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Fig. 3 | Reproductive Biology and Endocrinology

Fig. 3

From: A promising future for endometriosis diagnosis and therapy: extracellular vesicles - a systematic review

Fig. 3

Proposed role of extracellular vesicles (EVs) in the development of endometriosis lesions. EVs derived from the endometrium act on endometrial cells shed during retrograde menstruation, allowing migration, implantation and immunomodulation. EVs from newly implanted ectopic endometrial cells enhance pathogenesis with ongoing immunomodulation and cell proliferation, as well as angiogenesis and fibrosis, leading to the formation of endometriosis lesions

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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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