Table 2 Studies using mouse model of endometriosis to examine the effect of Vit D supplementation

Mariani et al., 2012 [36]

Italy

mouse model, endometriosis induced (allotransplantated endometrium) with injection

Controlled Trial

70

70

Elocalcitol (p.o.)

Elocalcitol led to

↓ lesion weight by 70%

↓ capacity of endometrial cells adherence to collagen inhibition of

macrophage and inflammatory cytokine secretion

Elocalcitol inhibits endometriosis lesions development

Abbas et al., 2013 [34]

Jordan

mouse model, surgically induced endometriosis of autotrasplanted endometrium; 2 surgeries

Controlled Trial

9

8

Vit D (i.p.)

Vit D led to

↓ lesion by 48.8%

↑ fibrosis and apoptosis in stroma

Vit D reduces endometriosis lesions

Yildirim et al., 2014 [35]

Turkey

mouse model, surgically induced endometriosis of autotransplanted endometrium

Controlled Trial

7 simultaneous group

7 sequential group

7

1,25(OH)2D3 (i.m.)

1,25(OH)2D3 led to

↓ lesion volume, weight

↓ VEGF, MMP-9 levels

↑ TIMP-2

1,25(OH)2D3 regresses endometriotic implants in rat models by altering implant levels of VEGF, TIMP-2, and MMP-9

Akyol et al., 2015 [33]

Turkey

mouse model, surgically induced endometriosis of autotransplanted uterine horn

Controlled Trial

8 (Vit. D)

9 (Omega-3)

9

Vit. D (i.p.)

Omega-3 (i.p.)

Vitamin D led to

↓ IL-6 levels

Omega-3 induced the regression of endometriosis implants in contrast to Vit D