Table 2 Summary of studies comparing inositol stereoisomers to placebo
Outcomes | Inositol vs Placebo | Myo-Inositol vs Placebo | DCI vs Placebo | Inositol combination vs Placebo | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
N0 of studies (N0 of pts) | RR/ MD (95% CI) | GRADE | N0 of studies (N0 of pts) | RR/ MD (95% CI) | GRADE | N0 of studies (N0 of pts) | RR/ MD (95% CI) | GRADE | N0 of studies (N0 of pts) | RR/ MD (95% CI) | GRADE | |
Total testosterone (ng/dl) | 6 (284) | -20.39 (-40.12; -0.66) | moderate | 4 (220) | -11.38 (-29.48; 6.72) | moderate | 2 (64) | -41,71 (-70.09; -13.34) | high | - | - | - |
Free testosterone (ng/dl) | 4 (152) | -0.41 (-0.69; -0.13) | moderate | 1 (42) | -0.57 (-1; -0.14) | high | 2 (64) | -0.58 (-0.89; -0.28) | high | 1 (46) | -0,12 (-0.28; 0.04) | low |
SHBG (nmol/L) | 4(152) | 32.06 (1.27; 62.85) | moderate | 1 (42) | 37.6 (-43.97; 119.17) | moderate | 2(64) | 55.45 (25.99; 84.91) | high | 1 (46) | 10.82 (-1.7; 23.34) | moderate |
Androstenedione (ng/ml) | 6 (198) | -0.69 (-1.16; -0.22) | moderate | 3 (88) | -0.89 (-1.56; -0.22) | very low | 2 (64) | -0.52 (-1.13; -0.09) | low | 1 (46) | 0.12 (-1.3; 1.54) | low |
DHEAS (µg/dl) | 4 (152) | -92.54 (-206.31; 21.22) | low | 1 (42) | -114 (-294.53; 66.53) | high | 2 (64) | -168,48 (-281.15; -55.82) | moderate | 1 (46) | 42.4 (-89.68; 174.48) | low |
Ferriman-Gallwey score | 1(43) | -1.23 (-5.37; 2.92) | low | - | - | - | - | - | - | 1 (43)a | -1.23 (-5.37; 2.92a | lowa |
Glucose (mg/dl) | 5 (266) | -3.14 (-5.75; -0.54) | moderate | 3 (200) | -4.03(-6.59; -1.47) | moderate | 1 (20) | -9 (-28.26; 10.26) | low | 1 (46) | 2.47 (-3.96; 8.9) | low |
Insulin (µU/ml) | 6 (286) | -2.78 (-7.13; 1.57) | low | 4 (220) | 0.46 (-0.68; 1.59) | low | 1 (20) | -13 (-41,03; 15.03) | low | 1 (46) | -9.25 (-15.57; -2.93) | high |
HOMA index | 3 (92) | -0.23 (-1.19; 0.72) | low | 2 (46) | -0.17 (-1.57; 1.23) | moderate | - | - | - | 1 (46) | -0.73 (-2.2; 0.74) | low |
AUC Glucose (mg/dl/min) | 4 (132) | -763.3 (-1925.05; 398.45) | moderate | 2 (68) | -550.98 (-2182.91; 1080.95) | low | 2 (64) | -1502.41 (-3406.31; 401.48) | low | - | - | - |
AUC insulin (µU/ml/min) | 4 (132) | -2081.05 (-2745.32; -1,416.78) | high | 2 (68) | -2034.05 (-2706.3; -1361.81) | high | 2 (64) | -4027.17 (-8352.7; 298.33) | moderate | - | - | - |
BMI (kg/m2) | 8 (419) | -0.45 (-0.89; -0.02) | high | 5 (312) | -0.71 (-1.00; -0.43) | high | 2 (64) | 0.35 (-0.56; 1.27) | low | 1 (43)a | -0.21( -4.44; 4.01)a | lowa |
cycle normalization | 2 (118) | 1.79 (1.13; 2.85) | very low | 1(85) | 1.76 (1.06; 2.92) | moderate | - | - | - | 1 (33)a | 1.96 (0.63; 6.1)a | lowa |
pregnancy rate | 4 (308) | 1.24 (0.85; 1.81) | very low | 3 (159) | 0.92 (0.53; 1.61) | very low | - | - | - | 1 (149) | 1.45 (1.06; 1.98) | low |
pregnancy rate (no other treatment) | 1 (42) | 3.3 (0.4; 27.13) | low | 1 (42) | 3.3 (0.4; 27.13) | very low | - | - | - | - | – | - |