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Table 4 Baseline clinical characteristics, nirsERT results and clinical outcomes of 22 patients undergoing IVF

From: Can biomarkers identified from the uterine fluid transcriptome be used to establish a noninvasive endometrial receptivity prediction tool? A proof-of-concept study

 

Normal

WOI

Displaced

WOI

P-value

Detection failed

Total

Date of transfer

LH + 7/P + 5

LH + 7/P + 5

 

LH + 7/P + 5

/

Predicted result

Receptivity

Pre-receptivity

 

/

/

No. of patients

18

3

 

1

22

Age, Mean ± SD, y

30.4 ± 3.87

28.67 ± 3.51

0.466

33

/

BMI, Mean ± SD, kg/m2

20.95 ± 2.49

22.53 ± 0.76

0.297

21.6

/

Infertility duration, Median (IQR), y

2(1–5)

2a

0.387

5

/

AMH, Median (IQR), ng/ml

2.90(2.36–5.29)

6.32a

0.430

3.10

/

FSH, Mean ± SD, mIU/ml

5.74 ± 0.88

5.70 ± 1.33

0.952

4.67

/

Endometrial thickness, Mean ± SD, mm

11.21 ± 2.03

9.33 ± 2.14

0.158

11.80

/

P levels on the day of progesterone administration/LH peak, Median (IQR), ng/ml

0.90 (0.06–0.20)

0.57a

0.164

0.61

/

IVF indication

 Tubal factor (n/%)

14 (77.8%)

1 (33.3%)

0.242

1

/

 PCOS (n/%)

3 (16.7%)

2 (66.7%)

 

/

/

 Ovulation disorder (n/%)

2(11.1%)

1 (33.3%)

 

/

/

 Male factor (n/%)

1(5.6%)

0

 

/

/

 Diminished ovarian reserve (n/%)

1(5.6%)

0

 

/

/

Cycle protocol

 Natural cycle (n/%)

7(38.9%)

1(33.3%)

0.101

/

8

 HRT cycle (n/%)

11(61.1%)

2(66.7%)

 

1

14

No. of intrauterine pregnancy

14

0

 

0

14

 Intrauterine pregnancy rate

77.8%(14/18)

0

0.026

0

63.6%(14/22)

 Live birth rate

72.2%(13/18)

0

0.042

0

59.1%(13/22)

  1. Abbreviations: nirsERT non-invasive RNA-seq-based endometrial receptivity test, BMI body mass index, AMH antimullerian hormone, FSH follicle-stimulating hormone, PCOS polycystic ovarian syndrome
  2. aOnly the Median is listed because there are only three samples