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Table 1 Clinical characteristics of participants

From: The effect of growth hormone on the metabolome of follicular fluid in patients with diminished ovarian reserve

 

Control group (n = 32)

GH group (n = 32)

P-value

Age (years)

34 (31, 38)

33 (32, 37)

0.96a

BMI (kg/m2)

20.9 (19.5, 23.3)

20.7 (19.9, 21.8)

0.37a

Duration of infertility (years)

2 (1.0, 5.3)

4.5 (2.0, 7.3)

0.17a

Previous conception

62.5% (20/32)

40.6% (13/32)

0.13b

Previous IVF attempt

0 (0, 1)

1 (0, 1)

0.16a

AMH (ng/mL)

1.1 (0.9, 1.4)

1.2 (0.9, 1.8)

0.32a

AFC

3.5 (2.8, 5.0)

4.0 (3.0, 5.0)

0.39a

Basal FSH (IU/L)

9.2 ± 2.7

9.4 ± 2.7

0.80c

Basal LH (IU/L)

4.9 (3.7, 5.7)

5.4 (4.2, 5.7)

0.36a

Basal E2 (pg/mL)

38.8 (30.7, 63.2)

43.2 (29.8, 59.5)

0.65a

Days of stimulation

7 (6.0, 7.3)

7 (5.8, 8.0)

0.96a

FSH dose (IU)

637.5 (450.0, 1050.0)

675.0 (450.0, 1050.0)

0.64a

LH dose (IU)

450 (150.0, 618.8)

450 (300.0, 618.8)

0.83a

E2 on the day of hCG (pg/mL)

1160.3 ± 582.6

1380.8 ± 638.2

0.15c

Follicles ≥14 mm on day of hCG

2 (1, 3)

3 (2, 4)

0.03a

No. of oocytes retrieved

2 (1, 3)

3 (2, 4)

0.04a

Normal fertilization rate

69.1% (47/68)

82.4% (75/91)

0.05b

No. of Day 3 available embryo

0 (0, 1)

0 (0, 2)

0.56a

  1. Normal fertilization rate: the percentage of 2PN zygotes to oocytes retrieved
  2. Day 3 available embryo: an embryo with ≥5 blastomeres and ≤ 30% fragmentation in 68 ± 1 h after insemination
  3. Abbreviations: BMI Body mass index, IVF In vitro fertilization, AMH Anti-Müllerian hormone, AFC Antral follicle count, FSH Follicle stimulating hormone, LH Luteinizing hormone, E2 Estradiol, hCG Human chorionic gonadotropin, No. Number
  4. aMann–Whitney U test. The data were expressed as the median (25th percentile, 75th percentile)
  5. bPearson’s chi-squared test. The data were expressed as percentage (numerator/denominator)
  6. cStudent t-test. The data were expressed as the mean ± SD