet, PO Frappart, P Dehais, G Tosser-Klopp and F Hatey

    Citation: Reproductive Biology and Endocrinology 2006 4:35

    Content type: Research

    Published on:

  22. The endangered Wyoming toad (Bufo baxteri) is the subject of an extensive captive breeding and reintroduction program. Wyoming toads in captivity rarely ovulate spontaneously and hormonal induction is used to ...

    Authors: Robert K Browne, Jessica Seratt, Carrie Vance and Andrew Kouba

    Citation: Reproductive Biology and Endocrinology 2006 4:34

    Content type: Research

    Published on:

  23. The follicle-stimulating hormone receptor (FSH-R) is a seven transmembrane spanning receptor (7TMR) which plays a crucial role in male and female reproduction. Upon FSH stimulation, the FSH-R activates the ext...

    Authors: Vincent Piketty, Elodie Kara, Florian Guillou, Eric Reiter and Pascale Crepieux

    Citation: Reproductive Biology and Endocrinology 2006 4:33

    Content type: Research

    Published on:

  24. The changes occurring in the rodent uterus after parturition can be used as a model of extensive tissue remodeling. As the uterus returns to its prepregnancy state, the involuting uterus undergoes a rapid redu...

    Authors: Kengo Manase, Toshiaki Endo, Mitunobu Chida, Kunihiko Nagasawa, Hiroyuki Honnma, Kiyohiro Yamazaki, Yoshimitu Kitajima, Taeko Goto, Mika Kanaya, Takuhiro Hayashi, Toshihiro Mitaka and Tsuyoshi Saito

    Citation: Reproductive Biology and Endocrinology 2006 4:32

    Content type: Research

    Published on:

  25. Hystricognath rodents have a lobed placenta, comprising labyrinthine exchange areas and interlobular trophoblast. These correspond to the labyrinthine and spongy zones of other rodent placentae. Beneath them, ...

    Authors: Rosangela Felipe Rodrigues, Anthony M Carter, Carlos Eduardo Ambrosio, Tatiana Carlesso dos Santos and Maria Angelica Miglino

    Citation: Reproductive Biology and Endocrinology 2006 4:31

    Content type: Research

    Published on:

  26. Some pesticides may interfere with the female hormonal function, which may lead to negative effects on the reproductive system through disruption of the hormonal balance necessary for proper functioning. Previ...

    Authors: Reini W Bretveld, Chris MG Thomas, Paul TJ Scheepers, Gerhard A Zielhuis and Nel Roeleveld

    Citation: Reproductive Biology and Endocrinology 2006 4:30

    Content type: Review

    Published on:

  27. Preterm birth is still the leading cause of neonatal morbidity and mortality. The level of corticotropin-releasing hormone (CRH) is known to be significantly elevated in the maternal plasma at preterm birth. A...

    Authors: Aurelija Klimaviciute, Jacopo Calciolari, Emma Bertucci, Susanne Abelin-Tornblöm, Ylva Stjernholm-Vladic, Birgitta Byström, Felice Petraglia and Gunvor Ekman-Ordeberg

    Citation: Reproductive Biology and Endocrinology 2006 4:29

    Content type: Research

    Published on:

  28. The prostate is a key gland in the sexual physiology of male mammals. Its sensitivity to steroid hormones is widely known, but its response to prolactin is still poorly known. Previous studies have shown a cor...

    Authors: Maria Elena Hernandez, Abraham Soto-Cid, Fausto Rojas, Luz I Pascual, Gonzalo E Aranda-Abreu, Rebeca Toledo, Luis I Garcia, Andres Quintanar-Stephano and Jorge Manzo

    Citation: Reproductive Biology and Endocrinology 2006 4:28

    Content type: Research

    Published on:

  29. Exposure to dioxins results in a broad range of pathophysiological disorders in human fetuses. In order to evaluate the effects of dioxins on the feto-placental tissues, we analyzed the gene expression in 2,3,...

    Authors: Yumiko Abe, Hiromitsu Sinozaki, Takeshi Takagi, Takashi Minegishi, Koichi Kokame, Kenji Kangawa, Miki Uesaka and Kaoru Miyamoto

    Citation: Reproductive Biology and Endocrinology 2006 4:27

    Content type: Research

    Published on:

  30. During maturation, the last phase of oogenesis, the oocyte undergoes several changes which prepare it to be ovulated and fertilized. Immature oocytes are arrested in the first meiotic process prophase, that is...

    Authors: Elisabetta Tosti

    Citation: Reproductive Biology and Endocrinology 2006 4:26

    Content type: Review

    Published on:

  31. In human, respiratory distress of the neonates, which occurs in prematurity, is prevalent in male. Late in gestation, maturation of type II pneumonocytes, and consequently the surge of surfactant synthesis are...

    Authors: Marc Simard, Pierre R Provost and Yves Tremblay

    Citation: Reproductive Biology and Endocrinology 2006 4:25

    Content type: Research

    Published on:

  32. Prolonged labour is associated with greater morbidity and mortality for mother and child. Connexin 43 is a major myometrial gap junction protein found in human myometrium. Syndecan 3 seems to prevail in the hu...

    Authors: Ann Hjelm Cluff, Birgitta Byström, Aurelija Klimaviciute, Camilla Dahlqvist, Gvido Cebers, Anders Malmström and Gunvor Ekman-Ordeberg

    Citation: Reproductive Biology and Endocrinology 2006 4:24

    Content type: Research

    Published on:

  33. Sperm binding proteins and their C-terminal peptides of the Sperm Associated Antigen 11 (SPAG11) family were found to play an important role in epididymal innate immunity in addition to their role in sperm mat...

    Authors: Suresh Yenugu, Katherine G Hamil, Gail Grossman, Peter Petrusz, Frank S French and Susan H Hall

    Citation: Reproductive Biology and Endocrinology 2006 4:23

    Content type: Research

    Published on:

  34. The ability of ovarian follicles to produce large amounts of estradiol is a hallmark of follicle health status. Estradiol producing capacity is lost in ovarian follicles before morphological signs of atresia. ...

    Authors: Yasuhiro Kobayashi, Fermin Jimenez-Krassel, James J Ireland and George W Smith

    Citation: Reproductive Biology and Endocrinology 2006 4:22

    Content type: Review

    Published on:

  35. It has now been a decade since the first discovery of the intracellular Smad proteins, the downstream signalling molecules of one of the most important growth factor families in the animal kingdom, the transfo...

    Authors: Noora Kaivo-oja, Luke A Jeffery, Olli Ritvos and David G Mottershead

    Citation: Reproductive Biology and Endocrinology 2006 4:21

    Content type: Review

    Published on:

  36. Ovarian folliculogenesis in mammals from the constitution of primordial follicles up to ovulation is a reasonably well understood mechanism. Nevertheless, underlying mechanisms that determine the number of ovu...

    Authors: Stéphane Fabre, Alice Pierre, Philippe Mulsant, Loys Bodin, Elisa Di Pasquale, Luca Persani, Philippe Monget and Danielle Monniaux

    Citation: Reproductive Biology and Endocrinology 2006 4:20

    Content type: Review

    Published on:

  37. Ovarian folliculogenesis is regulated by both endocrine and intraovarian mechanisms that coordinate the processes of oocyte growth and somatic cell proliferation and differentiation. Within the follicle, parac...

    Authors: Fiona H Thomas and Barbara C Vanderhyden

    Citation: Reproductive Biology and Endocrinology 2006 4:19

    Content type: Review

    Published on:

  38. Angiogenesis is associated with follicular development and is regulated independently within each follicle potentially making the functioning of its vasculature critically important in determining its fate. Th...

    Authors: Hamish M Fraser

    Citation: Reproductive Biology and Endocrinology 2006 4:18

    Content type: Review

    Published on:

  39. The steroidogenic pathway within the ovary gives rise to progestins, androgens and oestrogens, all of which act via specific nuclear receptors to regulate reproductive function and maintain fertility. The role...

    Authors: Ann E Drummond

    Citation: Reproductive Biology and Endocrinology 2006 4:16

    Content type: Review

    Published on:

  40. Zygote arrest 1 (ZAR1) is one of the few known oocyte-specific maternal-effect genes essential for the beginning of embryo development discovered in mice. This gene is evolutionary conserved in vertebrates and...

    Authors: Svetlana Uzbekova, Monica Roy-Sabau, Rozenn Dalbiès-Tran, Christine Perreau, Pascal Papillier, Florence Mompart, Aurore Thelie, Sophie Pennetier, Juliette Cognie, Veronique Cadoret, Dominique Royere, Philippe Monget and Pascal Mermillod

    Citation: Reproductive Biology and Endocrinology 2006 4:12

    Content type: Research

    Published on:

  41. The presence of asymmetry in the capacity of the left and right ovaries to secrete testosterone was analyzed by studying the effects of hemiovariectomy along the estrus cycle one hour after surgery. The effect...

    Authors: Angélica Flores, Jorge O Rodríguez, María T Palafox, Griselda Meléndez, Ana I Barco, Roberto Chavira, M Esther Cruz and Roberto Domínguez

    Citation: Reproductive Biology and Endocrinology 2006 4:11

    Content type: Research

    Published on:

  42. Inorganic arsenic is a major water pollutant and a known human carcinogen that has a suppressive influence on spermatogenesis and androgenesis in male reproductive system. However, the actual molecular events ...

    Authors: Kuladip Jana, Subarna Jana and Prabhat Kumar Samanta

    Citation: Reproductive Biology and Endocrinology 2006 4:9

    Content type: Research

    Published on:

  43. Three transcription factors that are expressed at high levels in embryonic stem cells (ESCs) are Nanog, Oct-4 and Sox-2. These transcription factors regulate the expression of other genes during development an...

    Authors: Ryan Carlin, Duane Davis, Mark Weiss, Bruce Schultz and Deryl Troyer

    Citation: Reproductive Biology and Endocrinology 2006 4:8

    Content type: Research

    Published on:

  44. beta-defensins are small cationic peptides that exhibit broad spectrum antimicrobial properties. The majority of beta-defensins identified in humans are predominantly expressed in the male reproductive tract a...

    Authors: Suresh Yenugu, Vishnu Chintalgattu, Christopher J Wingard, Yashwanth Radhakrishnan, Frank S French and Susan H Hall

    Citation: Reproductive Biology and Endocrinology 2006 4:7

    Content type: Research

    Published on:

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