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Fig. 1 | Reproductive Biology and Endocrinology

Fig. 1

From: H3K4me3 mediates uterine leiomyoma pathogenesis via neuronal processes, synapsis components, proliferation, and Wnt/β-catenin and TGF-β pathways

Fig. 1

Overall H3K4me3 profile in uterine leiomyoma compared to adjacent myometrium tissues. Based on data extracted from GSE142332. A Principal component analysis of global H3K4me3 status in uterine leiomyomas (ULs; violet) and adjacent myometrium (MM; gray) (n = 19/group). B Heatmap representing the fold-enrichment score of genes with a CHIP-seq H3K4me3 peak in the promotor region after unsupervised clustering of ULs (violet) and MM (gray) (n = 19/group). The color scale ranges from red, for a higher normalized fold-enrichment score, to blue, for lower levels. C Boxplot analysis of the distribution of normalized fold-enrichment score for each peak in ULs (violet) compared to the adjacent MM (gray) samples (n = 19/group), representing the H3K4me3 profile

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