Skip to main content
Fig. 1 | Reproductive Biology and Endocrinology

Fig. 1

From: Estrogen-sensitive activation of SGK1 induces M2 macrophages with anti-inflammatory properties and a Th2 response at the maternal–fetal interface

Fig. 1

Serum E2 declines as gestational age increases in early miscarriage and SGK1 is downregulated in decidual macrophages of RPL. A The concentrations of serum E2 (pg/ml) during the 4th–12th week of gestation in a study population with live birth (n = 448) or miscarriage (n = 68) in the first trimester. B The variation of serum E2 (pg/ml) with weeks during early pregnancy in women with a viable fetus or miscarriage. C Decidual tissue sections obtained from first trimester of gestation were double stained with anti-human SGK1 antibody (red) and anti-human CD68 antibody (green) using laser scanning confocal microscopy; nuclear DNA was stained with DAPI (blue). The yellow-orange color in the merged images indicates the colocalization of SGK1 and CD68+ macrophages in decidual tissue, n = 3, at 630 × magnification, scale bar 25 μm. D The ordinate represents the quantification of immunoreactive SGK1 levels/decidual area (μm2) acquired in (C). E The ordinate indicates the quantification of immunoreactive SGK1 staining in decidual CD68+ macrophages obtained from 1C. **P < 0.01, ***P < 0.001, contrasted to normal pregnancy group. E2, estradiol; SGK1, serum-glucocorticoid regulated kinase; RPL, recurrent pregnancy loss; CD68, CD68 molecule; DAPI, 4’,6-diamidino-2-phenylindole

Back to article page