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Table 2 Clinical outcomes

From: Granulocyte colony-stimulating factor priming improves embryos and pregnancy rate in patients with poor ovarian reserve: a randomized controlled trial

Strategy or outcome

G-CSF group

Control group

Patients completing the study

50 patients

49 patients

Conventional infertility treatments in initial and second cycles with or without G-CSF priming

 Live deliveries (% per patient)

3 a (6.0%)

0 (0%)

IVF/ICSI and fresh ET

 Ovarian stimulation (OS)

47 patients

49 patients

 No follicular development induced (% per OS)

0 (0%)

1 (2.0%)

 Numbers of follicles (≥ 16 mm) on the hCG day

4.2 ± 2.9

3.0 ± 1.7

 Serum E2 concentrations (pg/mL) on the hCG day

1820 ± 1200

1350 ± 840

 Successful oocyte retrievals (% per OS)

47 (100%)

48 (98%)

 No ET for lack of transferrable embryos (% per OS)

2 (4.3%)

4 (8.2%)

 Fresh ETs (% per OS)

45 (96%)

44 (90%)

 Cryopreservation of redundant blastocysts possible (% per OS)

25 (53%) b

12 (24%)

 Clinical pregnancies (% per OS)

14 (30%) c

6 (12%)

 Ongoing pregnancies (% per OS)

12 (26%) d

5 (10%)

 Live deliveries (% per OS)

9 (19%)

5 (10%)

Cryopreserved ET

21 cycles

14 cycles

 Clinical pregnancies (% per cryopreserved ET)

6 (29%)

4 (29%)

 Live deliveries (% per cryopreserved ET)

4 (19%)

2 (14%)

Numbers of cumulative live deliveries (% per patient)

16 (32%) e

7 (14%)

  1. a All 3 patients conceived with spontaneous ovulation following initial G-CSF priming
  2. bP < 0.01 vs. control group, chi-squared test; relative risk (RR) = 3.5; 95% confidence interval (CI), 1.5–8.3
  3. cP < 0.05 vs. control group, chi-squared test; RR = 3.0; 95% CI, 1.1–8.8
  4. dP < 0.05 vs. control group, chi-squared test; RR = 3.0; 95% CI, 1.0–9.4
  5. eP < 0.05 vs. control group, chi-squared test; RR = 2.8; 95% CI, 1.04–7.7