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Table 1 Baseline clinical characteristics and laboratory variables in women with and without HDP

From: Higher daytime systolic BP, prepregnancy BMI and an elevated sFlt-1/PlGF ratio predict the development of hypertension in normotensive pregnant women

Variable

HDP (n = 14)

Non-HDP (n = 132)

p Value

Clinical characteristics

 Maternal age (y) *

33.6 ± 4.4

33.6 ± 4.3

0.9

 Family history AHT †

4 (28.6%)

58 (43.9%)

0.2

 Parity *

1.71 ± 1.4

1.89 ± 0.9

0.5

 Previous history of GDM †

1 (7.1%)

19 (14.4%)

0.4

 Previous history of preeclampsia †

1 (7.1%)

2 (1.5%)

0.1

 Gestational age at enrollement (w) *

31.2 ± 1.9

31.1 ± 1.9

0.8

 Pregestational BMI (kg/m2) *

30.1 ± 6.8

26.0 ± 5.0

0.046

 Obesity †

8 (57.1%)

28 (21.2%)

0.006

 GDM †

11 (78.6%)

67 (50.2%)

0.047

 Insulin treatment †

5 (45.4%)

24 (35.8%)

0.2

 Office Systolic BP (mmHg) *

118.5 ± 15.7

109.7 ± 15.4

0.043

 Office Diastolic BP (mmHg) *

74.5 ± 9.7

65.9 ± 9.0

0.001

 ASA prophylaxis †

5 (35.7%)

14 (10.6%)

0.008

Laboratory parameters

 Basal glucose (mmol/L) *

4.9 ± 0.5

4.8 ± 0.5

0.039

 HbA1c (%)*

5.2 ± 0.5

4.8 ± 0.3

0.002

 HOMA-IR *

2.9 ± 1.1

2.0 ± 1.3

0.09

 Albumin/creatinine (mg/g) *

28.3 ± 60.0

6.3 ± 6.6

0.1

 Uric acid (mmol/L) *

0.24 ± 0.06

0.22 ± 0.13

0.6

 Total-cholesterol (mmol/L) *

6.52 ± 0.86

6.45 ± 1.19

0.8

 LDL-cholesterol (mmol/L) *

3.76 ± 0.8

3.66 ± 1.22

0.7

 HDL-cholesterol (mmol/L) *

1.99 ± 0.42

1.92 ± 0.47

0.6

 Triglycerides (mmol/L) *

2.2 ± 0.6

2.1 ± 0.8

0.6

  1. * Data expressed as means ± standard deviation; comparisons between different groups were done by the Student’s t– test for parametric variables and the Mann–Whitney U– test for nonparametric variables
  2. † Data expressed as n (%); comparisons among groups were done using the χ2 test, or Fisher’s exact test for nonparametric contrasting
  3. HDP hypertensive disorders of pregnancy, AHT arterial hypertension, BMI body mass index, GDM gestational diabetes mellitus, BP blood pressure, ASA acetylsalicylic acid, HbA1c glycated hemoglobin, LDL low-density lipoprotein, HDL high-density lipoprotein