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Fig. 2 | Reproductive Biology and Endocrinology

Fig. 2

From: H3K4me3 mediates uterine leiomyoma pathogenesis via neuronal processes, synapsis components, proliferation, and Wnt/β-catenin and TGF-β pathways

Fig. 2

Selection of differentially expressed genes and description of their H3K4me3 status in ULs compared to MM tissue. A Venn diagram representing common DEGs (FDR-adjusted p-value< 0.01, log2FC > 1 or < − 1) between GSE192354 (n = 28) and GSE142332 (n = 19) datasets. B Principal component analysis of global H3K4me3 profile. C Heatmap based on the fold-enrichment score of selected DEGs shared between GSE192354 and GSE142332, whose promoter region presented a peak after unsupervised clustering of CHIP-seq data from uterine leiomyomas (ULs; violet) and their adjacent myometrium (MM; gray) (n = 19/group). The color scale ranges from red, for a higher normalized fold-enrichment score, to blue, for lower levels. D Boxplot analysis of the distribution of normalized fold-enrichment score for each peak of downregulated and upregulated genes in ULs (violet) compared to their adjacent MM (gray) samples (n = 19/group), representing the H3K4me3 status in each group of genes

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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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