Fig. 6

Matrix metalloproteinases and their inhibitors in the implanted region of the uterus. Values are mean fold changes in gene expression, a. MMP-2, and b. MMP-9. c. Gelatin gel zymograms showing pro-MMP2, active MMP2, and active MMP9 activity (arrows) in the letrozole induced PCOS mice model (represented gel picture was cropped from the same gel- uncropped/original gel picture is given in supplementary fig. S3) d. Quantification of total (Pro and active) MMP9 and MMP2 by computer-based densitometry analysis. e. & f. Values are mean fold change in gene expression of tissue inhibitor of metalloproteinase TIMP-1 & TIMP-3 respectively. Error bars represent mean ± SEM; N = 6 per group. * P < 0.05, **P < 0.01, ***P < 0.001, ns-non-significant as compared to the control group