Fig. 5

Chromosome 8p12-p11.22 gene map and the topological structure of FGFR1. A The orange box in the chromosome 8 diagram at the top indicated the region highlighted below. The OMIM morbid genes are listed at the bottom. B Membrane topology structure of full length FGFR1. Each circle represented a residue with the one-letter symbol. The different domains were labeled as indicated. Locations of pathogenic variations were colored as indicated. and the red box marked the amino acids that affected by FRFR1 c.1835delA mutation