Table 3 Patients’ characteristics association with the hsa-miR-320a-3p and the hsa-miR-483-5p levels in granulosa cells from human follicular fluids
Variable | Min-Max | Mean | n (%) | SD | hsa-miR-320a-3p | hsa-miR-483-5p | ||
|---|---|---|---|---|---|---|---|---|
β ± SE | P-value | β ± SE | P-value | |||||
Age (years) | 21-46 | 34.39 | 195 (100) | 5.19 | 4.79 × 105 ± 1.61 × 105 | 0.0033* | −3.58 ± 3.51 | 0.3084 |
BMI (kg/m2) | 8.93-32.40 | 22.53 | 194 (99.49) | 3.39 | 1.45 × 105 ± 2.54 × 105 | 0.5678 | −1.48 ± 5.43 | 0.7850 |
Female baseline levels | ||||||||
Basal FSH (IU/L) | 1.25-33.00 | 8.40 | 195 (100) | 3.86 | 7.90 × 105 ± 2.14 × 105 | 0.0003* | −3.42 ± 4.72 | 0.4701 |
Basal LH (IU/L) | 0.65-40.02 | 4.76 | 195 (100) | 3.77 | 7.61 × 103 ± 2.27 × 105 | 0.9733 | −0.97 ± 4.85 | 0.8412 |
Basal E2 (pg/ml) | 2.74-5178 | 76.17 | 195 (100) | 370.11 | −6.09 × 102 ± 2.3 × 103 | 0.7926 | −7.57 × 10−4 ± 4.94 × 10−2 | 0.9878 |
AMH (ng/ml) | 0.06-14.62 | 3.52 | 194 (99.49) | 2.93 | −1.91 × 105 ± 2.93 × 105 | 0.5147 | −3.917 × 10− 3 ± 6.039 × 10− 3 | 0.5174 |
Antral follicle count | 3-52 | 15.74 | 195 (100) | 7.97 | −5.39 × 104 ± 1.07 × 105 | 0.6159 | −0.13 ± 2.30 | 0.9535 |
Days of stimulation | 5-22 | 9.97 | 195 (100) | 2.48 | −6.85 × 105 ± 3.42 × 105 | 0.0466* | 0.31 ± 7.38 | 0.9660 |
Total dose of gonadotropins (IU) | 900-6450 | 2344.27 | 195 (100) | 842.52 | −1.39 × 103 ± 1.01 × 103 | 0.1704 | −7.40 × 10−3 ± 2.17 × 10−2 | 0.7333 |
Ovarian stimulation protocol | ||||||||
Ultra-long protocol | – | – | 62 (31.79) | – | Ref | |||
Long protocol | – | – | 9 (0.05) | – | −6.05 × 10−9 ± 5.36 × 10−9 | 0.263 | −2.57 × 10−5 ± 9.61 × 10− 5 | 0.790 |
Antagonist protocol | – | – | 75 (0.38) | – | −7.10 × 10−9 ± 6.15 × 10− 9 | 0.250 | −1.76 × 10−4 ± 1.42 × 10− 4 | 0.217 |
Progestin-primed ovarian stimulation (PPOS) | – | – | 40 (0.21) | – | 2.19 × 10− 9 ± 4.37 × 10− 9 | 0.617 | −1.30 × 10− 4 ± 1.40 × 10− 4 | 0.354 |
Mild stimulation protocol | – | – | 5 (0.03) | – | 8.27 × 10− 9 ± 2.92 × 10− 9 | 0.006* | −1.44 × 10− 5 ± 7.61 × 10− 5 | 0.851 |
Luteal phase stimulation | – | – | 4 (0.02) | – | 6.29 × 10− 9 ± 2.09 × 10− 9 | 0.004* | −1.93 × 10− 5 ± 6.91 × 10− 5 | 0.781 |