Table 3 Summary of studies comparing myoinositol treatment to metformin
Outcomes | Inositol vs Metformin | ||
|---|---|---|---|
N0 of studies (N0 of pts) | RR/ MD (95% CI) | GRADE | |
Total testosterone (ng/dl) | 4 (320) | 0.2 (-5.72; 6.12) | moderate |
Free testosterone(ng/dl) | - | - | - |
SHBG (nmol/L) | 3 (220) | 2.78 (0.02; 5.54) | moderate |
Androstenedione (ng/ml) | - | - | - |
DHEAS (µg/dl) | 1 (60) | 17.31 (-17.84; 52.46) | low |
Ferriman-Gallwey score | 3 (220) | 0.6 (0.24; 0.96) | high |
Glucose (mg/dl) | 5 (373) | -0.84 (-3.62; 1.93) | low |
Insulin (µU/ml) | 6 (427) | -0.37 (-1.52; 0.78) | high |
HOMA index | 6 (419) | -0.18( -0.41; 0.06) | high |
AUC Glucose (mg/dl/min) | 1 (60) | 1218.76 (-812.79; 3250.3) | moderate |
AUC insulin (µU/ml/min) | 1 (60) | 1593.71 (-2802.06; 5989.5) | moderate |
BMI (kg/m2) | 9 (593) | -0,11 (-0.25; 0.04) | high |
cycle normalisation | 6 (424) | 1.42 (0.8; 2.53) | very low |
pregnancy rate | 5 (383) | 1.22 (0.84; 1.78) | very low |
pregnancy rate (no other treatment) | 3 (183) | 1.38 (0.88; 2.15) | very low |